Search Results - "OSBORN, B. L"

A Phase 1 Study of PAmAb, a Fully Human Monoclonal Antibody against Bacillus anthracis Protective Antigen, in Healthy Volunteers by Subramanian, G. Mani, Cronin, Patrick W., Poley, Gerald, Weinstein, Andrea, Stoughton, Susan M., Zhong, John, Ou, Ying, Zmuda, Jonathan F., Osborn, Blaire L., Freimuth, William W.

“…Background. Inhibition of the binding of Bacillus anthracis protective antigen (PA) to its cellular receptor can abrogate the downstream toxin-mediated…”
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Pharmacokinetics and in vitro and in vivo anti-tumor response of an interleukin-2-human serum albumin fusion protein in mice by MELDER, Robert J, OSBORN, Blaire L, GRZEGORZEWSKI, Krzysztof J, GALLANT, Gilles, RICCOBENE, Todd, KANAKARAJ, Palanisamy, PING WEI, GUOXIAN CHEN, STOLOW, David, HALPERN, Wendy Green, MIGONE, Thi-Sau, QI WANG

“…Albuleukin fusion protein is a recombinant human interleukin-2 (rIL-2) genetically fused to recombinant human serum albumin (rHSA). The pharmacokinetics and…”
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Isotopic Differences in Human Growth Hormone Preparations by Abramson, Fred P, Osborn, Blaire L, Teffera, Yohannes

“…The 13C/12C isotope ratios have been measured for human pituitary growth hormone and three commercial growth hormone products in an attempt to differentiate…”
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Pharmacokinetic and metabolism studies using uniformly stable isotope labeled proteins with HPLC/CRIMS detection by Osborn, Blaire L., Abramson, Fred P.

“…We present a novel method for performing pharmacokinetic and metabolism studies on macromolecules that offers advantages over the existing techniques of…”
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Chloroquinoxaline sulfonamide : a sulfanilamide antitumor agent entering clinical trials by FISHERMAN, J. S, OSBORN, B. L, CHUN, H. G, PLOWMAN, J, SMITH, A. C, CHRISTIAN, M. C, ZAHARKO, D. S, SHOEMAKER, R. H

“…Chloroquinoxaline sulfonamide (CQS) has been developed to the clinical trial stage based on its activity in the Human Tumor Colony Forming Assay (HTCFA). In…”
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Production of uniformly stable isotope labelled proteins from mammalian cells by Osborn, Blaire L., Abramson, Fred P.

“…In order to implement a new strategy for determining the kinetics and metabolism of therapeutic proteins, we had to produce milligram quantities of a uniformly…”
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Stable-Isotope Dilution Studies of an Intact Protein Using High-Performance Liquid Chromatography/Chemical Reaction Interface Mass Spectrometry by Osborn, B.L., Abramson, F.P.

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Quantitation of human plasma levels of the anticancer agent carboxyamidotriazole by high-performance liquid chromatography by Holmes, K A, Chaffins, S, Osborn, B L, Liotta, L A, Kohn, E C

“…The predominant cause of death of cancer patients is growth and metastasis of their tumors. By targeting signal transduction pathways as sites of therapeutic…”
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Examining the origin of melatonin from a "natural" source by isotope ratio mass spectrometry with liquid chromatographic introduction by Chen, P. (George Washington University, Washington, DC.), Osborn, B.L, Abramson, F.P

“…The isotopic abundance of 13C often can be used to differentiate between natural and synthetic sources of a given material. These differences are small, and a…”
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Pharmacokinetic and pharmacodynamic studies of a human serum albumin-interferon-alpha fusion protein in cynomolgus monkeys by Osborn, Blaire L, Olsen, Henrik S, Nardelli, Bernardetta, Murray, James H, Zhou, Joe X H, Garcia, Andrew, Moody, Gordon, Zaritskaya, Liubov S, Sung, Cynthia

“…Interferon-alpha (IFN-alpha) is indicated for the treatment of certain viral infections including hepatitis B and C, and cancers such as melanoma. The short…”
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A phase 2 study to evaluate the antiviral activity, safety, and pharmacokinetics of recombinant human albumin-interferon alfa fusion protein in genotype 1 chronic hepatitis C patients by Bain, Vincent G., Kaita, Kelly D., Yoshida, Eric M., Swain, Mark G., Heathcote, E. Jenny, Neumann, Avidan U., Fiscella, Michele, Yu, Ren, Osborn, Blaire L., Cronin, Patrick W., Freimuth, William W., McHutchison, John G., Subramanian, G. Mani

“…Background/Aims : Recombinant human albumin-interferon alfa (alb-IFN) is a novel 85.7-kD recombinant protein consisting of interferon alfa-2b genetically fused…”
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Development of a Long-Acting Insulin Analog Using Albumin Fusion Technology by DUTTAROY, Alokesh, KANAKARAJ, Palanisamy, CROSSAN, Dan, BOCK, Jason, KAUFMAN, Thomas E, REAVEY, Peter, CAREY-BARBER, Melisa, KRISHNAN, Surekha R, GARCIA, Andy, MURPHY, Kelly, SISKIND, Jana K, MCLEAN, Malia A, OSBORN, Blaire L, CHENG, Susan, RUBEN, Steve, BIRSE, Charles E, BLONDEL, Olivier, SCHNEIDER, Helmut, PICKERAL, Oxana K, CHEN, Cecil, GUIYI ZHANG, KAITHAMANA, Shashi, SINGH, Mallika, SCHULINGKAMP, Robert

“…Development of a Long-Acting Insulin Analog Using Albumin Fusion Technology Alokesh Duttaroy , Palanisamy Kanakaraj , Blaire L. Osborn , Helmut Schneider ,…”
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Albutropin: a growth hormone–albumin fusion with improved pharmacokinetics and pharmacodynamics in rats and monkeys by Osborn, Blaire L, Sekut, Les, Corcoran, Marta, Poortman, Carol, Sturm, Bonnie, Chen, Guoxian, Mather, Donald, Lin, Hsiu Ling, Parry, Tom J

“…Growth hormone (GH) replacement therapy is used to treat GH deficiency. Treatment requires daily administration because of the short plasma t 1/2 of GH…”
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A Phase I/II study evaluating escalating doses of recombinant human albumin-interferon-alpha fusion protein in chronic hepatitis C patients who have failed previous interferon-alpha-based therapy by Balan, Vijayan, Nelson, David R, Sulkowski, Mark S, Everson, Gregory T, Lambiase, Louis R, Wiesner, Rusell H, Dickson, Rolland C, Post, Anthony B, Redfield, Robert R, Davis, Gary L, Neumann, Avidan U, Osborn, Blaire L, Freimuth, William W, Subramanian, G Mani

“…Albumin-interferon-alpha (IFN-alpha) is a novel 85.7-kDa recombinant protein consisting of IFN-alpha that is genetically fused to human serum albumin. In this…”
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