Search Results - "OTIS, S"

Circuit Mechanisms Underlying Motor Memory Formation in the Cerebellum by Lee, Ka Hung, Mathews, Paul J., Reeves, Alexander, Choe, Katrina Y., Jami, Shekib A., Serrano, Raul E., Otis, Thomas S.

“…The cerebellum stores associative motor memories essential for properly timed movement; however, the mechanisms by which these memories form and are acted upon…”
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Adeno-Associated Virus Toolkit to Target Diverse Brain Cells by Challis, Rosemary C, Ravindra Kumar, Sripriya, Chen, Xinhong, Goertsen, David, Coughlin, Gerard M, Hori, Acacia M, Chuapoco, Miguel R, Otis, Thomas S, Miles, Timothy F, Gradinaru, Viviana

“…Recombinant adeno-associated viruses (AAVs) are commonly used gene delivery vehicles for neuroscience research. They have two engineerable features: the capsid…”
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Cellular and circuit mechanisms underlying spinocerebellar ataxias by Meera, Pratap, Pulst, Stefan M., Otis, Thomas S.

“…Degenerative ataxias are a common form of neurodegenerative disease that affect about 20 individuals per 100,000. The autosomal dominant spinocerebellar…”
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Taurine in sports and exercise by Kurtz, Jennifer A, VanDusseldorp, Trisha A, Doyle, J Andrew, Otis, Jeffrey S

“…Taurine has become a popular supplement among athletes attempting to improve performance. While the effectiveness of taurine as an ergogenic aid remains…”
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Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion by Sareen, Dhruv, O'Rourke, Jacqueline G, Meera, Pratap, Muhammad, A K M G, Grant, Sharday, Simpkinson, Megan, Bell, Shaughn, Carmona, Sharon, Ornelas, Loren, Sahabian, Anais, Gendron, Tania, Petrucelli, Leonard, Baughn, Michael, Ravits, John, Harms, Matthew B, Rigo, Frank, Bennett, C Frank, Otis, Thomas S, Svendsen, Clive N, Baloh, Robert H

“…Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative condition characterized by loss of motor neurons in the brain and spinal cord. Expansions of…”
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Intermittent Pneumatic Compression of the Upper Extremity for Postoperative Deep Venous Thrombosis Prophylaxis: A Pilot Randomized Trial by John, Preeti R, Apau, Otis S, Dosi, Garima, Lal, Brajesh K

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The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function by Gehman, Lauren T, Meera, Pratap, Stoilov, Peter, Shiue, Lily, O'Brien, Janelle E, Meisler, Miriam H, Ares, Jr, Manuel, Otis, Thomas S, Black, Douglas L

“…The Rbfox proteins (Rbfox1, Rbfox2, and Rbfox3) regulate the alternative splicing of many important neuronal transcripts and have been implicated in a variety…”
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Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2 by Hansen, Stephen T, Meera, Pratap, Otis, Thomas S, Pulst, Stefan M

“…Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited disorder, which is caused by a pathological expansion of a polyglutamine (polyQ)…”
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Holographic photolysis of caged neurotransmitters by Emiliani, Valentina, Lutz, Christoph, Otis, Thomas S, DeSars, Vincent, Charpak, Serge, DiGregorio, David A

“…Holographic illumination allows the production of complex, user-defined, two-dimensional illumination patterns. Used to manipulate light-sensitive molecules in…”
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New roles for the cerebellum in health and disease by Reeber, Stacey L, Otis, Tom S, Sillitoe, Roy V

“…The cerebellum has a well-established role in maintaining motor coordination and studies of cerebellar learning suggest that it does this by recognizing neural…”
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Gene co-expression network analysis for identifying modules and functionally enriched pathways in SCA2 by Pflieger, Lance T, Dansithong, Warunee, Paul, Sharan, Scoles, Daniel R, Figueroa, Karla P, Meera, Pratap, Otis, Thomas S, Facelli, Julio C, Pulst, Stefan M

“…Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease caused by CAG repeat expansion in the ATXN2 gene. The repeat resides in…”
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Pro-inflammatory mediation of myoblast proliferation by Otis, Jeffrey S, Niccoli, Sarah, Hawdon, Nicole, Sarvas, Jessica L, Frye, Melinda A, Chicco, Adam J, Lees, Simon J

“…Skeletal muscle satellite cell function is largely dictated by the surrounding environment following injury. Immune cell infiltration dominates the…”
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Effects of climbing fiber driven inhibition on Purkinje neuron spiking by Mathews, Paul J, Lee, Ka Hung, Peng, Zechun, Houser, Carolyn R, Otis, Thomas S

“…Climbing fiber (CF) input to the cerebellum is thought to instruct associative motor memory formation through its effects on multiple sites within the…”
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Sensory nerve-mediated and nitric oxide-dependent cutaneous vasodilation in normotensive and prehypertensive non-Hispanic blacks and whites by Wong, Brett J, Turner, Casey G, Miller, James T, Walker, Demetria C, Sebeh, Yesser, Hayat, Matthew J, Otis, Jeffrey S, Quyyumi, Arshed A

“…The purpose of this study was to investigate the effect of race and subclinical elevations in blood pressure (i.e., prehypertension) on cutaneous sensory…”
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Excessive Ethanol Intake in Mice Does Not Impair Recovery of Torque after Repeated Bouts of Eccentric Contractions by MOSER, SAMANTHA E., BROWN, AUSTIN M., GANJAYI, MUNI SWAMY, OTIS, JEFFREY S., BAUMANN, CORY W.

“…Alcoholics develop muscle atrophy and weakness from excessive ethanol (EtOH) intake. To date, most research has examined outcomes of alcohol-induced atrophy…”
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Exercise as a community treatment for obesity and the metabolic disease epidemic by Scholler, John, Otis, Jeffrey S.

“…Abstract The obesity epidemic has continued to rise at an alarming rate and has increased health complications in children, adolescents, and adults. Resistance…”
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The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper by Lang, Eric J., Apps, Richard, Bengtsson, Fredrik, Cerminara, Nadia L, De Zeeuw, Chris I, Ebner, Timothy J., Heck, Detlef H., Jaeger, Dieter, Jörntell, Henrik, Kawato, Mitsuo, Otis, Thomas S., Ozyildirim, Ozgecan, Popa, Laurentiu S., Reeves, Alexander M. B., Schweighofer, Nicolas, Sugihara, Izumi, Xiao, Jianqiang

“…For many decades, the predominant view in the cerebellar field has been that the olivocerebellar system’s primary function is to induce plasticity in the…”
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Receptor protein tyrosine phosphatases control Purkinje neuron firing by Brown, Alexander S., Meera, Pratap, Quinones, Gabe, Magri, Jessica, Otis, Thomas S., Pulst, Stefan M., Oro, Anthony E.

“…Spinocerebellar ataxias (SCA) are a genetically heterogeneous family of cerebellar neurodegenerative diseases characterized by abnormal firing of Purkinje…”
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A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition by Santhakumar, Vijayalakshmi, Meera, Pratap, Karakossian, Movses H, Otis, Thomas S

“…GABAA receptors (GABARs) are the targets of a wide variety of modulatory drugs which enhance chloride flux through GABAR ion channels. Certain GABAR modulators…”
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Neuronal Glutamate Transporters Control Activation of Postsynaptic Metabotropic Glutamate Receptors and Influence Cerebellar Long-Term Depression by Brasnjo, Gabor, Otis, Thomas S.

“…Neuronal and glial isoforms of glutamate transporters show distinct distributions on membranes surrounding excitatory synapses, but specific roles for…”
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