Search Results - "ORMISTON, Mark L"

Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2 by Caruso, Paola, Dunmore, Benjamin J, Schlosser, Kenny, Schoors, Sandra, Dos Santos, Claudia, Perez-Iratxeta, Carol, Lavoie, Jessie R, Zhang, Hui, Long, Lu, Flockton, Amanda R, Frid, Maria G, Upton, Paul D, D'Alessandro, Angelo, Hadinnapola, Charaka, Kiskin, Fedir N, Taha, Mohamad, Hurst, Liam A, Ormiston, Mark L, Hata, Akiko, Stenmark, Kurt R, Carmeliet, Peter, Stewart, Duncan J, Morrell, Nicholas W

“…Pulmonary arterial hypertension (PAH) is characterized by abnormal growth and enhanced glycolysis of pulmonary artery endothelial cells. However, the…”
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MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype by Hong, Zhigang, Chen, Kuang-Hueih, DasGupta, Asish, Potus, Francois, Dunham-Snary, Kimberly, Bonnet, Sebastien, Tian, Lian, Fu, Jennifer, Breuils-Bonnet, Sandra, Provencher, Steeve, Wu, Danchen, Mewburn, Jeffrey, Ormiston, Mark L, Archer, Stephen L

“…Pulmonary arterial hypertension (PAH) is an obstructive vasculopathy characterized by excessive pulmonary artery smooth muscle cell (PASMC) proliferation,…”
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Novel Pathways for Targeting Tumor Angiogenesis in Metastatic Breast Cancer by Harry, Jordan A, Ormiston, Mark L

“…Breast cancer is the most common cancer affecting women and is the second leading cause of cancer related death worldwide. Angiogenesis, the process of new…”
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A Potential Role for Exosomal Translationally Controlled Tumor Protein Export in Vascular Remodeling in Pulmonary Arterial Hypertension by Ferrer, Elisabet, Dunmore, Benjamin J, Hassan, Dhiya, Ormiston, Mark L, Moore, Stephen, Deighton, John, Long, Lu, Yang, Xu Dong, Stewart, Duncan J, Morrell, Nicholas W

“…Pulmonary arterial hypertension (PAH) is characterized by increased proliferation and resistance to apoptosis of pulmonary vascular cells. Increased expression…”
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The Production of Pro-angiogenic VEGF-A Isoforms by Hypoxic Human NK Cells Is Independent of Their TGF-β-Mediated Conversion to an ILC1-Like Phenotype by Hawke, Lindsey G, Whitford, Mara K M, Ormiston, Mark L

“…Circulating natural killer (NK) cells have been shown to adopt a type 1 innate lymphoid cell (ILC1)-like phenotype in response to TGF-β and secrete VEGF-A when…”
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Proteomic Analysis Implicates Translationally Controlled Tumor Protein as a Novel Mediator of Occlusive Vascular Remodeling in Pulmonary Arterial Hypertension by Lavoie, Jessie R, Ormiston, Mark L, Perez-Iratxeta, Carol, Courtman, David W, Jiang, Baohua, Ferrer, Elisabet, Caruso, Paola, Southwood, Mark, Foster, William S, Morrell, Nicholas W, Stewart, Duncan J

“…BACKGROUND—Pulmonary arterial hypertension (PAH) is a lethal disease characterized by excessive proliferation of pulmonary vascular endothelial cells (ECs)…”
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A sex-specific reconstitution bias in the competitive CD45.1/CD45.2 congenic bone marrow transplant model by Jafri, Salema, Moore, Stephen D., Morrell, Nicholas W., Ormiston, Mark L.

“…Allelic variants of the pan-haematopoietic cell marker CD45, identified as CD45.1 and CD45.2, have been established as a marker system to track haematopoietic…”
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Impaired Natural Killer Cell Phenotype and Function in Idiopathic and Heritable Pulmonary Arterial Hypertension by ORMISTON, Mark L, CHIWEN CHANG, SOUTHWOOD, Mark, PEPKE-ZABA, Joanna, EXLEY, Andrew, TREMBATH, Richard C, COLUCCI, Francesco, WILLS, Mark, TROWSDALE, John, MORRELL, Nicholas W, LONG, Lu L, SOON, Elaine, JONES, Des, MACHADO, Rajiv, TREACY, Carmen, TOSHNER, Mark R, CAMPBELL, Kate, RIDING, Alex

“…Beyond their role as innate immune effectors, natural killer (NK) cells are emerging as important regulators of angiogenesis and vascular remodeling. Pulmonary…”
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Pulmonary arterial hypertension: pathogenesis and clinical management by Thenappan, Thenappan, Ormiston, Mark L, Ryan, John J, Archer, Stephen L

“…ABSTRACTPulmonary hypertension is defined as a resting mean pulmonary artery pressure of 25 mm Hg or above. This review deals with pulmonary arterial…”
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Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells by Toshner, Mark, Dunmore, Benjamin J, McKinney, Eoin F, Southwood, Mark, Caruso, Paola, Upton, Paul D, Waters, John P, Ormiston, Mark L, Skepper, Jeremy N, Nash, Gerard, Rana, Amer A, Morrell, Nicholas W

“…The endothelial cell has a remarkable ability for sub-specialisation, adapted to the needs of a variety of vascular beds. The role of developmental programming…”
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Editorial: Molecular Mechanisms in Pulmonary Hypertension and Right Ventricle Dysfunction by Karmouty-Quintana, Harry, Guignabert, Christophe, Kwapiszewska, Grazyna, Ormiston, Mark L

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Immune regulation of systemic hypertension, pulmonary arterial hypertension, and preeclampsia: shared disease mechanisms and translational opportunities by Jafri, Salema, Ormiston, Mark L

“…Systemic hypertension, preeclampsia, and pulmonary arterial hypertension (PAH) are diseases of high blood pressure in the systemic or pulmonary circulation…”
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A Practical and Efficient Cellular Substrate for the Generation of Induced Pluripotent Stem Cells from Adults: Blood‐Derived Endothelial Progenitor Cells by Geti, Imbisaat, Ormiston, Mark L., Rouhani, Foad, Toshner, Mark, Movassagh, Mehregan, Nichols, Jennifer, Mansfield, William, Southwood, Mark, Bradley, Allan, Rana, Amer Ahmed, Vallier, Ludovic, Morrell, Nicholas W.

“…This report describes the use of late‐outgrowth endothelial progenitor cells (L‐EPCs), as a cellular substrate for the generation of induced pluripotent stem…”
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TGF-β and IL-15 Synergize through MAPK Pathways to Drive the Conversion of Human NK Cells to an Innate Lymphoid Cell 1-like Phenotype by Hawke, Lindsey G, Mitchell, Brandon Z, Ormiston, Mark L

“…Circulating NK cells are known to convert to a type 1 innate lymphoid cell (ILC1)-like phenotype in response to TGF-β exposure. However, the precise cellular…”
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Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension by Long, Lu, Ormiston, Mark L, Yang, Xudong, Southwood, Mark, Gräf, Stefan, Machado, Rajiv D, Mueller, Matthias, Kinzel, Bernd, Yung, Lai Ming, Wilkinson, Janine M, Moore, Stephen D, Drake, Kylie M, Aldred, Micheala A, Yu, Paul B, Upton, Paul D, Morrell, Nicholas W

“…BMP9 activates signaling through the BMPR-II receptor in endothelial cells and reverses established disease in three animal models of pulmonary hypertension,…”
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Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications by Chen, Kuang-Hueih, Dasgupta, Asish, Lin, Jianhui, Potus, François, Bonnet, Sébastien, Iremonger, James, Fu, Jennifer, Mewburn, Jeffrey, Wu, Danchen, Dunham-Snary, Kimberly, Theilmann, Anne L, Jing, Zhi-Cheng, Hindmarch, Charles, Ormiston, Mark L, Lawrie, Allan, Archer, Stephen L

“…Mitotic fission is increased in pulmonary arterial hypertension (PAH), a hyperproliferative, apoptosis-resistant disease. The fission mediator dynamin-related…”
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Evolving Concepts in Endothelial Pathobiology of Pulmonary Arterial Hypertension by Cober, Nicholas D., VandenBroek, M. Martin, Ormiston, Mark L., Stewart, Duncan J.

“…Pulmonary arterial hypertension (PAH) is a deadly disease, characterized by increased vascular resistance, pulmonary arteriolar loss, and occlusive arterial…”
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IFN-β activates cytotoxic function of human natural killer cells toward IL-27 and poly(I:C) stimulated PC3 and DU145 cells by Kourko, Olena, Hawke, Lindsey G., Ormiston, Mark L., Gee, Katrina

“…•NK cell activity is positively correlated with a good prognosis in prostate cancer.•Combining IL-27 and poly(I:C) may have therapeutic potential for prostate…”
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Oh NO! Loss of PHD2 leads to "radical" changes in the lung vasculature by Ormiston, Mark L, Jankov, Robert P, Stewart, Duncan J

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Repurposing benzbromarone for pulmonary arterial hypertension: can channelling the past deliver the therapy of the future? by Theilmann, Anne L, Ormiston, Mark L

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