Search Results - "ORTON, Darren"

The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis by Astudillo, Luisana, Da Silva, Thiago G, Wang, Zhiqiang, Han, Xiaoqing, Jin, Ke, VanWye, Jeffrey, Zhu, Xiaoxia, Weaver, Kelly, Oashi, Taiji, Lopes, Pedro E M, Orton, Darren, Neitzel, Leif R, Lee, Ethan, Landgraf, Ralf, Robbins, David J, MacKerell, Jr, Alexander D, Capobianco, Anthony J

“…In many cancers, aberrant Notch activity has been demonstrated to play a role in the initiation and maintenance of the neoplastic phenotype and in cancer stem…”
Get full text

Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened by BIN LI, LIANG FEI, Dennis, ORTON, Darren, LU HAN, BAOLIN WANG, CAPOBIANCO, Anthony J, ETHAN LEE, ROBBINS, David J, FLAVENY, Colin A, DAHMANE, Nadia, BAUBET, Valérie, ZHIQIANG WANG, FENG BAI, PEI, Xin-Hai, RODRIGUEZ-BIANCO, Jezabel, BRIAN HANG

“…The Hedgehog (HH) signaling pathway represents an important class of emerging developmental signaling pathways that play critical roles in the genesis of a…”
Get full text

Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis by Li, Bin, Flaveny, Colin A, Giambelli, Camilla, Fei, Dennis Liang, Han, Lu, Hang, Brian I, Bai, Feng, Pei, Xin-Hai, Nose, Vania, Burlingame, Oname, Capobianco, Anthony J, Orton, Darren, Lee, Ethan, Robbins, David J

“…Mutations in the WNT-pathway regulator ADENOMATOUS POLYPOSIS COLI (APC) promote aberrant activation of the WNT pathway that is responsible for APC-associated…”
Get full text

An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission by Shirey, Jana K, Xiang, Zixiu, Orton, Darren, Brady, Ashley E, Johnson, Kari A, Williams, Richard, Ayala, Jennifer E, Rodriguez, Alice L, Wess, Jürgen, Weaver, David, Niswender, Colleen M, Conn, P Jeffrey

“…Muscarinic acetylcholine receptors (mAChRs) provide viable targets for the treatment of multiple central nervous system disorders. We have used cheminformatics…”
Get full text

Targeting the Wnt pathway in synovial sarcoma models by Barham, Whitney, Frump, Andrea L, Sherrill, Taylor P, Garcia, Christina B, Saito-Diaz, Kenyi, VanSaun, Michael N, Fingleton, Barbara, Gleaves, Linda, Orton, Darren, Capecchi, Mario R, Blackwell, Timothy S, Lee, Ethan, Yull, Fiona, Eid, Josiane E

“…Synovial sarcoma is an aggressive soft-tissue malignancy of children and young adults, with no effective systemic therapies. Its specific oncogene, SYT-SSX…”
Get more information

The antihelmintic drug pyrvinium pamoate targets aggressive breast cancer by Xu, Wei, Lacerda, Lara, Debeb, Bisrat G, Atkinson, Rachel L, Solley, Travis N, Li, Li, Orton, Darren, McMurray, John S, Hang, Brian I, Lee, Ethan, Klopp, Ann H, Ueno, Naoto T, Reuben, James M, Krishnamurthy, Savitri, Woodward, Wendy A

“…WNT signaling plays a key role in the self-renewal of tumor initiation cells (TICs). In this study, we used pyrvinium pamoate (PP), an FDA-approved…”
Get full text

SU11248 (Sunitinib) Sensitizes Pancreatic Cancer to the Cytotoxic Effects of Ionizing Radiation by Cuneo, Kyle C., M.D, Geng, Ling, M.D, Fu, Allie, B.S, Orton, Darren, Ph.D, Hallahan, Dennis E., M.D, Chakravarthy, Anuradha Bapsi, M.D

“…Purpose SU11248 (sunitinib) is a small-molecule tyrosine kinase inhibitor which targets VEGFR and PDGFR isoforms. In the present study, the effects of SU11248…”
Get full text

Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity by Marlo, Joy E, Niswender, Colleen M, Days, Emily L, Bridges, Thomas M, Xiang, Yun, Rodriguez, Alice L, Shirey, Jana K, Brady, Ashley E, Nalywajko, Tasha, Luo, Qingwei, Austin, Cheryl A, Williams, Michael Baxter, Kim, Kwangho, Williams, Richard, Orton, Darren, Brown, H Alex, Lindsley, Craig W, Weaver, C David, Conn, P Jeffrey

“…Activators of M(1) muscarinic acetylcholine receptors (mAChRs) may provide novel treatments for schizophrenia and Alzheimer's disease. Unfortunately, the…”
Get more information

Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells by Alvarez-Trotta, Annamil, Guerrant, William, Astudillo, Luisana, Lahiry, Mohini, Diluvio, Giulia, Shersher, Elena, Kaneku, Hugo, Robbins, David J, Orton, Darren, Capobianco, Anthony J

“…In many human cancers, deregulation of the Notch pathway has been shown to play a role in the initiation and maintenance of the neoplastic phenotype. Aberrant…”
Get full text

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α by Lee, Ethan, Thorne, Curtis A, Hanson, Alison J, Schneider, Judsen, Tahinci, Emilios, Orton, Darren, Cselenyi, Christopher S, Jernigan, Kristin K, Meyers, Kelly C, Hang, Brian I, Waterson, Alex G, Kim, Kwangho, Melancon, Bruce, Ghidu, Victor P, Sulikowski, Gary A, LaFleur, Bonnie, Salic, Adrian, Lee, Laura A, Miller, David M

“…A Xenopus laevis two-reporter screen identifies the antihelminthic drug pyrvinium as an inhibitor of the Wnt/β-catenin signaling pathway that works by…”
Get full text

A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma by Rodriguez-Blanco, Jezabel, Li, Bin, Long, Jun, Shen, Chen, Yang, Fan, Orton, Darren, Collins, Sara, Kasahara, Noriyuki, Ayad, Nagi G, McCrea, Heather J, Roussel, Martine F, Weiss, William A, Capobianco, Anthony J, Robbins, David J

“…Although most children with medulloblastoma are cured of their disease, Sonic Hedgehog (SHH) subgroup medulloblastoma driven by mutations is essentially…”
Get full text

Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors by Li, Bin, Orton, Darren, Neitzel, Leif R, Astudillo, Luisana, Shen, Chen, Long, Jun, Chen, Xi, Kirkbride, Kellye C, Doundoulakis, Thomas, Guerra, Marcy L, Zaias, Julia, Fei, Dennis Liang, Rodriguez-Blanco, Jezabel, Thorne, Curtis, Wang, Zhiqiang, Jin, Ke, Nguyen, Dao M, Sands, Laurence R, Marchetti, Floriano, Abreu, Maria T, Cobb, Melanie H, Capobianco, Anthony J, Lee, Ethan, Robbins, David J

“…Constitutive WNT activity drives the growth of various human tumors, including nearly all colorectal cancers (CRCs). Despite this prominence in cancer, no WNT…”
Get more information

An allosteric potentiator of M 4 mAChR modulates hippocampal synaptic transmission by Conn, P Jeffrey, Shirey, Jana K, Xiang, Zixiu, Orton, Darren, Brady, Ashley E, Johnson, Kari A, Williams, Richard, Ayala, Jennifer E, Rodriguez, Alice L, Wess, Jürgen, Weaver, David, Niswender, Colleen M

Get full text

Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7 by Niswender, Colleen M, Johnson, Kari A, Miller, Nicole R, Ayala, Jennifer E, Luo, Qingwei, Williams, Richard, Saleh, Samir, Orton, Darren, Weaver, C David, Conn, P Jeffrey

“…Phenotypic studies of mice lacking metabotropic glutamate receptor subtype 7 (mGluR7) suggest that antagonists of this receptor may be promising for the…”
Get more information

Biology Contribution: SU11248 (Sunitinib) Sensitizes Pancreatic Cancer to the Cytotoxic Effects of Ionizing Radiation by Cuneo, Kyle C, Geng, Ling, Fu, Allie, Orton, Darren, Hallahan, Dennis E, Chakravarthy, Anuradha Bapsi

“…Purpose: SU11248 (sunitinib) is a small-molecule tyrosine kinase inhibitor which targets VEGFR and PDGFR isoforms. In the present study, the effects of SU11248…”
Get full text

Asymmetric Synthesis of the Putative Structure of (−)-Oryzoxymycin by Bunnage, Mark E, Ganesh, Thota, Masesane, Ishmael B, Orton, Darren, Steel, Patrick G

“…A short asymmetric synthesis of (2‘S,5R,6R)-2‘-[6-amino-5-hydroxy-1,3-cyclohexadiene-1-carbonyloxy]propionic acid, the enantiomer of the reported structure of…”
Get full text

A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopus egg extracts by Thorne, Curtis A, Lafleur, Bonnie, Lewis, Michelle, Hanson, Alison J, Jernigan, Kristin K, Weaver, David C, Huppert, Kari A, Chen, Tony W, Wichaidit, Chonlarat, Cselenyi, Christopher S, Tahinci, Emilios, Meyers, Kelly C, Waskow, Emily, Orton, Darren, Salic, Adrian, Lee, Laura A, Robbins, David J, Huppert, Stacey S, Lee, Ethan

“…Misregulation of the Wnt pathway has been shown to be responsible for a variety of human diseases, most notably cancers. Screens for inhibitors of this pathway…”
Get more information

Structure–activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties by Corte, James R., Fang, Tianan, Pinto, Donald J.P., Han, Wei, Hu, Zilun, Jiang, Xiang-Jun, Li, Yun-Long, Gauuan, Jolicia F., Hadden, Mark, Orton, Darren, Rendina, Alan R., Luettgen, Joseph M., Wong, Pancras C., He, Kan, Morin, Paul E., Chang, Chong-Hwan, Cheney, Daniel L., Knabb, Robert M., Wexler, Ruth R., Lam, Patrick Y.S.

“…Introduction of the phenyl piperidinone and phenyl pyridinone P4 moieties in the anthranilamide scaffold led to potent, selective, and orally bioavailable…”
Get full text

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1[alpha] by Thorne, Curtis A, Hanson, Alison J, Schneider, Judsen, Tahinci, Emilios, Orton, Darren, Cselenyi, Christopher S, Jernigan, Kristin K, Meyers, Kelly C, Hang, Brian I, Waterson, Alex G, Kim, Kwangho, Melancon, Bruce, Ghidu, Victor P, Sulikowski, Gary A, Lafleur, Bonnie, Salic, Adrian, Lee, Laura A, Miller, David M, Lee, Ethan

“…Wnt/b-catenin signaling is critically involved in metazoan development, stem cell maintenance and human disease. Using Xenopus laevis egg extract to screen for…”
Get full text

The Antihelmintic Drug Pyrvinium Pamoate Targets Aggressive Breast Cancer: e71508 by Xu, Wei, Lacerda, Lara, Debeb, Bisrat G, Atkinson, Rachel L, Solley, Travis N, Li, Li, Orton, Darren, McMurray, John S, Hang, Brian I, Lee, Ethan

“…WNT signaling plays a key role in the self-renewal of tumor initiation cells (TICs). In this study, we used pyrvinium pamoate (PP), an FDA-approved…”
Get full text