Search Results - "OSTANO, Paola"

Dualism of FGF and TGF-β Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical Determinant by Bordignon, Pino, Bottoni, Giulia, Xu, Xiaoying, Popescu, Alma S., Truan, Zinnia, Guenova, Emmanuella, Kofler, Lukas, Jafari, Paris, Ostano, Paola, Röcken, Martin, Neel, Victor, Dotto, G. Paolo

“…Heterogeneity of cancer-associated fibroblasts (CAFs) can result from activation of distinct signaling pathways. We show that in primary human dermal…”
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Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer by Di Mitri, Diletta, Mirenda, Michela, Vasilevska, Jelena, Calcinotto, Arianna, Delaleu, Nicolas, Revandkar, Ajinkya, Gil, Veronica, Boysen, Gunther, Losa, Marco, Mosole, Simone, Pasquini, Emiliano, D’Antuono, Rocco, Masetti, Michela, Zagato, Elena, Chiorino, Giovanna, Ostano, Paola, Rinaldi, Andrea, Gnetti, Letizia, Graupera, Mariona, Martins Figueiredo Fonseca, Ana Raquel, Pereira Mestre, Ricardo, Waugh, David, Barry, Simon, De Bono, Johann, Alimonti, Andrea

“…Tumor-associated macrophages (TAMs) represent a major component of the tumor microenvironment supporting tumorigenesis. TAMs re-education has been proposed as…”
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Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation by Procopio, Maria-Giuseppina, Laszlo, Csaba, Al Labban, Dania, Kim, Dong Eun, Bordignon, Pino, Jo, Seung-Hee, Goruppi, Sandro, Menietti, Elena, Ostano, Paola, Ala, Ugo, Provero, Paolo, Hoetzenecker, Wolfram, Neel, Victor, Kilarski, Witold W., Swartz, Melody A., Brisken, Cathrin, Lefort, Karine, Dotto, G. Paolo

“…Stromal fibroblast senescence has been linked to ageing-associated cancer risk. However, density and proliferation of cancer-associated fibroblasts (CAFs) are…”
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Androgen receptor is a determinant of melanoma targeted drug resistance by Samarkina, Anastasia, Youssef, Markus Kirolos, Ostano, Paola, Ghosh, Soumitra, Ma, Min, Tassone, Beatrice, Proust, Tatiana, Chiorino, Giovanna, Levesque, Mitchell P., Goruppi, Sandro, Dotto, Gian Paolo

“…Melanoma provides a primary benchmark for targeted drug therapy. Most melanomas with BRAF V600 mutations regress in response to BRAF/MEK inhibitors…”
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Multifocal Epithelial Tumors and Field Cancerization from Loss of Mesenchymal CSL Signaling by Hu, Bing, Castillo, Einar, Harewood, Louise, Ostano, Paola, Reymond, Alexandre, Dummer, Reinhard, Raffoul, Wassim, Hoetzenecker, Wolfram, Hofbauer, Günther F.L., Dotto, G. Paolo

“…It is currently unclear whether tissue changes surrounding multifocal epithelial tumors are a cause or consequence of cancer. Here, we provide evidence that…”
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Castration-Induced Downregulation of SPARC in Stromal Cells Drives Neuroendocrine Differentiation of Prostate Cancer by Enriquez, Claudia, Cancila, Valeria, Ferri, Renata, Sulsenti, Roberta, Fischetti, Irene, Milani, Matteo, Ostano, Paola, Gregnanin, Ilaria, Mello-Grand, Maurizia, Berrino, Enrico, Bregni, Marco, Renne, Giuseppe, Tripodo, Claudio, Colombo, Mario P, Jachetti, Elena

“…Fatal neuroendocrine differentiation (NED) of castration-resistant prostate cancer is a recurrent mechanism of resistance to androgen deprivation therapies…”
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Patient-derived ovarian tumor xenografts recapitulate human clinicopathology and genetic alterations by Ricci, Francesca, Bizzaro, Francesca, Cesca, Marta, Guffanti, Federica, Ganzinelli, Monica, Decio, Alessandra, Ghilardi, Carmen, Perego, Patrizia, Fruscio, Robert, Buda, Alessandro, Milani, Rodolfo, Ostano, Paola, Chiorino, Giovanna, Bani, Maria Rosa, Damia, Giovanna, Giavazzi, Raffaella

“…Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. On the basis of its histopathology and molecular-genomic changes, ovarian cancer has…”
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ANKRD1 is a mesenchymal-specific driver of cancer-associated fibroblast activation bridging androgen receptor loss to AP-1 activation by Mazzeo, Luigi, Ghosh, Soumitra, Di Cicco, Emery, Isma, Jovan, Tavernari, Daniele, Samarkina, Anastasia, Ostano, Paola, Youssef, Markus K., Simon, Christian, Dotto, G. Paolo

“…There are significant commonalities among several pathologies involving fibroblasts, ranging from auto-immune diseases to fibrosis and cancer. Early steps in…”
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Nuclear lamin A/C phosphorylation by loss of androgen receptor leads to cancer-associated fibroblast activation by Ghosh, Soumitra, Isma, Jovan, Ostano, Paola, Mazzeo, Luigi, Toniolo, Annagiada, Das, Monalisa, White, Joni R., Simon, Christian, Paolo Dotto, G.

“…Alterations in nuclear structure and function are hallmarks of cancer cells. Little is known about these changes in Cancer-Associated Fibroblasts (CAFs),…”
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NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin by Katarkar, Atul, Bottoni, Giulia, Clocchiatti, Andrea, Goruppi, Sandro, Bordignon, Pino, Lazzaroni, Francesca, Gregnanin, Ilaria, Ostano, Paola, Neel, Victor, Dotto, G. Paolo

“…Cancer associated fibroblasts (CAFs) are a key component of the tumor microenvironment. Genomic alterations in these cells remain a point of contention. We…”
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Engineering an Environment for the Study of Fibrosis: A 3D Human Muscle Model with Endothelium Specificity and Endomysium by Bersini, Simone, Gilardi, Mara, Ugolini, Giovanni S., Sansoni, Veronica, Talò, Giuseppe, Perego, Silvia, Zanotti, Simona, Ostano, Paola, Mora, Marina, Soncini, Monica, Vanoni, Marco, Lombardi, Giovanni, Moretti, Matteo

“…The integration of vascular structures into in vitro cultured tissues provides realistic models of complex tissue-vascular interactions. Despite the incidence…”
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A miR-34a-SIRT6 axis in the squamous cell differentiation network by Lefort, Karine, Brooks, Yang, Ostano, Paola, Cario-André, Muriel, Calpini, Valérie, Guinea-Viniegra, Juan, Albinger-Hegyi, Andrea, Hoetzenecker, Wolfram, Kolfschoten, Ingrid, Wagner, Erwin F, Werner, Sabine, Dotto, Gian Paolo

“…Squamous cell carcinomas (SCCs) are highly heterogeneous tumours, resulting from deranged expression of genes involved in squamous cell differentiation. Here…”
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Survey on symptoms in patients receiving chemotherapy in an Italian department of oncology: a comparison between period prevalences by Crivelli, Francesca, Perfetti, Elisa, Sartorello, Barbara, Cantele, Valentina, Ostano, Paola, Ilardi, Francesco, Di Massimo, Dino Stefano, Clerico, Mario

“…Purpose The purpose of this study is to evaluate the prevalence over time of the measured side effects using a self-assessment questionnaire in normal clinical…”
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Gene Expression Signature Predictive of Neuroendocrine Transformation in Prostate Adenocarcinoma by Ostano, Paola, Mello-Grand, Maurizia, Sesia, Debora, Gregnanin, Ilaria, Peraldo-Neia, Caterina, Guana, Francesca, Jachetti, Elena, Farsetti, Antonella, Chiorino, Giovanna

“…Neuroendocrine prostate cancer (NEPC) can arise de novo, but much more commonly occurs as a consequence of a selective pressure from androgen deprivation…”
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Comprehensive Gene Expression Analysis to Identify Differences and Similarities between Sex- and Stage-Stratified Melanoma Samples by Chrysanthou, Eirini, Sehovic, Emir, Ostano, Paola, Chiorino, Giovanna

“…Overall lower incidence and better prognosis are observed in female melanoma patients compared to males. As sex and stage differences in the context of…”
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VEGF pathway inhibition potentiates PARP inhibitor efficacy in ovarian cancer independent of BRCA status by Bizzaro, Francesca, Fuso Nerini, Ilaria, Taylor, Molly A, Anastasia, Alessia, Russo, Massimo, Damia, Giovanna, Guffanti, Federica, Guana, Francesca, Ostano, Paola, Minoli, Lucia, Hattersley, Maureen M, Arnold, Stephanie, Ramos-Montoya, Antonio, Williamson, Stuart C, Galbiati, Alessandro, Urosevic, Jelena, Leo, Elisabetta, Cavallaro, Ugo, Ghilardi, Carmen, Barry, Simon T, Bani, Maria Rosa, Giavazzi, Raffaella

“…Poly ADP-ribose polymerase inhibitors (PARPi) have transformed ovarian cancer (OC) treatment, primarily for tumours deficient in homologous recombination…”
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Plasma microRNA ratios associated with breast cancer detection in a nested case–control study from a mammography screening cohort by Chiorino, Giovanna, Petracci, Elisabetta, Sehovic, Emir, Gregnanin, Ilaria, Camussi, Elisa, Mello-Grand, Maurizia, Ostano, Paola, Riggi, Emilia, Vergini, Viviana, Russo, Alessia, Berrino, Enrico, Ortale, Andrea, Garena, Francesca, Venesio, Tiziana, Gallo, Federica, Favettini, Elisabetta, Frigerio, Alfonso, Matullo, Giuseppe, Segnan, Nereo, Giordano, Livia

“…Mammographic breast cancer screening is effective in reducing breast cancer mortality. Nevertheless, several limitations are known. Therefore, developing an…”
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HSD17B7 gene in self‐renewal and oncogenicity of keratinocytes from Black versus White populations by Xu, Xiaoying, Tassone, Beatrice, Ostano, Paola, Katarkar, Atul, Proust, Tatiana, Joseph, Jean‐Marc, Riganti, Chiara, Chiorino, Giovanna, Kutalik, Zoltan, Lefort, Karine, Dotto, Gian Paolo

“…Human populations of Black African ancestry have a relatively high risk of aggressive cancer types, including keratinocyte‐derived squamous cell carcinomas…”
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Repurposing of the Antiepileptic Drug Levetiracetam to Restrain Neuroendocrine Prostate Cancer and Inhibit Mast Cell Support to Adenocarcinoma by Sulsenti, Roberta, Frossi, Barbara, Bongiovanni, Lucia, Cancila, Valeria, Ostano, Paola, Fischetti, Irene, Enriquez, Claudia, Guana, Francesca, Chiorino, Giovanna, Tripodo, Claudio, Pucillo, Carlo E, Colombo, Mario P, Jachetti, Elena

“…A relevant fraction of castration-resistant prostate cancers (CRPC) evolve into fatal neuroendocrine (NEPC) tumors in resistance to androgen deprivation and/or…”
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Cross-Talk between Myeloid-Derived Suppressor Cells and Mast Cells Mediates Tumor-Specific Immunosuppression in Prostate Cancer by Jachetti, Elena, Cancila, Valeria, Rigoni, Alice, Bongiovanni, Lucia, Cappetti, Barbara, Belmonte, Beatrice, Enriquez, Claudia, Casalini, Patrizia, Ostano, Paola, Frossi, Barbara, Sangaletti, Sabina, Chiodoni, Claudia, Chiorino, Giovanna, Pucillo, Carlo E, Tripodo, Claudio, Colombo, Mario P

“…Immunotherapy, including the use of checkpoint inhibitors, is a potent therapeutic approach for some cancers, but has limited success with prostate tumors, in…”
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