Search Results - "OUWEHAND, Mariët"

Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice by Bardelmeijer, Heleen A, Ouwehand, Mariët, Beijnen, Jos H, Schellens, Jan H M, van Tellingen, Olaf

“…P-glycoprotein inhibitors can increase the oral bioavailability of paclitaxel. We have now explored the mechanisms that determine the efficacy of several novel…”
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A simple and sensitive assay for the quantitative analysis of rivastigmine and its metabolite NAP 226-90 in human EDTA plasma using coupled liquid chromatography and tandem mass spectrometry by Frankfort, Suzanne V., Ouwehand, Mariët, van Maanen, Maria J., Rosing, Hilde, Tulner, Linda R., Beijnen, Jos H.

“…A sensitive and specific high‐performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) assay for the determination of rivastigmine and its major…”
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Determination of topotecan in human and mouse plasma and in mouse tissue homogenates by reversed-phase high-performance liquid chromatography by Vries, Nienke A. de, Ouwehand, Mariët, Buckle, Tessa, Beijnen, Jos H., van Tellingen, Olaf

“…A sensitive and selective reversed‐phase high‐performance liquid chromatographic (HPLC) assay has been developed and validated for quantification of total…”
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Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir by BARDELMEIJER, Heleen A, OUWEHAND, Mariët, BUCKLE, Tessa, HUISMAN, Maarten T, SCHELLENS, Jan H. M, BEIJNEN, Jos H, VAN TELLINGEN, Olaf

“…P-glycoprotein seems to be the most important factor limiting the oral absorption of paclitaxel. We have now explored the mechanisms responsible for the low…”
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Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut by BARDELMEIJER, Heleen A, OUWEHAND, Mariët, MALINGRE, Mirte M, SCHELLENS, Jan H. M, BEIJNEN, Jos H, VAN TELLINGEN, Olaf

“…Recent studies in mice and patients have shown that the low oral bioavailability of paclitaxel can be increased by coadministration of P-glycoprotein blockers…”
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Quantitative analysis of D-24851, a novel anticancer agent, in human plasma and urine by liquid chromatography coupled with tandem mass spectrometry by Stokvis, Ellen, Nan-Offeringa, Lianda G. A. H., Ouwehand, Mariët, Tibben, Matthijs M., Rosing, Hilde, Schnaars, Yvonne, Grigat, Martina, Romeis, Peter, Schellens, Jan H. M., Beijnen, Jos H.

“…The development of a liquid chromatography/tandem mass spectrometric assay for the quantitative analysis of the novel tubulin inhibitor D‐24851 in human plasma…”
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Trabectedin (ET-743, Yondelis) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype by Beumer, Jan-Hendrik, Buckle, Tessa, Ouwehand, Mariet, Franke, Niels E F, Lopez-Lazaro, Luis, Schellens, Jan H M, Beijnen, Jos H, van Tellingen, Olaf

“…Trabectedin (ET-743, Yondelis) is a novel anticancer drug currently undergoing phase II and III investigations. There are various and conflicting reports…”
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Letter to the Editor by Olaf van Tellingen, Bardelmeijer, Heleen A, Buckle, Tessa, Ouwehand, Mariet

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Cannulation of the jugular vein in mice by van Tellingen, Olaf, Bardelmeijer, Heleen A, Buckle, Tessa, Ouwehand, Mariet, Beijnen, Jos H, Schellens, Jan H M

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Determination of cyclosporin A in human and mouse plasma by reversed-phase high-performance liquid chromatography by Bardelmeijer, Heleen A., Ouwehand, Mariët, Beijnen, Jos H., Schellens, Jan H.M., van Tellingen, Olaf

“…An isocratic reversed-phase high-performance liquid chromatographic method with ultraviolet detection at 227 nm has been validated for the determination of…”
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