Search Results - "OTAKE, Hiroyuki"

Tracing the emergence of a novel sex-determining gene in medaka, Oryzias luzonensis by Myosho, Taijun, Otake, Hiroyuki, Masuyama, Haruo, Matsuda, Masaru, Kuroki, Yoko, Fujiyama, Asao, Naruse, Kiyoshi, Hamaguchi, Satoshi, Sakaizumi, Mitsuru

“…Three sex-determining (SD) genes, SRY (mammals), Dmy (medaka), and DM-W (Xenopus laevis), have been identified to date in vertebrates. However, how and why a…”
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Contribution of Leydig and Sertoli Cells to Testosterone Production in Mouse Fetal Testes by Shima, Yuichi, Miyabayashi, Kanako, Haraguchi, Shogo, Arakawa, Tatsuhiko, Otake, Hiroyuki, Baba, Takashi, Matsuzaki, Sawako, Shishido, Yurina, Akiyama, Haruhiko, Tachibana, Taro, Tsutsui, Kazuyoshi, Morohashi, Ken-ichirou

“…Testosterone is a final product of androgenic hormone biosynthesis, and Leydig cells are known to be the primary source of androgens. In the mammalian testis,…”
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Fetal Leydig Cells Persist as an Androgen-Independent Subpopulation in the Postnatal Testis by Shima, Yuichi, Matsuzaki, Sawako, Miyabayashi, Kanako, Otake, Hiroyuki, Baba, Takashi, Kato, Shigeaki, Huhtaniemi, Ilpo, Morohashi, Ken-ichirou

“…Two distinct types of Leydig cells emerge during the development of eutherian mammals. Fetal Leydig cells (FLCs) appear shortly after gonadal sex…”
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Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor by Ramkumar, Kavya, Samanta, Soma, Kyani, Anahita, Yang, Suhui, Tamura, Shuzo, Ziemke, Elizabeth, Stuckey, Jeanne A., Li, Si, Chinnaswamy, Krishnapriya, Otake, Hiroyuki, Debnath, Bikash, Yarovenko, Vladimir, Sebolt-Leopold, Judith S., Ljungman, Mats, Neamati, Nouri

“…Glutathione S -transferase omega 1 (GSTO1) is an atypical GST isoform that is overexpressed in several cancers and has been implicated in drug resistance…”
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Physiological and subjective comfort evaluation under different airflow directions in a cooling environment by Tamura, Kaori, Matsumoto, Sayaka, Tseng, Yu Hsuan, Kobayashi, Takayuki, Miwa, Jun'ichi, Miyazawa, Ken'ichi, Hirao, Toyotaka, Matsumoto, Soichiro, Hiramatsu, Seiji, Otake, Hiroyuki, Okamoto, Tsuyoshi

“…Indoor comfort is influenced by airflow direction, but subjective evaluations can differ. This study evaluates the airflow comfort with subjective assessments…”
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Heterogeneity of ovarian theca and interstitial gland cells in mice by Miyabayashi, Kanako, Tokunaga, Kaori, Otake, Hiroyuki, Baba, Takashi, Shima, Yuichi, Morohashi, Ken-Ichirou

“…It has been established that two developmentally and functionally distinct cell types emerge within the mammalian testis and adrenal gland throughout life…”
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Identification of an Enhancer in the Ad4BP/SF-1 Gene Specific for Fetal Leydig Cells by Shima, Yuichi, Miyabayashi, Kanako, Baba, Takashi, Otake, Hiroyuki, Oka, Sanae, Zubair, Mohamad, Morohashi, Ken-ichirou

“…Adrenal 4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) (Nr5a1) is a nuclear receptor essential for reproductive tissue development and endocrine…”
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Physiological comfort evaluation under different airflow directions in a heating environment by Tamura, Kaori, Matsumoto, Sayaka, Tseng, Yu Hsuan, Kobayashi, Takayuki, Miwa, Jun'ichi, Miyazawa, Ken'ichi, Matsumoto, Soichiro, Hiramatsu, Seiji, Otake, Hiroyuki, Okamoto, Tsuyoshi

“…Indoor airflow and thermal comfort are difficult to assess through subjective evaluations because airflow sensations can differ based on various factors, such…”
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Combination use of liraglutide and insulin to Japanese patients with multiple insulin injection: efficacy and cost by Houda, Sellami-Mnif, Toshihiro, Umehara, Yuriko, Yamazaki, Hiroyuki, Otake, Reie, Matoba, Anna, Sakashita, Masafumi, Matsuda

“…Objectives The introduction of liraglutide in the treatment of patients with type 2 diabetes already taking insulin is still subject to discussion in terms of…”
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Effects of high temperature on sex differentiation and germ cell population in medaka, Oryzias latipes by Selim, Khaled M., Shinomiya, Ai, Otake, Hiroyuki, Hamaguchi, Satoshi, Sakaizumi, Mitsuru

“…Medaka, Oryzias latipes, has an XX/XY sex determination system with DMY as the sex-determining gene. Previous studies have confirmed that the process of sex…”
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Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids by Baba, Takashi, Otake, Hiroyuki, Inoue, Miki, Sato, Tetsuya, Ishihara, Yasuhiro, Moon, Ju-Yeon, Tsuchiya, Megumi, Miyabayashi, Kanako, Ogawa, Hidesato, Shima, Yuichi, Wang, Lixiang, Sato, Ryuichiro, Yamazaki, Takeshi, Suyama, Mikita, Nomura, Masatoshi, Choi, Man Ho, Ohkawa, Yasuyuki, Morohashi, Ken-ichirou

“…Housekeeping metabolic pathways such as glycolysis are active in all cell types. In addition, many types of cells are equipped with cell-specific metabolic…”
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Wild-Derived XY Sex-Reversal Mutants in the Medaka, Oryzias latipes by Otake, Hiroyuki, Shinomiya, Ai, Matsuda, Masaru, Hamaguchi, Satoshi, Sakaizumi, Mitsuru

“…The medaka, Oryzias latipes, has an XX/XY sex-determination mechanism. A Y-linked DM domain gene, DMY, has been isolated by positional cloning as a…”
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The medaka sex-determining gene DMY acquired a novel temporal expression pattern after duplication of DMRT1 by Otake, Hiroyuki, Shinomiya, Ai, Kawaguchi, Aya, Hamaguchi, Satoshi, Sakaizumi, Mitsuru

“…The male sex‐determining gene, DMY, of the medaka is considered to have arisen via gene duplication of DMRT1. In the medaka, both genes are expressed in…”
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Field survey of sex-reversals in the medaka, Oryzias latipes: genotypic sexing of wild populations by Shinomiya, Ai, Otake, Hiroyuki, Togashi, Ken-ichi, Hamaguchi, Satoshi, Sakaizumi, Mitsuru

“…The medaka, Oryzias latipes, has an XX/XY sex determination mechanism. A Y-linked DM domain gene, DMY, has been isolated by positional cloning as a prime…”
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Fragment-Based Discovery of 8‑Hydroxyquinoline Inhibitors of the HIV‑1 Integrase–Lens Epithelium-Derived Growth Factor/p75 (IN–LEDGF/p75) Interaction by Serrao, Erik, Debnath, Bikash, Otake, Hiroyuki, Kuang, Yuting, Christ, Frauke, Debyser, Zeger, Neamati, Nouri

“…On the basis of an initial molecular modeling study suggesting the favorable binding of the “privileged” fragment 8-hydroxyquinoline with HIV-1 integrase (IN)…”
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Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones by Katoh-Fukui, Yuko, Baba, Takashi, Sato, Tetsuya, Otake, Hiroyuki, Nagakui-Noguchi, Yuko, Shindo, Miyuki, Suyama, Mikita, Ohkawa, Yasuyuki, Tsumura, Hideki, Morohashi, Ken-ichirou, Fukami, Maki

“…A set of key developmental genes is essential for skeletal growth from multipotent progenitor cells at weaning. Polycomb group proteins, which regulate such…”
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Discovery of novel inhibitors of LEDGF/p75-IN protein–protein interactions by Sanchez, Tino Wilson, Debnath, Bikash, Christ, Frauke, Otake, Hiroyuki, Debyser, Zeger, Neamati, Nouri

“…Human lens epithelium-derived growth factor (LEDGF)/p75 plays an important role in the HIV life cycle by stimulating integrase (IN)-led viral DNA integration…”
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Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1 by Baba, Takashi, Otake, Hiroyuki, Sato, Tetsuya, Miyabayashi, Kanako, Shishido, Yurina, Wang, Chia-Yih, Shima, Yuichi, Kimura, Hiroshi, Yagi, Mikako, Ishihara, Yasuhiro, Hino, Shinjiro, Ogawa, Hidesato, Nakao, Mitsuyoshi, Yamazaki, Takeshi, Kang, Dongchon, Ohkawa, Yasuyuki, Suyama, Mikita, Chung, Bon-Chu, Morohashi, Ken-Ichirou

“…Genetic deficiencies in transcription factors can lead to the loss of certain types of cells and tissue. The steroidogenic tissue-specific nuclear receptor…”
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Fragment-Based Discovery of 8-Hydroxyquinoline Inhibitors of the HIV-1 Integrase-LEDGF/p75 Interaction by Serrao, Erik, Debnath, Bikash, Otake, Hiroyuki, Kuang, Yuting, Christ, Frauke, Debyser, Zeger, Neamati, Nouri

“…On the basis of an initial molecular modeling study suggesting the favorable binding of the “privileged” fragment 8-hydroxyquinoline with IN at the…”
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Discovery of novel inhibitors of LEDGF/p75-IN proteinaprotein interactions by Sanchez, Tino Wilson, Debnath, Bikash, Christ, Frauke, Otake, Hiroyuki, Debyser, Zeger, Neamati, Nouri

“…Human lens epithelium-derived growth factor (LEDGF)/p75 plays an important role in the HIV life cycle by stimulating integrase (IN)-led viral DNA integration…”
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