Search Results - "OSEROFF, A. R"

Photofrin photodynamic therapy can significantly deplete or preserve oxygenation in human basal cell carcinomas during treatment, depending on fluence rate by HENDERSON, B. W, BUSCH, T. M, GRECO, W. R, OSEROFF, A. R, VAUGHAN, L. A, FRAWLEY, N. P, BABICH, D, SOSA, T. A, ZOLLO, J. D, DEE, A. S, COOPER, M. T, BELLNIER, D. A

“…At high fluence rates in animal models, photodynamic therapy (PDT) can photochemically deplete ambient tumor oxygen through the generation of singlet oxygen,…”
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Comparison of Photodynamic Targets in a Carcinoma Cell Line and Its Mitochondrial DNA-Deficient Derivative by Morgan, J., Potter, W. R., Oseroff, A. R.

“…The relative contribution, to cell death, of photodynamic damage to respiratory proteins (known targets of photodynamic therapy with many photosensitizers) and…”
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Synthesis of β-Galactose-Conjugated Chlorins Derived by Enyne Metathesis as Galectin-Specific Photosensitizers for Photodynamic Therapy by Zheng, Gang, Graham, Andrew, Shibata, Masayuki, Missert, Joseph R, Oseroff, Allan R, Dougherty, Thomas J, Pandey, Ravindra K

“…A first report on the synthesis and biological evaluation of the β-galactose-conjugated purpurinimides (a class of chlorins containing a six-membered fused…”
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Photodynamic therapy for the treatment of extramammary Paget's disease by Shieh, S., Dee, A.S., Cheney, R.T., Frawley, N.P., Zeitouni, N.C., Oseroff, A.R.

“…Summary Background Surgical and ablative treatment modalities for extramammary Paget's disease (EMPD) have high recurrence rates and can be associated with…”
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Expression of the peripheral benzodiazepine receptor is decreased in skin cancers in comparison with normal skin by Morgan, J., Oseroff, A.R., Cheney, R.T.

“…Summary Background  The peripheral benzodiazepine receptor (PBR) is an 18‐kDa protein receptor mainly found on the outer mitochondrial membrane of cells. The…”
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Prognostic factors and evaluation of mycosis fungoides and Sézary syndrome by Toro, Jorge R., Stoll, Howard L., Stomper, Paul C., Oseroff, Allan R.

“…Background: Staging evaluations of patients with mycosis fungoides (MF) and Sézary syndrome (SS) are performed to individualize therapy and to predict…”
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Water-Soluble, Core-Modified Porphyrins as Novel, Longer-Wavelength-Absorbing Sensitizers for Photodynamic Therapy by Stilts, Corey E, Nelen, Marina I, Hilmey, David G, Davies, Sherry R, Gollnick, Sandra O, Oseroff, Allan R, Gibson, Scott L, Hilf, Russell, Detty, Michael R

“…Water-soluble, core-modified 5,10,15,20-tetrakis(4-sulfonatophenyl)-21,23-dithiaporphyrin (1) and…”
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Ceramic-Based Nanoparticles Entrapping Water-Insoluble Photosensitizing Anticancer Drugs:  A Novel Drug−Carrier System for Photodynamic Therapy by Roy, Indrajit, Ohulchanskyy, Tymish Y, Pudavar, Haridas E, Bergey, Earl J, Oseroff, Allan R, Morgan, Janet, Dougherty, Thomas J, Prasad, Paras N

“…A novel nanoparticle-based drug carrier for photodynamic therapy is reported which can provide stable aqueous dispersion of hydrophobic photosensitizers, yet…”
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Mitochondria-based photodynamic anti-cancer therapy by Morgan, Janet, Oseroff, Allan R

“…As photodynamic therapy (PDT) becomes established as a treatment for cancer, there is increasing interest in identifying critical mechanisms of cell killing…”
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A Selenopyrylium Photosensitizer for Photodynamic Therapy Related in Structure to the Antitumor Agent AA1 with Potent in Vivo Activity and No Long-Term Skin Photosensitization by Leonard, Kristi A, Hall, Jonathan P, Nelen, Marina I, Davies, Sherry R, Gollnick, Sandra O, Camacho, Sue, Oseroff, Allan R, Gibson, Scott L, Hilf, Russell, Detty, Michael R

“…Cationic chalcogenopyrylium dyes 5 were synthesized in six steps from p-aminophenylacetylene (9), have absorption maxima in methanol of 623, 654, and 680 nm…”
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Intramitochondrial Dyes Allow Selective in vitro Photolysis of Carcinoma Cells by Oseroff, A. R., Ohuoha, D., Ara, G., McAuliffe, D., Foley, J., Cincotta, L.

“…Carcinoma cell mitochondria preferentially accumulate and retain certain cationic dyes to a much greater extent than most normal cells. Thus, they can…”
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Synthesis and Evaluation of Chalcogenopyrylium Dyes as Potential Sensitizers for the Photodynamic Therapy of Cancer by Leonard, Kristi A, Nelen, Marina I, Simard, Todd P, Davies, Sherry R, Gollnick, Sandra O, Oseroff, Allan R, Gibson, Scott L, Hilf, Russell, Chen, Lan Bo, Detty, Michael R

“…A series of thiopyrylium (2), selenopyrylium (3), and telluropyrylium dyes (4) was prepared via the addition of Grignard reagents to either…”
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The role of transferrin receptor (CD71) in photodynamic therapy of activated and malignant lymphocytes using the heme precursor delta-aminolevulinic acid (ALA) by Rittenhouse-Diakun, K, Van Leengoed, H, Morgan, J, Hryhorenko, E, Paszkiewicz, G, Whitaker, J E, Oseroff, A R

“…Endogenously generated protoporphyrin IX (PpIX) from exogenous ALA can be an effective photosensitizer. PpIX accumulation is inversely dependent on available…”
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Antibody-Targeted Photolysis: Selective Photodestruction of Human T-Cell Leukemia Cells Using Monoclonal Antibody-Chlorin e6 Conjugates by Oseroff, Allan R., Ohuoha, Donald, Hasan, Tayyaba, Bommer, Jerry C., Yarmush, Martin L.

“…Selective in vitro photodestruction of HPB-ALL human T-cell leukemia cells was accomplished using the photosensitizer chlorin e6 coupled through dextran…”
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Photofrin photodynamic therapy for treatment of AIDS-related cutaneous Kaposi's sarcoma by BERNSTEIN, Z. P, WILSON, B. D, DOUGHERTY, T. J, OSEROFF, A. R, JONES, C. M, DOZIER, S. E, BROOKS, J. S. J, CHENEY, R, FOULKE, L, MANG, T. S, BELLNIER, D. A

“…Kaposi's sarcoma, the most common malignancy in AIDS patients, often presents with painful cutaneous lesions that are difficult to treat effectively despite a…”
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A Pulsed Electric Field Enhances Cutaneous Delivery of Methylene Blue in Excised Full-Thickness Porcine Skin by Johnson, Patricia G., Gallo, Stephen A., Hui, Sek Wen, Oseroff, Allan R.

“…We used electric pulses to permeabilize porcine stratum corneum and demonstrate enhanced epidermal transport of methylene blue, a water-soluble cationic dye…”
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Immune responses in patients with T-cell lymphoma treated with an anti-idiotype antibody mimicking a highly restricted T-cell antigen by Foon, K A, Oseroff, A R, Vaickus, L, Greenberg, S J, Russell, D, Bernstein, Z, Pincus, S, Köhler, H, Seon, B K, Tahaoglu, E

“…We generated an IgG1 murine monoclonal anti-idiotype antibody (Ab2) to a highly restricted T-cell antigen designated glycoprotein (gp) 37 that is found on…”
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Mitochondrial toxicity of cationic photosensitizers for photochemotherapy by MODICA-NAPOLITANO, J. S, JOYAL, J. L, ARA, G, OSEROFF, A. R, APRILLE, J. R

“…The triarylmethane derivative Victoria Blue-BO (VB-BO) and the chalcogenapyrylium (CP) dyes have potential for use in photochemotherapy, because they are taken…”
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Strategies for selective cancer photochemotherapy: antibody-targeted and selective carcinoma cell photolysis by Oseroff, A R, Ara, G, Ohuoha, D, Aprille, J, Bommer, J C, Yarmush, M L, Foley, J, Cincotta, L

“…A principle objective in chemotherapy is the development of modalities capable of selectively destroying malignant cells while sparing normal tissues. One new…”
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Antineoplastic activity, synergism, and antagonism of triarylalkylphosphonium salts and their combinations by Patel, J, Rideout, D, McCarthy, M R, Calogeropoulou, T, Wadwa, K S, Oseroff, A R

“…Previously, some of us demonstrated that monocationic phosphonium salt [4-(formylphenyl)methyl]triphenylphosphonium chloride (A) and…”
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