Search Results - "ORSINI, Paolo"

Present Scenario and Future Landscape of Payloads for ADCs: Focus on DNA-Interacting Agents by Valsasina, Barbara, Orsini, Paolo, Terenghi, Chiara, Ocana, Alberto

“…ADCs have emerged as a promising class of therapeutics, combining the targeting specificity of monoclonal antibodies with the cytotoxic potency of…”
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Discovery of Entrectinib: A New 3‑Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c‑ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor by Menichincheri, Maria, Ardini, Elena, Magnaghi, Paola, Avanzi, Nilla, Banfi, Patrizia, Bossi, Roberto, Buffa, Laura, Canevari, Giulia, Ceriani, Lucio, Colombo, Maristella, Corti, Luca, Donati, Daniele, Fasolini, Marina, Felder, Eduard, Fiorelli, Claudio, Fiorentini, Francesco, Galvani, Arturo, Isacchi, Antonella, Borgia, Andrea Lombardi, Marchionni, Chiara, Nesi, Marcella, Orrenius, Christian, Panzeri, Achille, Pesenti, Enrico, Rusconi, Luisa, Saccardo, Maria Beatrice, Vanotti, Ermes, Perrone, Ettore, Orsini, Paolo

“…Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase responsible for the development of different tumor types. Despite the remarkable clinical…”
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Two-Photon Polymerization of Sub-micrometric Patterned Surfaces: Investigation of Cell-Substrate Interactions and Improved Differentiation of Neuron-like Cells by Marino, Attilio, Ciofani, Gianni, Filippeschi, Carlo, Pellegrino, Mario, Pellegrini, Monica, Orsini, Paolo, Pasqualetti, Massimo, Mattoli, Virgilio, Mazzolai, Barbara

“…Direct Laser Writing (DLW) is an innovative tool that allows the photofabrication of high resolution 3D structures, which can be successfully exploited for the…”
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An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma by Sano, Renata, Krytska, Kateryna, Larmour, Colleen E, Raman, Pichai, Martinez, Daniel, Ligon, Gwenda F, Lillquist, Jay S, Cucchi, Ulisse, Orsini, Paolo, Rizzi, Simona, Pawel, Bruce R, Alvarado, Diego, Mossé, Yael P

“…Enthusiasm for the use of antibody-drug conjugates (ADCs) in cancer therapy has risen over the past few years. The success of this therapeutic approach relies…”
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Discovery of 2‑[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro‑1H‑isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP‑1 Inhibitor for Cancer Therapy by Papeo, Gianluca, Posteri, Helena, Borghi, Daniela, Busel, Alina A., Caprera, Francesco, Casale, Elena, Ciomei, Marina, Cirla, Alessandra, Corti, Emiliana, D’Anello, Matteo, Fasolini, Marina, Forte, Barbara, Galvani, Arturo, Isacchi, Antonella, Khvat, Alexander, Krasavin, Mikhail Y., Lupi, Rosita, Orsini, Paolo, Perego, Rita, Pesenti, Enrico, Pezzetta, Daniele, Rainoldi, Sonia, Riccardi-Sirtori, Federico, Scolaro, Alessandra, Sola, Francesco, Zuccotto, Fabio, Felder, Eduard R., Donati, Daniele, Montagnoli, Alessia

“…The nuclear protein poly­(ADP-ribose) polymerase-1 (PARP-1) has a well-established role in the signaling and repair of DNA and is a prominent target in…”
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Effects of a short period of postural training on postural stability and vestibulospinal reflexes by Grasso, Claudia, Barresi, Massimo, Tramonti Fantozzi, Maria Paola, Lazzerini, Francesco, Bruschini, Luca, Berrettini, Stefano, Andre, Paolo, Dolciotti, Cristina, De Cicco, Vincenzo, De Cicco, Davide, d'Ascanio, Paola, Orsini, Paolo, Montanari, Francesco, Faraguna, Ugo, Manzoni, Diego

“…The effects of postural training on postural stability and vestibulospinal reflexes (VSRs) were investigated in normal subjects. A period (23 minutes) of…”
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Pupil Data Upon Stimulation by Auditory Stimuli by La Rosa, Davide, Bruschini, Luca, Tramonti Fantozzi, Maria Paola, Orsini, Paolo, Milazzo, Mario, Crivello, Antonino

“…Evaluating hearing in newborns and uncooperative patients can pose a considerable challenge. One potential solution might be to employ the Pupil Dilation…”
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EV20/NMS-P945, a Novel Thienoindole Based Antibody-Drug Conjugate Targeting HER-3 for Solid Tumors by Capone, Emily, Lattanzio, Rossano, Gasparri, Fabio, Orsini, Paolo, Rossi, Cosmo, Iacobelli, Valentina, De Laurenzi, Vincenzo, Natali, Pier Giorgio, Valsasina, Barbara, Iacobelli, Stefano, Sala, Gianluca

“…HER-3 is becoming an attractive target for antibody-drug conjugate (ADC)-based therapy. Indeed, this receptor and its ligands are found to be overexpressed in…”
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Measuring the elastic properties of living cells through the analysis of current–displacement curves in scanning ion conductance microscopy by Pellegrino, Mario, Pellegrini, Monica, Orsini, Paolo, Tognoni, Elisabetta, Ascoli, Cesare, Baschieri, Paolo, Dinelli, Franco

“…Knowledge of mechanical properties of living cells is essential to understand their physiological and pathological conditions. To measure local cellular…”
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Weak hydrostatic forces in far-scanning ion conductance microscopy used to guide neuronal growth cones by Pellegrino, Mario, Orsini, Paolo, Pellegrini, Monica, Baschieri, Paolo, Dinelli, Franco, Petracchi, Donatella, Tognoni, Elisabetta, Ascoli, Cesare

“…▶ The electrolyte level in SICM pipette determines the presence of hydrostatic forces. ▶ We measured these forces by means of a combined system AFM–SICM. ▶…”
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Cdc7 Kinase Inhibitors: 5-Heteroaryl-3-Carboxamido-2-Aryl Pyrroles as Potential Antitumor Agents. 1. Lead Finding by Menichincheri, Maria, Albanese, Clara, Alli, Cristina, Ballinari, Dario, Bargiotti, Alberto, Caldarelli, Marina, Ciavolella, Antonella, Cirla, Alessandra, Colombo, Maristella, Colotta, Francesco, Croci, Valter, D’Alessio, Roberto, D’Anello, Matteo, Ermoli, Antonella, Fiorentini, Francesco, Forte, Barbara, Galvani, Arturo, Giordano, Patrizia, Isacchi, Antonella, Martina, Katia, Molinari, Antonio, Moll, Jürgen K, Montagnoli, Alessia, Orsini, Paolo, Orzi, Fabrizio, Pesenti, Enrico, Pillan, Antonio, Roletto, Fulvia, Scolaro, Alessandra, Tatò, Marco, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Vianello, Paola, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes

“…Cdc7 serine/threonine kinase is a key regulator of DNA synthesis in eukaryotic organisms. Cdc7 inhibition through siRNA or prototype small molecules causes p53…”
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Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships by Vanotti, Ermes, Amici, Raffaella, Bargiotti, Alberto, Berthelsen, Jens, Bosotti, Roberta, Ciavolella, Antonella, Cirla, Alessandra, Cristiani, Cinzia, D’Alessio, Roberto, Forte, Barbara, Isacchi, Antonella, Martina, Katia, Menichincheri, Maria, Molinari, Antonio, Montagnoli, Alessia, Orsini, Paolo, Pillan, Antonio, Roletto, Fulvia, Scolaro, Alessandra, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Volpi, Daniele, Santocanale, Corrado

“…Cdc7 kinase is an essential protein that promotes DNA replication in eukaryotic organisms. Genetic evidence indicates that Cdc7 inhibition can cause selective…”
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Optimization of 6,6-dimethyl pyrrolo[3,4- c]pyrazoles: Identification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing by Brasca, Maria Gabriella, Albanese, Clara, Alzani, Rachele, Amici, Raffaella, Avanzi, Nilla, Ballinari, Dario, Bischoff, James, Borghi, Daniela, Casale, Elena, Croci, Valter, Fiorentini, Francesco, Isacchi, Antonella, Mercurio, Ciro, Nesi, Marcella, Orsini, Paolo, Pastori, Wilma, Pesenti, Enrico, Pevarello, Paolo, Roussel, Patrick, Varasi, Mario, Volpi, Daniele, Vulpetti, Anna, Ciomei, Marina

“…We describe the synthesis of compounds with interesting biochemical and cellular characteristics. Optimization of the physico-chemical properties led to the…”
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First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery by Menichincheri, Maria, Bargiotti, Alberto, Berthelsen, Jens, Bertrand, Jay A, Bossi, Roberto, Ciavolella, Antonella, Cirla, Alessandra, Cristiani, Cinzia, Croci, Valter, D’Alessio, Roberto, Fasolini, Marina, Fiorentini, Francesco, Forte, Barbara, Isacchi, Antonella, Martina, Katia, Molinari, Antonio, Montagnoli, Alessia, Orsini, Paolo, Orzi, Fabrizio, Pesenti, Enrico, Pezzetta, Daniele, Pillan, Antonio, Poggesi, Italo, Roletto, Fulvia, Scolaro, Alessandra, Tatò, Marco, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes

“…Cdc7 kinase is a key regulator of the S-phase of the cell cycle, known to promote the activation of DNA replication origins in eukaryotic organisms. Cdc7…”
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3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 1. Lead Finding by Pevarello, Paolo, Brasca, Maria Gabriella, Amici, Raffaella, Orsini, Paolo, Traquandi, Gabriella, Corti, Luca, Piutti, Claudia, Sansonna, Pietro, Villa, Manuela, Pierce, Betsy S, Pulici, Maurizio, Giordano, Patrizia, Martina, Katia, Fritzen, Edward L, Nugent, Richard A, Casale, Elena, Cameron, Alexander, Ciomei, Marina, Roletto, Fulvia, Isacchi, Antonella, Fogliatto, GianPaolo, Pesenti, Enrico, Pastori, Wilma, Marsiglio, Aurelio, Leach, Karen L, Clare, Paula M, Fiorentini, Francesco, Varasi, Mario, Vulpetti, Anna, Warpehoski, Martha A

“…Abnormal proliferation mediated by disruption of the normal cell cycle mechanisms is a hallmark of virtually all cancer cells. Compounds targeting complexes…”
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3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 2. Lead Optimization by Pevarello, Paolo, Brasca, Maria Gabriella, Orsini, Paolo, Traquandi, Gabriella, Longo, Antonio, Nesi, Marcella, Orzi, Fabrizio, Piutti, Claudia, Sansonna, Pietro, Varasi, Mario, Cameron, Alexander, Vulpetti, Anna, Roletto, Fulvia, Alzani, Rachele, Ciomei, Marina, Albanese, Clara, Pastori, Wilma, Marsiglio, Aurelio, Pesenti, Enrico, Fiorentini, Francesco, Bischoff, Jim R, Mercurio, Ciro

“…Inhibitors of cyclin-dependent kinases (CDK) such as CDK2/cyclin A−E are currently undergoing clinical trials to verify their potential as new anticancer…”
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Poly(ADP-ribose) polymerase inhibition in cancer therapy: are we close to maturity? by Papeo, Gianluca, Forte, Barbara, Orsini, Paolo, Perrera, Claudia, Posteri, Helena, Scolaro, Alessandra, Montagnoli, Alessia

“…During the last few years an increasing number of poly(ADP-ribose) polymerase (PARP) inhibitors have been appearing in the context of cancer therapy. This is…”
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Total Synthesis of Spongistatin 1: A Synthetic Strategy Exploiting Its Latent Pseudo-Symmetry by Ball, Matthew, Gaunt, Matthew J., Hook, David F., Jessiman, Alan S., Kawahara, Shigeru, Orsini, Paolo, Scolaro, Alessandra, Talbot, Adam C., Tanner, Huw R., Yamanoi, Shigeo, Ley, Steven V.

“…The challenging structure and potent growth inhibition properties against a variety of human cancer cell lines make Spongistatin 1 (1) an exciting target for…”
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Synthesis of the C-1−C-28 ABCD Unit of Spongistatin 1 by Gaunt, Matthew J, Jessiman, Alan S, Orsini, Paolo, Tanner, Huw R, Hook, David F, Ley, Steven V

“…The synthesis of the C-1−C-28 ABCD fragment of spongistatin is described. Anti-selective boron-mediated aldol coupling of a CD spiroketal ketone fragment to an…”
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Nonlinear indentation of single human erythrocytes under application of a localized mechanical force by Tognoni, Elisabetta, Orsini, Paolo, Pellegrino, Mario

“…•The local elasticity of single human erythrocytes was measured.•The Young’s modulus ranged from 0.2 to 1.5 kPa for 20 to 500 pN forces.•We observed a…”
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