Search Results - "OTTMAR JANSSEN"

Intra- and Extracellular Effector Vesicles From Human T And NK Cells: Same-Same, but Different? by Lettau, Marcus, Janssen, Ottmar

“…Cytotoxic T lymphocytes (CTL) and Natural Killer (NK) cells utilize an overlapping effector arsenal for the elimination of target cells. It was initially…”
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Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage by Cohnen, André, Chiang, Samuel C., Stojanovic, Ana, Schmidt, Hendrik, Claus, Maren, Saftig, Paul, Janßen, Ottmar, Cerwenka, Adelheid, Bryceson, Yenan T., Watzl, Carsten

“…Cytotoxic lymphocytes are important for immune responses against viral infections and cancer. They are able to kill target cells through the release of…”
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Shedding of endogenous MHC class I‐related chain molecules A and B from different human tumor entities: Heterogeneous involvement of the “a disintegrin and metalloproteases” 10 and 17 by Chitadze, Guranda, Lettau, Marcus, Bhat, Jaydeep, Wesch, Daniela, Steinle, Alexander, Fürst, Daniel, Mytilineos, Joannis, Kalthoff, Holger, Janssen, Ottmar, Oberg, Hans‐Heinrich, Kabelitz, Dieter

“…The interaction of the MHC class I‐related chain molecules A and B (MICA and MICB) with the corresponding natural killer group 2, member D (NKG2D) receptor…”
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Degranulation of human cytotoxic lymphocytes is a major source of proteolytically active soluble CD26/DPP4 by Lettau, Marcus, Dietz, Michelle, Vollmers, Sarah, Armbrust, Fred, Peters, Christian, Dang, Thi Mai, Chitadze, Guranda, Kabelitz, Dieter, Janssen, Ottmar

“…Dipeptidyl peptidase 4 (DPP4, CD26) is a serine protease detected on several immune cells and on epithelial cells of various organs. Besides the membrane-bound…”
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Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10) by Ebsen, Henriette, Lettau, Marcus, Kabelitz, Dieter, Janssen, Ottmar

“…The a disintegrin and metalloproteases (ADAMs) play a pivotal role in the control of development, adhesion, migration, inflammation and cancer. Although…”
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Comparative Analysis of Extracellular Vesicles from Cytotoxic CD8 + αβ T Cells and γδ T Cells by Griesel, Lisa, Kaleja, Patrick, Tholey, Andreas, Lettau, Marcus, Janssen, Ottmar

“…Although belonging to different branches of the immune system, cytotoxic CD8 αβ T cells and γδ T cells utilize common cytolytic effectors including FasL,…”
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Analysis of Cytotoxic Granules and Constitutively Produced Extracellular Vesicles from Large Granular Lymphocytic Leukemia Cell Lines by Ploeger, Lara, Kaleja, Patrick, Tholey, Andreas, Lettau, Marcus, Janssen, Ottmar

“…Large granular lymphocyte leukemias (LGLLs) are rare lymphoproliferative malignancies caused by clonal expansion of granular lymphocytes. T-cell LGLL and…”
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Pro- and anti-apoptotic CD95 signaling in T cells by Paulsen, Maren, Janssen, Ottmar

“…The TNF receptor superfamily member CD95 (Fas, APO-1, TNFRSF6) is known as the prototypic death receptor in and outside the immune system. In fact, many…”
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TGF-β enhances the cytotoxic activity of Vδ2 T cells by Peters, Christian, Meyer, Annika, Kouakanou, Léonce, Feder, Julia, Schricker, Tim, Lettau, Marcus, Janssen, Ottmar, Wesch, Daniela, Kabelitz, Dieter

“…TGF-β is a pleiotropic cytokine with multiple roles in immunity. Apart from its suppressive activity, TGF-β is a driving cytokine in the differentiation of…”
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Differential surface expression of ADAM10 and ADAM17 on human T lymphocytes and tumor cells by Ebsen, Henriette, Schröder, Alexandra, Kabelitz, Dieter, Janssen, Ottmar

“…A disintegrin and metalloproteases (ADAMs) have been implicated in many processes controlling organismic development and integrity. Important substrates of…”
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Sequential Treatment with Temozolomide Plus Naturally Derived AT101 as an Alternative Therapeutic Strategy: Insights into Chemoresistance Mechanisms of Surviving Glioblastoma Cells by Hellmold, Dana, Kubelt, Carolin, Daunke, Tina, Beckinger, Silje, Janssen, Ottmar, Hauck, Margarethe, Schütt, Fabian, Adelung, Rainer, Lucius, Ralph, Haag, Jochen, Sebens, Susanne, Synowitz, Michael, Held-Feindt, Janka

“…Glioblastoma (GBM) is a poorly treatable disease due to the fast development of tumor recurrences and high resistance to chemo- and radiotherapy. To overcome…”
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Immunosurveillance by human γδ T lymphocytes: the emerging role of butyrophilins [version 1; peer review: 2 approved] by Kabelitz, Dieter, Lettau, Marcus, Janssen, Ottmar

“…In contrast to conventional T lymphocytes, which carry an αβ T-cell receptor and recognize antigens as peptides presented by major histocompatibility complex…”
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Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells by Lettau, Marcus, Armbrust, Fred, Dohmen, Katharina, Drews, Lisann, Poch, Tobias, Dietz, Michelle, Kabelitz, Dieter, Janssen, Ottmar

“…Abstract It is widely accepted that cytotoxic T and NK cells store effector proteins including granzymes, perforin and Fas ligand (FasL) in intracellular…”
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NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human γδ T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors by Chitadze, Guranda, Lettau, Marcus, Luecke, Stefanie, Wang, Ting, Janssen, Ottmar, Fürst, Daniel, Mytilineos, Joannis, Wesch, Daniela, Oberg, Hans-Heinrich, Held-Feindt, Janka, Kabelitz, Dieter

“…The interaction of the MHC class I-related chain molecules A and B (MICA and MICB) and UL-16 binding protein (ULBP) family members expressed on tumor cells…”
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Analysis of the Seasonal Fluctuation of γδ T Cells and Its Potential Relation with Vitamin D3 by Bernicke, Birthe, Engelbogen, Nils, Klein, Katharina, Franzenburg, Jeanette, Borzikowsky, Christoph, Peters, Christian, Janssen, Ottmar, Junker, Ralf, Serrano, Ruben, Kabelitz, Dieter

“…In addition to its role in bone metabolism, vitamin D3 exerts immunomodulatory effects and has been proposed to contribute to seasonal variation of immune…”
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In-depth immunophenotyping of patients with glioblastoma multiforme: Impact of steroid treatment by Chitadze, Guranda, Flüh, Charlotte, Quabius, Elgar Susanne, Freitag-Wolf, Sandra, Peters, Christian, Lettau, Marcus, Bhat, Jaydeep, Wesch, Daniela, Oberg, Hans-Heinrich, Luecke, Stefanie, Janssen, Ottmar, Synowitz, Michael, Held-Feindt, Janka, Kabelitz, Dieter

“…Despite aggressive treatment regimens based on surgery and radiochemotherapy, the prognosis of patients with grade IV glioblastoma multiforme (GBM) remains…”
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Nck adapter proteins: functional versatility in T cells by Lettau, Marcus, Pieper, Jennifer, Janssen, Ottmar

“…Nck is a ubiquitously expressed adapter protein that is almost exclusively built of one SH2 domain and three SH3 domains. The two isoproteins of Nck are…”
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Storage, expression and function of Fas ligand, the key death factor of immune cells by Lettau, Marcus, Paulsen, Maren, Kabelitz, Dieter, Janssen, Ottmar

“…The TNF family member Fas ligand (FasL) induces apoptosis in Fas-expressing cells and serves as a key death factor in the immune system. It is involved in the…”
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Role of caspases in CD95-induced biphasic activation of acid sphingomyelinase by Stephan, Mario, Edelmann, Bärbel, Winoto-Morbach, Supandi, Janssen, Ottmar, Bertsch, Uwe, Perrotta, Cristiana, Schütze, Stefan, Fritsch, Jürgen

“…Acid sphingomyelinase (A-SMase) plays an important role in the initiation of CD95 signaling by forming ceramide-enriched membrane domains that enable…”
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Stromal cells support the survival of human primary chronic lymphocytic leukemia (CLL) cells through Lyn-driven extracellular vesicles by de Oliveira, Thaís Dolzany, Vom Stein, Alexander, Rebollido-Rios, Rocio, Lobastova, Liudmila, Lettau, Marcus, Janssen, Ottmar, Wagle, Prerana, Nguyen, Phuong-Hien, Hallek, Michael, Hansen, Hinrich P

“…In chronic lymphocytic leukemia (CLL), the tumor cells receive survival support from stromal cells through direct cell contact, soluble factors and…”
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