Search Results - "ORENGO, C. A"

CATH – a hierarchic classification of protein domain structures by Orengo, CA, Michie, AD, Jones, S, Jones, DT, Swindells, MB, Thornton, JM

“…Background: Protein evolution gives rise to families of structurally related proteins, within which sequence identities can be extremely low. As a result,…”
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One session cognitive behavioural therapy for elderly patients with chronic obstructive pulmonary disease by Kunik, M E, Braun, U, Stanley, M A, Wristers, K, Molinari, V, Stoebner, D, Orengo, C A

“…We hypothesized that compared to an educational intervention, a single 2 h session of cognitive behavioural therapy (CBT), with 6-week follow-up, would reduce…”
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The CATH database: an extended protein family resource for structural and functional genomics by Pearl, F. M. G., Bennett, C. F., Bray, J. E., Harrison, A. P., Martin, N., Shepherd, A., Sillitoe, I., Thornton, J., Orengo, C. A.

“…The CATH database of protein domain structures (http://www.biochem.ucl.ac.uk/bsm/cath_new) currently contains 34 287 domain structures classified into 1383…”
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FFPred: an integrated feature-based function prediction server for vertebrate proteomes by Lobley, A.E, Nugent, T, Orengo, C.A, Jones, D.T

“…One of the challenges of the post-genomic era is to provide accurate function annotations for large volumes of data resulting from genome sequencing projects…”
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SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals by Lam, S. D., Bordin, N., Waman, V. P., Scholes, H. M., Ashford, P., Sen, N., van Dorp, L., Rauer, C., Dawson, N. L., Pang, C. S. M., Abbasian, M., Sillitoe, I., Edwards, S. J. L., Fraternali, F., Lees, J. G., Santini, J. M., Orengo, C. A.

“…SARS-CoV-2 has a zoonotic origin and was transmitted to humans via an undetermined intermediate host, leading to infections in humans and other mammals. To…”
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Protein superfamilies and domain superfolds by Orengo, C.A, Jones, D.T, Thornton, J.M

“…As the protein sequence and structure databases expand rapidly a better understanding of the relationships between proteins is required. A classification is…”
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CATH classification revisited--architectures reviewed and new ways to characterize structural divergence in superfamilies by Cuff, Alison L, Sillitoe, Ian, Lewis, Tony, Redfern, Oliver C, Garratt, Richard, Thornton, Janet, Orengo, Christine A

“…The latest version of CATH (class, architecture, topology, homology) (version 3.2), released in July 2008 (http://www.cathdb.info), contains 1 14 215 domains,…”
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The CATH domain structure database: new protocols and classification levels give a more comprehensive resource for exploring evolution by Greene, Lesley H., Lewis, Tony E., Addou, Sarah, Cuff, Alison, Dallman, Tim, Dibley, Mark, Redfern, Oliver, Pearl, Frances, Nambudiry, Rekha, Reid, Adam, Sillitoe, Ian, Yeats, Corin, Thornton, Janet M., Orengo, Christine A.

“…We report the latest release (version 3.0) of the CATH protein domain database (). There has been a 20% increase in the number of structural domains classified…”
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CORA—Topological fingerprints for protein structural families by ORENGO, CHRISTINE ANNE

“…CORA is a suite of programs for multiply aligning and analyzing protein structural families to identify the consensus positions and capture their most…”
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Identification and classification of protein fold families by Orengo, C A, Flores, T P, Taylor, W R, Thornton, J M

“…We have developed a method for identifying fold families in the protein structure data bank. Pairwise sequence alignments are first performed to extract…”
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CATH database provides insights into protein structure/function relationships by Orengo, C.A, Pearl, F.M.G, Bray, J.E, Todd, A.E, Martin, A.C, Lo Conte, L, Thornton, J.M

“…We report the latest release (version 1.4) of the CATH protein domains database (http://www.biochem.ucl.ac.uk/bsm/cath). This is a hierarchical classification…”
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Protein structure alignment by Taylor, W R, Orengo, C A

“…A new method of comparing protein structures is described, based on distance plot analysis. It is relatively insensitive to insertions and deletions in…”
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Evolution of function in protein superfamilies, from a structural perspective by Todd, A E, Orengo, C A, Thornton, J M

“…The recent growth in protein databases has revealed the functional diversity of many protein superfamilies. We have assessed the functional variation of…”
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Comparison of conformational characteristics in structurally similar protein pairs by Flores, T.P., Orengo, C.A., Moss, D.S., Thornton, J.M.

“…Although it is known that three‐dimensional structure is well conserved during the evolutionary development of proteins, there have been few studies that…”
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Systematic computational prediction of protein interaction networks by Lees, J G, Heriche, J K, Morilla, I, Ranea, J A, Orengo, C A

“…Determining the network of physical protein associations is an important first step in developing mechanistic evidence for elucidating biological pathways…”
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Fast structure alignment for protein databank searching by Orengo, C A, Brown, N P, Taylor, W R

“…A fast method is described for searching and analyzing the protein structure databank. It uses secondary structure followed by residue matching to compare…”
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The CATH Dictionary of Homologous Superfamilies (DHS): a consensus approach for identifying distant structural homologues by Bray, J.E., Todd, A.E., Pearl, F.M.G., Thornton, J.M., Orengo, C.A.

“…A consensus approach has been developed for identifying distant structural homologues. This is based on the CATH Dictionary of Homologous Superfamilies (DHS),…”
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Multiple protein structure alignment by Taylor, William R., Flores, Tomas P., Orengo, Christine A.

“…A method was developed to compare protein structures and to combine them into a multiple structure consensus. Previous methods of multiple structure comparison…”
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The efficacy and tolerability of divalproex sodium in elderly demented patients with behavioral disturbances by Kunik, Mark E., Puryear, Lucy, Orengo, Claudia A., Molinari, Victor, Workman Jr, Richard H.

“…Behavioral disturbances are commonly encountered in elderly demented patients. The records of all patients admitted to a geropsychiatric inpatient unit within…”
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Combining sensitive database searches with multiple intermediates to detect distant homologues by Salamov, Asaf A., Suwa, Makiko, Orengo, Christine A., Swindells, Mark B.

“…Using data from the CATH structure classification, we have assessed the blastp, fasta, smith–waterman and gapped-blast algorithms, developed a portable…”
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