Effect of ketamine on cerebral cortical blood flow and metabolism in rabbits

Effect of ketamine on cerebral cortical blood flow and metabolism in rabbits

The effects of intravenous ketamine (1 mg/kg) on cerebral cortical blood flow and O2 uptake were evaluated in 13 anesthetized, ventilated rabbits. Blood flow was measured either directly (Group 1) or by the H2 clearance method (Group 2). In those animals of Groups 1 and 2 with normal control arteria...

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Bibliographic Details
Published in:Stroke (1970) Vol. 18; no. 2; pp. 441 - 444
Main Authors: OREN, R. E, RASOOL, N. A, RUBINSTEIN, E. H
Format: Journal Article
Language:English
Published: Hagerstown, MD Lippincott Williams & Wilkins 01-03-1987
Subjects:
Anesthetics. Neuromuscular blocking agents
Animals
Biological and medical sciences
Blood Pressure - drug effects
Cerebral Cortex - blood supply
Cerebral Cortex - metabolism
Hydrogen-Ion Concentration
Injections, Intravenous
Ketamine - pharmacology
Male
Medical sciences
Neuropharmacology
Oxygen Consumption - drug effects
Pharmacology. Drug treatments
Rabbits
Regional Blood Flow - drug effects
Cerebral cortex
Oxygen
Intravenous administration
Rabbit
Brain (Vertebrata)
Lagomorpha
Metabolism
Vasodilation
Blood flow
Vertebrata
Cholinergic receptor
Mammalia
Analgesic
Animal
Hemodynamics
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Summary:The effects of intravenous ketamine (1 mg/kg) on cerebral cortical blood flow and O2 uptake were evaluated in 13 anesthetized, ventilated rabbits. Blood flow was measured either directly (Group 1) or by the H2 clearance method (Group 2). In those animals of Groups 1 and 2 with normal control arterial pH (pHa), ketamine produced a significant increase in cerebral cortical blood flow of 18 and 34%, respectively, but had no effect on cerebral cortical O2 uptake. However, in rabbits with low control pHa, ketamine caused an increase in blood flow (30%) accompanied by a significant increase in O2 uptake (22%). Ketamine produced nonsignificant changes in mean arterial blood pressure and arterial blood gases, except for a significant reduction in pressure in animals with low pHa. It is concluded that ketamine is a cerebral vasodilator without cerebral metabolic effect when mean arterial blood pressure and arterial PCO2, PO2, and pH are held constant at physiologic levels. The vasodilator effect of ketamine is probably due to direct dilating action or activation of a cholinergic cerebral vasodilator system.
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ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.18.2.441