Search Results - "ORTH, Michael"

Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches by Orth, Michael, Metzger, Philipp, Gerum, Sabine, Mayerle, Julia, Schneider, Günter, Belka, Claus, Schnurr, Maximilian, Lauber, Kirsten

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence. Late detection and a particularly aggressive…”
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Accelerated expansion of pathogenic mitochondrial DNA heteroplasmies in Huntington’s disease by Wang, Yiqin, Guo, Xiaoxian, Ye, Kaixiong, Orth, Michael, Gu, Zhenglong

“…Mitochondrial dysfunction is found in the brain and peripheral tissues of patients diagnosed with Huntington’s disease (HD), an irreversible neurodegenerative…”
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Diagnostic contribution and therapeutic perspectives of transcranial magnetic stimulation in dementia by Di Lazzaro, Vincenzo, Bella, Rita, Benussi, Alberto, Bologna, Matteo, Borroni, Barbara, Capone, Fioravante, Chen, Kai-Hsiang S., Chen, Robert, Chistyakov, Andrei V., Classen, Joseph, Kiernan, Matthew C., Koch, Giacomo, Lanza, Giuseppe, Lefaucheur, Jean-Pascal, Matsumoto, Hideyuki, Nguyen, Jean-Paul, Orth, Michael, Pascual-Leone, Alvaro, Rektorova, Irena, Simko, Patrik, Taylor, John-Paul, Tremblay, Sara, Ugawa, Yoshikazu, Dubbioso, Raffaele, Ranieri, Federico

“…•This review presents the contribution of TMS to the management of dementia.•TMS can be used as a biomarker of the excitability and function of cerebral cortex…”
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Practice improves older adults’ attentional control and prospective memory more than HD-tDCS: a randomized controlled trial by Schmidt, Nadine, Menéndez-Granda, Marta, Münger, Ronya, Hatzipanayioti, Adamantini, Kliegel, Matthias, Orth, Michael, Peter, Jessica

“…Frontal and parietal brain regions are involved in attentional control and prospective memory. It is debated, however, whether increased or decreased activity…”
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Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells by Krombach, Julia, Hennel, Roman, Brix, Nikko, Orth, Michael, Schoetz, Ulrike, Ernst, Anne, Schuster, Jessica, Zuchtriegel, Gabriele, Reichel, Christoph A., Bierschenk, Susanne, Sperandio, Markus, Vogl, Thomas, Unkel, Steffen, Belka, Claus, Lauber, Kirsten

“…The major goal of radiotherapy is the induction of tumor cell death. Additionally, radiotherapy can function as in situ cancer vaccination by exposing tumor…”
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A modifier of Huntington's disease onset at the MLH1 locus by Lee, Jong-Min, Chao, Michael J, Harold, Denise, Abu Elneel, Kawther, Gillis, Tammy, Holmans, Peter, Jones, Lesley, Orth, Michael, Myers, Richard H, Kwak, Seung, Wheeler, Vanessa C, MacDonald, Marcy E, Gusella, James F

“…Huntington's disease (HD) is a dominantly inherited neurodegenerative disease caused by an expanded CAG repeat in HTT. Many clinical characteristics of HD such…”
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The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment by Peter, Jessica, Mayer, Isabella, Kammer, Thomas, Minkova, Lora, Lahr, Jacob, Klöppel, Stefan, Grothe, Michel J., Orth, Michael

“…We assessed the structure–function relationship of the human cholinergic system and hypothesized that structural measures are associated with short-latency…”
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Abnormal molecular signatures of inflammation, energy metabolism, and vesicle biology in human Huntington disease peripheral tissues by Neueder, Andreas, Kojer, Kerstin, Hering, Tanja, Lavery, Daniel J, Chen, Jian, Birth, Nathalie, Hallitsch, Jaqueline, Trautmann, Sonja, Parker, Jennifer, Flower, Michael, Sethi, Huma, Haider, Salman, Lee, Jong-Min, Tabrizi, Sarah J, Orth, Michael

“…A major challenge in neurodegenerative diseases concerns identifying biological disease signatures that track with disease progression or respond to an…”
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Tumor-Specific Delivery of 5-Fluorouracil–Incorporated Epidermal Growth Factor Receptor–Targeted Aptamers as an Efficient Treatment in Pancreatic Ductal Adenocarcinoma Models by Mahajan, Ujjwal M., Li, Qi, Alnatsha, Ahmed, Maas, Jessica, Orth, Michael, Maier, Sebastian Hubertus, Peterhansl, Julian, Regel, Ivonne, Sendler, Matthias, Wagh, Preshit R., Mishra, Neha, Xue, Yonggan, Allawadhi, Prince, Beyer, Georg, Kühn, Jens-Peter, Marshall, Thomas, Appel, Bettina, Lämmerhirt, Felix, Belka, Claus, Müller, Sabine, Weiss, Frank-Ulrich, Lauber, Kirsten, Lerch, Markus M., Mayerle, Julia

“…Fluoropyrimidine c (5-fluorouracil [5FU]) increasingly represents the chemotherapeutic backbone for neoadjuvant, adjuvant, and palliative treatment of…”
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The effect of loss incentives on prospective memory in healthy older adults: study protocol of a randomized controlled trial using ultra-high field fMRI by Menéndez-Granda, Marta, Schmidt, Nadine, Orth, Michael, Klink, Katharina, Horn, Sebastian, Kliegel, Matthias, Peter, Jessica

“…Prospective memory is important for our health and independence but declines with age. Hence, interventions to enhance prospective memory, for example by…”
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Early senescence and production of senescence-associated cytokines are major determinants of radioresistance in head-and-neck squamous cell carcinoma by Schoetz, Ulrike, Klein, Diana, Hess, Julia, Shnayien, Seyd, Spoerl, Steffen, Orth, Michael, Mutlu, Samet, Hennel, Roman, Sieber, Anja, Ganswindt, Ute, Luka, Benedikt, Thomsen, Andreas R., Unger, Kristian, Jendrossek, Verena, Zitzelsberger, Horst, Blüthgen, Nils, Belka, Claus, Unkel, Steffen, Klinger, Bertram, Lauber, Kirsten

“…Resistance against radio(chemo)therapy-induced cell death is a major determinant of oncological treatment failure and remains a perpetual clinical challenge…”
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Motor cortex synchronization influences the rhythm of motor performance in premanifest huntington's disease by Casula, Elias P., Mayer, Isabella M. S., Desikan, Mahalekshmi, Tabrizi, Sarah J., Rothwell, John C., Orth, Michael

“…ABSTRACT Background: In Huntington's disease there is evidence of structural damage in the motor system, but it is still unclear how to link this to the…”
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The risk of re-identification versus the need to identify individuals in rare disease research by Hansson, Mats G, Lochmüller, Hanns, Riess, Olaf, Schaefer, Franz, Orth, Michael, Rubinstein, Yaffa, Molster, Caron, Dawkins, Hugh, Taruscio, Domenica, Posada, Manuel, Woods, Simon

“…There is a growing concern in the ethics literature and among policy makers that de-identification or coding of personal data and biospecimens is not…”
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HSP90 inhibition as a means of radiosensitizing resistant, aggressive soft tissue sarcomas by Ernst, Anne, Anders, Heike, Kapfhammer, Heidi, Orth, Michael, Hennel, Roman, Seidl, Karin, Winssinger, Nicolas, Belka, Claus, Unkel, Steffen, Lauber, Kirsten

“…Highlights • Intrinsic radioresistance of soft tissue sarcoma cell lines as measured by clonogenic survival varies substantially. • Scores of radioresistance…”
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Dying cell clearance and its impact on the outcome of tumor radiotherapy by Lauber, Kirsten, Ernst, Anne, Orth, Michael, Herrmann, Martin, Belka, Claus

“…The induction of tumor cell death is one of the major goals of radiotherapy and has been considered to be the central determinant of its therapeutic outcome…”
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Dynamics of cell-free tumor DNA correlate with early MRI response during chemoradiotherapy in rectal cancer by Clasen, Kerstin, Gani, Cihan, Schuetz, Leon, Clasen, Stephan, Ballin, Nadja, Bonzheim, Irina, Orth, Michael, Ossowski, Stephan, Riess, Olaf, Niyazi, Maximilian, Schroeder, Christopher, Kelemen, Olga

“…Abstract Background In locally advanced rectal cancer, the prediction of tumor response during and after neoadjuvant treatment remains challenging. In terms of…”
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Prognostic value of PD-L1 expression on tumor cells combined with CD8+ TIL density in patients with locally advanced non-small cell lung cancer treated with concurrent chemoradiotherapy by Gennen, Kathrin, Käsmann, Lukas, Taugner, Julian, Eze, Chukwuka, Karin, Monika, Roengvoraphoj, Olarn, Neumann, Jens, Tufman, Amanda, Orth, Michael, Reu, Simone, Belka, Claus, Manapov, Farkhad

“…mmune checkpoint inhibition (CPI) has an increasing impact in the multimodal treatment of locally advanced non-small cell lung cancer (LA-NSCLC). Increasing…”
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In vitro evaluation of simulated stereotactic radiotherapy for wet age-related macular degeneration on three different cell lines by Vounotrypidis, Efstathios, Hillenmayer, Anna, Wertheimer, Christian M., Athanasiou, Alexis, Siedlecki, Jakob, Orth, Michael, Ohlmann, Andreas, Priglinger, Siegfried G., Wolf, Armin

“…Low energy stereotactic radiotherapy has been proposed for the treatment of neovascular age related macular degeneration. We investigated the in vitro effect…”
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Increased Bone Adiposity and Peroxisomal Proliferator-Activated Receptor-γ2 Expression in Type I Diabetic Mice by Botolin, Sergiu, Faugere, Marie-Claude, Malluche, Hartmut, Orth, Michael, Meyer, Ron, McCabe, Laura R

“…Decreased bone mass, osteoporosis, and increased fracture rates are common skeletal complications in patients with insulin-dependent diabetes mellitus (IDDM;…”
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Systematic in vitro analysis of therapy resistance in glioblastoma cell lines by integration of clonogenic survival data with multi-level molecular data by Schnöller, Leon Emanuel, Piehlmaier, Daniel, Weber, Peter, Brix, Nikko, Fleischmann, Daniel Felix, Nieto, Alexander Edward, Selmansberger, Martin, Heider, Theresa, Hess, Julia, Niyazi, Maximilian, Belka, Claus, Lauber, Kirsten, Unger, Kristian, Orth, Michael

“…Despite intensive basic scientific, translational, and clinical efforts in the last decades, glioblastoma remains a devastating disease with a highly dismal…”
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