Search Results - "ORAWSKI, A. T"

Effect of a new aminopeptidase P inhibitor, apstatin, on bradykinin degradation in the rat lung by Prechel, M M, Orawski, A T, Maggiora, L L, Simmons, W H

“…Bradykinin (Bk), a potent vasoactive and cardioprotective peptide hormone, is almost completely inactivated during a single circulation through the rat lung…”
Get more information

Membrane-bound aminopeptidase P from bovine lung. Its purification, properties, and degradation of bradykinin by SIMMONS, W. H, ORAWSKI, A. T

“…The membrane-bound form of aminopeptidase P (aminoacylprolyl-peptide hydrolase) (EC 3.4.11.9) was purified to apparent homogeneity from bovine lung microsomes…”
Get full text

Apstatin Analogue Inhibitors of Aminopeptidase P, a Bradykinin-Degrading Enzyme by Maggiora, Linda L, Orawski, Arthur T, Simmons, William H

“…Membrane-bound aminopeptidase P (AP-P) participates in the degradation of bradykinin in several vascular beds. We have developed an inhibitor of AP-P called…”
Get full text

Active and Inactive Forms of the Transition-state Analog Protease Inhibitor Leupeptin: Explanation of the Observed Slow Binding of Leupeptin to Cathepsin B and Papain by Schultz, R M, Varma-Nelson, P, Ortiz, R, Kozlowski, K A, Orawski, A T, Pagast, P, Frankfater, A

“…Leupeptin and similar peptide argininal (arginine aldehyde) transition-state analog protease inhibitors exist in three covalent forms in aqueous solution, the…”
Get full text

Dipeptidase activities in rat brain synaptosomes can be distinguished on the basis of inhibition by bestatin and amastatin : identification of a kyotorphin (Tyr-Arg)-degrading enzyme by ORAWSKI, A. T, SIMMONS, W. H

“…The neuropeptide kyotorphin (Tyr-Arg) was degraded by rat brain synaptosomes via a synaptic membrane-bound peptidase which was inhibited by bestatin but not by…”
Get full text

Aminopeptidase P from bovine lung: solubilization, properties, and potential role in bradykinin degradation by Orawski, A T, Susz, J P, Simmons, W H

“…Aminopeptidase P was solubilized from bovine lung by sodium deoxycholate extraction of salt-washed, delipidated lung acetone powders. Hydrolysis of the…”
Get full text

Degradation of bradykinin and its metabolites by rat brain synaptic membranes by Orawski, A T, Simmons, W H

“…Bradykinin (BK) (Arg1-Pro2-Pro3-Gly4-Phe5-Ser6-Pro7-Phe8-Arg9) was degraded by rat brain synaptic membranes at a rate comparable to that found for…”
Get more information

Substrate specificity of aminopeptidase P from Escherichia coli: comparison with membrane-bound forms from rat and bovine lung by Yoshimoto, T, Orawski, A T, Simmons, W H

“…The substrate specificity of recombinant E. coli aminopeptidase P (aminoacylprolylpeptide hydrolase) (EC 3.4.11.9) was studied using about 150 synthetic…”
Get more information

Purification and Properties of Membrane-Bound Aminopeptidase P from Rat Lung by Orawski, Arthur T, Simmons, William H

“…The membrane-bound form of aminopeptidase P (aminoacylprolyl-peptide hydrolase) (EC 3.4.11.9) was purified 670-fold to apparent homogeneity from rat lung…”
Get full text

Metabolism of bradykinin by multiple coexisting membrane-bound peptidases in lung: techniques for investigating the role of each peptidase using specific inhibitors by Orawski, A T, Susz, J P, Simmons, W H

Get more information

Nutrition and somatomedin. III. Diabetic control, somatomedin, and growth in rats by Phillips, L S, Orawski, A T

“…Observations of a growth hormone-resistant decrease in somatomedin activity associated with conditions of insulinopenia suggest that somatomedin and growth…”
Get full text

Aminopeptidase P isozyme expression in human tissues and peripheral blood mononuclear cell fractions by Erşahin, Çağatay, Szpaderska, Anna M., Orawski, Arthur T., Simmons, William H.

“…Aminopeptidase P (APP) isoforms specifically remove the N-terminal amino acid from peptides that have a proline residue in the second position. The mRNA levels…”
Get full text

Somatomedin and nutrition. IV. Regulation of somatomedin activity and growth cartilage activity by quantity and composition of diet in rats by Phillips, L S, Orawski, A T, Belosky, D C

Get more information

Aminopeptidase P: purification of a membrane-bound bradykininase from rat lung by Orawski, A T, Simmons, W H

“…Aminopeptidase P that hydrolyzes the Arg1-Pro2-bond of bradykinin was solubilized from rat lung microsomes using phosphatidylinositol-specific phospholipase C…”
Get more information