Search Results - "OSTER, Alexander"

Circulating HIV-Specific Interleukin-21+CD4+ T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions by Schultz, Bruce T., Teigler, Jeffrey E., Pissani, Franco, Oster, Alexander F., Kranias, Gregory, Alter, Galit, Marovich, Mary, Eller, Michael A., Dittmer, Ulf, Robb, Merlin L., Kim, Jerome H., Michael, Nelson L., Bolton, Diane, Streeck, Hendrik

“…A central effort in HIV vaccine development is to generate protective broadly neutralizing antibodies, a process dependent on T follicular helper (Tfh) cells…”
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Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia by Johnson, Susan, Eller, Michael, Teigler, Jeffrey E, Maloveste, Sebastien M, Schultz, Bruce T, Soghoian, Damien Z, Lu, Richard, Oster, Alexander F, Chenine, Agnès-Laurence, Alter, Galit, Dittmer, Ulf, Marovich, Mary, Robb, Merlin L, Michael, Nelson L, Bolton, Diane, Streeck, Hendrik

“…CD4+ T cells play a pivotal role in the control of chronic viral infections. Recently, nontraditional CD4+ T cell functions beyond helper effects have been…”
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Induction of Gag-specific CD4 T cell responses during acute HIV infection is associated with improved viral control by Schieffer, Miriam, Jessen, Heiko K, Oster, Alexander F, Pissani, Franco, Soghoian, Damien Z, Lu, Richard, Jessen, Arne B, Zedlack, Carmen, Schultz, Bruce T, Davis, Isaiah, Ranasinghe, Srinika, Rosenberg, Eric S, Alter, Galit, Schumann, Ralf R, Streeck, Hendrik

“…Effector CD4 T cell responses have been shown to be critically involved in the containment and clearance of viral pathogens. However, their involvement in the…”
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17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: Protein structures, functions, and recent progress in inhibitor development by Marchais-Oberwinkler, Sandrine, Henn, Claudia, Möller, Gabriele, Klein, Tobias, Negri, Matthias, Oster, Alexander, Spadaro, Alessandro, Werth, Ruth, Wetzel, Marie, Xu, Kuiying, Frotscher, Martin, Hartmann, Rolf W., Adamski, Jerzy

“…17β-Hydroxysteroid dehydrogenases (17β-HSDs) are oxidoreductases, which play a key role in estrogen and androgen steroid metabolism by catalyzing final steps…”
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New Insights into the SAR and Binding Modes of Bis(hydroxyphenyl)thiophenes and -benzenes: Influence of Additional Substituents on 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitory Activity and Selectivity by Bey, Emmanuel, Marchais-Oberwinkler, Sandrine, Negri, Matthias, Kruchten, Patricia, Oster, Alexander, Klein, Tobias, Spadaro, Alessandro, Werth, Ruth, Frotscher, Martin, Birk, Barbara, Hartmann, Rolf W

“…17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is responsible for the catalytic reduction of weakly active E1 to highly potent E2. E2 stimulates the…”
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Design, Synthesis, Biological Evaluation and Pharmacokinetics of Bis(hydroxyphenyl) substituted Azoles, Thiophenes, Benzenes, and Aza-Benzenes as Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) by Bey, Emmanuel, Marchais-Oberwinkler, Sandrine, Werth, Ruth, Negri, Matthias, Al-Soud, Yaseen A, Kruchten, Patricia, Oster, Alexander, Frotscher, Martin, Birk, Barbara, Hartmann, Rolf W

“…17β-Estradiol (E2), the most potent female sex hormone, stimulates the growth of mammary tumors and endometriosis via activation of the estrogen receptor α…”
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Bicyclic Substituted Hydroxyphenylmethanones as Novel Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) for the Treatment of Estrogen-Dependent Diseases by Oster, Alexander, Hinsberger, Stefan, Werth, Ruth, Marchais-Oberwinkler, Sandrine, Frotscher, Martin, Hartmann, Rolf W

“…Estradiol (E2), the most important estrogen in humans, is involved in the initiation and progression of estrogen-dependent diseases such as breast cancer and…”
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Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseases by Bey, Emmanuel, Marchais-Oberwinkler, Sandrine, Kruchten, Patricia, Frotscher, Martin, Werth, Ruth, Oster, Alexander, Algül, Oztekin, Neugebauer, Alexander, Hartmann, Rolf W.

“…A series of 19 azoles were synthesised and 17β-HSD1 inhibition determined. Compound 18 showed highest activity in cell free and T-47D assays, excellent…”
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Novel estrone mimetics with high 17β-HSD1 inhibitory activity by Oster, Alexander, Klein, Tobias, Werth, Ruth, Kruchten, Patricia, Bey, Emmanuel, Negri, Matthias, Marchais-Oberwinkler, Sandrine, Frotscher, Martin, Hartmann, Rolf W.

“…Estrone mimetics were synthesized and 17β-HSD1 inhibition was determined. Compound 12 showed high inhibitory activity, selectivity toward 17β-HSD2, ERα/ERβ and…”
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Selective inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17βHSD1) reduces estrogen responsive cell growth of T47-D breast cancer cells by Kruchten, Patricia, Werth, Ruth, Bey, Emmanuel, Oster, Alexander, Marchais-Oberwinkler, Sandrine, Frotscher, Martin, Hartmann, Rolf W.

“…The most potent estrogen estradiol (E2) plays a pivotal role in the initiation and progression of estrogen dependent diseases. 17β-Hydroxysteroid dehydrogenase…”
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Bicyclic Substituted Hydroxyphenylmethanone Type Inhibitors of 17 beta -Hydroxysteroid Dehydrogenase Type1 (17 beta -HSD1): The Role of the Bicyclic Moiety by Oster, Alexander, Klein, Tobias, Henn, Claudia, Werth, Ruth, Marchais-Oberwinkler, Sandrine, Frotscher, Martin, Hartmann, Rolf W

“…An attractive target that has still to be explored for the treatment of estrogen-dependent diseases, such as breast cancer and endometriosis, is the enzyme…”
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The role of the heterocycle in bis(hydroxyphenyl)triazoles for inhibition of 17β-Hydroxysteroid Dehydrogenase (17β-HSD) type 1 and type 2 by Al-Soud, Yaseen A., Bey, Emmanuel, Oster, Alexander, Marchais-Oberwinkler, Sandrine, Werth, Ruth, Kruchten, Patricia, Frotscher, Martin, Hartmann, Rolf W.

“…17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is responsible for the catalytic reduction of the weak estrogen estrone (E1) into the highly potent…”
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Bicyclic Substituted Hydroxyphenylmethanone Type Inhibitors of 17 β-Hydroxysteroid Dehydrogenase Type 1 (17 β-HSD1): The Role of the Bicyclic Moiety by Oster, Alexander, Klein, Tobias, Henn, Claudia, Werth, Ruth, Marchais-Oberwinkler, Sandrine, Frotscher, Martin, Hartmann, Rolf W.

“…An attractive target that has still to be explored for the treatment of estrogen‐dependent diseases, such as breast cancer and endometriosis, is the enzyme…”
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Bicyclic Substituted Hydroxyphenylmethanone Type Inhibitors of 17[beta]-Hydroxysteroid Dehydrogenase Type1 (17[beta]-HSD1): The Role of the Bicyclic Moiety by Oster, Alexander, Klein, Tobias, Henn, Claudia, Werth, Ruth, Marchais-Oberwinkler, Sandrine, Frotscher, Martin, Hartmann, Rolf W

“…An attractive target that has still to be explored for the treatment of estrogen-dependent diseases, such as breast cancer and endometriosis, is the enzyme…”
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The role of the heterocycle in bis(hydroxyphenyl)triazoles for inhibition of 17beta-Hydroxysteroid Dehydrogenase (17beta-HSD) type 1 and type 2 by Al-Soud, Yaseen A, Bey, Emmanuel, Oster, Alexander, Marchais-Oberwinkler, Sandrine, Werth, Ruth, Kruchten, Patricia, Frotscher, Martin, Hartmann, Rolf W

“…17beta-Hydroxysteroid dehydrogenase type 1 (17beta-HSD1) is responsible for the catalytic reduction of the weak estrogen estrone (E1) into the highly potent…”
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17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: Protein structures, functions, and recent progress in inhibitor development: Targeted Inhibitors for Steroid Transforming Enzymes by MARCHAIS-OBERWINKLER, Sandrine, HENN, Claudia, FROTSCHER, Martin, HARTMANN, Rolf W, ADAMSKI, Jerzy, MÖLLER, Gabriele, KLEIN, Tobias, NEGRI, Matthias, OSTER, Alexander, SPADARO, Alessandro, WERTH, Ruth, WETZEL, Marie, KUIYING XU

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Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17p-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseases by BEY, Emmanuel, MARCHAIS-OBERWINKLER, Sandrine, KRUCHTEN, Patricia, FROTSCHER, Martin, WERTH, Ruth, OSTER, Alexander, ALGÜL, Oztekin, NEUGEBAUER, Alexander, HARTMANN, Rolf W

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Novel estrone mimetics with high 17beta-HSD1 inhibitory activity by Oster, Alexander, Klein, Tobias, Werth, Ruth, Kruchten, Patricia, Bey, Emmanuel, Negri, Matthias, Marchais-Oberwinkler, Sandrine, Frotscher, Martin, Hartmann, Rolf W

“…17Beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) catalyzes the reduction of estrone into estradiol, which is the most potent estrogen in humans…”
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Selective inhibition of 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) reduces estrogen responsive cell growth of T47-D breast cancer cells by Kruchten, Patricia, Werth, Ruth, Bey, Emmanuel, Oster, Alexander, Marchais-Oberwinkler, Sandrine, Frotscher, Martin, Hartmann, Rolf W

“…The most potent estrogen estradiol (E2) plays a pivotal role in the initiation and progression of estrogen dependent diseases. 17beta-Hydroxysteroid…”
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New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity by Bey, Emmanuel, Marchais-Oberwinkler, Sandrine, Negri, Matthias, Kruchten, Patricia, Oster, Alexander, Klein, Tobias, Spadaro, Alessandro, Werth, Ruth, Frotscher, Martin, Birk, Barbara, Hartmann, Rolf W

“…17beta-Hydroxysteroid dehydrogenase type 1 (17beta-HSD1) is responsible for the catalytic reduction of weakly active E1 to highly potent E2. E2 stimulates the…”
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