Search Results - "ORJIH, A. U"

On the mechanism of hemozoin production in malaria parasites: activated erythrocyte membranes promote beta-hematin synthesis by Orjih, A U

“…The ferriprotoporphyrin IX (FP) molecules released by intraerythrocytic malaria parasites during hemoglobin digestion are converted to beta-hematin and are…”
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Malaria parasite metabolism in sickle cells by Orjih, A. U.

“…:  Intraerythrocytic malaria parasites meet part of their growth requirements by ingesting and digesting haemoglobin (Hb). To see whether this process is…”
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Haemolysis of Plasmodium falciparum trophozoite-infected erythrocytes after artemisinin exposure by Orjih, A U

“…This study has examined in vitro, how exposure to the antimalarial drug artemisinin affects Plasmodium falciparum and its host erythrocytes. Factors examined…”
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Hemoglobin catabolism and the killing of intraerythrocytic Plasmodium falciparum by chloroquine by Orjih, A U, Ryerse, J S, Fitch, C D

“…To evaluate how chloroquine kills malaria parasites, hemoglobin catabolism was studied at the various stages of intraerythrocytic parasite development. We…”
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Increased accumulation of chloroquine and desethylchloroquine in homozygous sickle cells by ORJIH, A. U

“…The effect of haemoglobin genotype on the level of chloroquine in the erythrocytes of homozygous sickle-cell (SS), normal (AA), and heterozygous (AS) subjects…”
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Acute malaria prolongs susceptibility of mice to Plasmodium berghei sporozoite infection by ORJIH, A. U

“…The fate of immune response against sporozoite stage in malaria infection was investigated. Two groups (A and B) of mice were inoculated twice with infective…”
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Toxic heme in sickle cells: an explanation for death of malaria parasites by Orjih, A U, Chevli, R, Fitch, C D

“…In an effort to elucidate a mechanism of genetic resistance to malaria, we asked whether a toxic form of heme is included in the excess of ferriprotoporphyrin…”
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A rapid in vitro test for chloroquine-resistant Plasmodium falciparum by Gluzman, I Y, Krogstad, D J, Orjih, A U, Nkangineme, K, Wellems, T E, Martin, J T, Schlesinger, P H

“…We report a rapid (2-3 hr) in vitro test for chloroquine resistance in Plasmodium falciparum. The test is based on the inhibition of chloroquine efflux by…”
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Hemozoin production by Plasmodium falciparum: variation with strain and exposure to chloroquine by Orjih, A U, Fitch, C D

“…Synchronized Plasmodium falciparum parasites were grown in erythrocytic culture for measurement of malaria pigment (hemozoin) production using a simple method…”
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Plasmodium berghei: suppression of antibody response to sporozoite stage by acute blood stage infection by Orjih, A U, Nussenzweig, R S

“…Mice infected with the erythrocytic stages of Plasmodium berghei show an impaired host response to immunization with irradiated sporozoites of the same…”
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Heme polymerase activity and the stage specificity of antimalarial action of chloroquine by Orjih, A U

“…Plasmodium falciparum lysate, prepared from 2.7 x 10(7) ring-infected erythrocytes and incubated with hemoglobin in sodium acetate at pH 5, incorporated a mean…”
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Ferriprotoporphyrin IX and cell lysis: a protective role for hydrogen peroxide by Orjih, A U, Kanjananggulpan, P, Fitch, C D

“…Two potentially lytic substances, ferriprotoporphyrin IX (FP) and hydrogen peroxide, may coexist and partially detoxify each other in sickle cells and in…”
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Comparative studies on the immunogenicity of infective and attenuated sporozoites of Plasmodium berghei by Orjih, A U, Cochrane, A H, Nussenzweig, R S

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Immunofluorescent Staining of Exoerythrocytic Schizonts of Plasmodium berghei in Fixed Liver Tissue with Stage-Specific Immune Serum by Danforth, Harry D., Orjih, Augustine U., Nusseniweig, Ruth S.

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Immunization against rodent malaria with cryopreserved irradiated sporozoites of Plasmodium berghei by Orjih, A U, Nussenzweig, R S

“…The preparation and storage of Plasmodium berghei sporozoites for immunization purposes is described. The sporozoites were harvested from the salivary glands…”
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Hemin Lyses Malaria Parasites by Orjih, Augustine U., Banyal, H. S., Chevli, Rekha, Fitch, Coy D.

“…Malaria parasites isolated from mouse erythrocytes are lysed by ferriprotoporphyrin IX chloride (hemin) or by a chloroquine-hemin complex in amounts that could…”
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Active immunization and passive transfer of resistance against sporozoite-induced malaria in infant mice by Orjih, Augustine U, Cochrane, Alan H, Nussenzweig, Ruth S

“…Immunization attempts using a variety of plasmodial preparations have identified several developmental stages and vaccination procedures which can protect…”
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Dried blood for immunofluorescent test--a modified method of smearing and extraction by Orjih, A U

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Comparison of Plasmodium falciparum growth in sickle cells in low oxygen environment and candle-jar by Orjih, Augustine U.

“…The first successful in vitro cultivation of Plasmodium falciparum in sickle cells in a gas mixture containing 3% oxygen, 4% carbon dioxide and 93% nitrogen…”
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Saponin haemolysis for increasing concentration of Plasmodium falciparum infected erythrocytes by Orjih, A U

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