Search Results - "OSHIDA, Keiyu"

Chemical and Hormonal Effects on STAT5b-Dependent Sexual Dimorphism of the Liver Transcriptome by Oshida, Keiyu, Waxman, David J, Corton, J Christopher

“…The growth hormone (GH)-activated transcription factor signal transducer and activator of transcription 5b (STAT5b) is a key regulator of sexually dimorphic…”
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Plasma and urinary CP I and CP III concentrations in chimeric mice with human hepatocytes after rifampicin administration by Shishido, Yurina, Yoshida, Tomohiro, Oshida, Keiyu, Uchida, Masashi

“…The interest in transporter‐mediated drug interactions has been increasing in the field of drug development. In this study, we measured the plasma and urinary…”
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Disruption of STAT5b-Regulated Sexual Dimorphism of the Liver Transcriptome by Diverse Factors Is a Common Event by Oshida, Keiyu, Vasani, Naresh, Waxman, David J, Corton, J Christopher

“…Signal transducer and activator of transcription 5b (STAT5b) is a growth hormone (GH)-activated transcription factor and a master regulator of sexually…”
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Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor by Rooney, John, Oshida, Keiyu, Vasani, Naresh, Vallanat, Beena, Ryan, Natalia, Chorley, Brian N, Wang, Xuting, Bell, Douglas A, Wu, Kai C, Aleksunes, Lauren M, Klaassen, Curtis D, Kensler, Thomas W, Corton, J Christopher

“…The transcription factor Nrf2 (encoded by Nfe2l2) induces expression of numerous detoxifying and antioxidant genes in response to oxidative stress. The…”
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Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium by Oshida, Keiyu, Vasani, Naresh, Thomas, Russell S, Applegate, Dawn, Rosen, Mitch, Abbott, Barbara, Lau, Christopher, Guo, Grace, Aleksunes, Lauren M, Klaassen, Curtis, Corton, J Christopher

“…The nuclear receptor family member peroxisome proliferator-activated receptor α (PPARα) is activated by therapeutic hypolipidemic drugs and…”
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Spontaneous hemangioendothelial cell hyperplasia of the heart in a young ICR mouse by Tomikawa, Emi, Asaoka, Yoshiji, Togashi, Yuko, Mutsuga, Mayu, Imura, Naoko, Oshida, Keiyu

“…Spontaneous nonneoplastic proliferative lesions of the cardiac hemangioendothelium are extremely rare in humans and animals. Here, we describe a spontaneous…”
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Correction: Chemical and Hormonal Effects on STAT5b- Dependent Sexual Dimorphism of the Liver Transcriptome by Oshida, Keiyu, Waxman, David J, Corton, J Christopher

“…[This corrects the article DOI: 10.1371/journal.pone.0150284.]…”
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Toxicological effect of emodin in mouse testicular gene expression profile by Oshida, Keiyu, Hirakata, Mikito, Maeda, Akihisa, Miyoshi, Tomoya, Miyamoto, Yohei

“…ABSTRACT Emodin (1,3,8‐trihydroxy‐6‐methyl‐anthraquinone) is a herbal medicine extracted from the rhizomes of Rheum palmatum, and is known as an inhibitor of…”
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Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium by Oshida, Keiyu, Vasani, Naresh, Jones, Carlton, Moore, Tanya, Hester, Susan, Nesnow, Stephen, Auerbach, Scott, Geter, David R, Aleksunes, Lauren M, Thomas, Russell S, Applegate, Dawn, Klaassen, Curtis D, Corton, J Christopher

“…The nuclear receptor family member constitutive activated receptor (CAR) is activated by structurally diverse drugs and environmentally-relevant chemicals…”
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Identification of Transporters Involved in Beraprost Sodium Transport In Vitro by Oshida, Keiyu, Shimamura, Masahiro, Seya, Kazuhiro, Ando, Akihiro, Miyamoto, Yohei

“…Background and Objective Beraprost sodium (BPS) is a chemically stable and orally active prostacyclin analog that is used in the treatment of chronic arterial…”
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The Effects of a Selective CK2 Inhibitor on Anti-glomerular Basement Membrane Glomerulonephritis in Rats by Shi, Junfeng, Liu, Ning, Xiao, Ying, Takei, Yoshinori, Yasue, Misato, Suzuki, Yamato, Hou, Zengye, Ohno, Hiroaki, Yamada, Masateru, Fuchi, Nobuhiro, Oshida, Keiyu, Miyamoto, Yohei, Tsujimoto, Gozoh, Hirasawa, Akira

“…Protein kinase CK2 (“casein kinase II”) is a protein serine/threonine kinase that plays critical roles in biological processes such as cell growth, cell cycle…”
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Discrimination of genotoxic and non-genotoxic hepatocarcinogens by statistical analysis based on gene expression profiling in the mouse liver as determined by quantitative real-time PCR by Watanabe, Takashi, Suzuki, Takayoshi, Natsume, Masakatsu, Nakajima, Madoka, Narumi, Kazunori, Hamada, Shuichi, Sakuma, Tomohiro, Koeda, Akiko, Oshida, Keiyu, Miyamoto, Yohei, Maeda, Akihisa, Hirayama, Michiasa, Sanada, Hisakazu, Honda, Hiroshi, Ohyama, Wakako, Okada, Emiko, Fujiishi, Yohei, Sutou, Shizuyo, Tadakuma, Ayami, Ishikawa, Yasuyoshi, Kido, Mahoko, Minamiguchi, Rina, Hanahara, Izumi, Furihata, Chie

“…► We quantified gene expression in mouse liver by quantitative real-time PCR. ► We quantified 35 genes selected from our previous DNA microarray studies. ► We…”
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Immunosuppressive potential of bardoxolone methyl using a modified murine local lymph node assay (LLNA) by Kitsukawa, Mika, Tsuchiyama, Hiromi, Maeda, Akihisa, Oshida, Keiyu, Miyamoto, Yohei

“…2-Cyano-3, 12-dioxooleana-1, 9-dien-28-oic acid methyl ester (CDDO-Me; bardoxolone methyl) is one of the synthetic oleanane triterpenoids (SOs). It is known…”
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Evaluation of a liver micronucleus assay in young rats (III): A study using nine hepatotoxicants by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)–Mammalian Mutagenicity Study Group (MMS) by Takasawa, Hironao, Suzuki, Hiroshi, Ogawa, Izumi, Shimada, Yasushi, Kobayashi, Kazuo, Terashima, Yukari, Matsumoto, Hirotaka, Aruga, Chinami, Oshida, Keiyu, Ohta, Ryo, Imamura, Tadashi, Miyazaki, Atsushi, Kawabata, Masayoshi, Minowa, Shigenori, Hayashi, Makoto

“…We have been investigating a liver micronucleus assay to detect genotoxic chemicals using young rats for several years, and had established its advantages with…”
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Evaluation of a liver micronucleus assay in young rats (IV): A study using a double-dosing/single-sampling method by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)–Mammalian Mutagenicity Study Group (MMS) by Takasawa, Hironao, Suzuki, Hiroshi, Ogawa, Izumi, Shimada, Yasushi, Kobayashi, Kazuo, Terashima, Yukari, Matsumoto, Hirotaka, Oshida, Keiyu, Ohta, Ryo, Imamura, Tadashi, Miyazaki, Atsushi, Kawabata, Masayoshi, Minowa, Shigenori, Maeda, Akihisa, Hayashi, Makoto

“…A collaborative study was conducted to evaluate whether a liver micronucleus assay using four-week-old male F344 rats can be used to detect genotoxic rat…”
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An in vivo comet assay of multiple organs (liver, kidney and bone marrow) in mice treated with methyl methanesulfonate and acetaminophen accompanied by hematology and/or blood chemistry by Oshida, Keiyu, Iwanaga, Ema, Miyamoto-Kuramitsu, Keiko, Miyamoto, Yohei

“…The single cell gel electrophoresis (comet) assay is a simple and effective method for detecting DNA damage in cells with or without the capability of cell…”
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Identification of human cytochrome P450 enzymes involved in the metabolism of a novel к-opioid receptor agonist, nalfurafine hydrochloride by Ando, Akihiro, Oshida, Keiyu, Fukuyama, Shinichi, Watanabe, Ayano, Hashimoto, Hisashi, Miyamoto, Yohei

“…ABSTRACT Nalfurafine hydrochloride (TRK‐820) exhibits strong к‐opioid agonistic activity and is a new antipruritic agent for uremic pruritus. This study was…”
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Lysosomal trapping of 4-dimethylamino-1-{3-(1-methyl-1H-imidazole-2-yl)propanoyl}piperidine, a hydrophilic and weakly basic amine, in human aortic vascular smooth muscle cells by Takahashi, Kei, Morita, Yasuhiro, Udagawa, Shuji, Higashi, Eriko, Nakajima, Mayumi, Miyamoto, Yohei, Oshida, Keiyu

“…Some weakly basic compounds lead to cell death accompanied by cellular vacuolation. The novel analgesic agent,…”
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TXB-001, a newly-developed polymer-conjugated anthracycline: Significantly lower adverse effects in animal models of alopecia and hand-foot syndrome by Hirakata, Mikito, Tomikawa, Emi, Sakai, Chizuka, Uchida, Masashi, Okano, Tsubasa, Shimozono, Rieko, Kawai, Masakatsu, Itaba, Shoichi, Munakata, Lisa, Suzuki, Ryo, Oshida, Keiyu

“…Anthracycline anti-cancer drugs have been widely used in the treatment of several cancers; however, their use is limited by adverse effects (AEs). Alopecia is…”
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Chemical Activation of the Constitutive Androstane Receptor Leads to Activation of Oxidant-Induced Nrf2 by Rooney, John P, Oshida, Keiyu, Kumar, Ramiya, Baldwin, William S, Corton, J Christopher

“…Abstract Exposure to environmentally relevant chemicals that activate the xenobiotic receptors aryl hydrocarbon receptor (AhR), constitutive androstane…”
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