Search Results - "OPPENHEIM, Joost J"

Alarmins and immunity by Yang, De, Han, Zhen, Oppenheim, Joost J.

“…Summary More than a decade has passed since the conceptualization of the “alarmin” hypothesis. The alarmin family has been expanding in terms of both number…”
Get full text

Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer by Chen, Xin, Oppenheim, Joost J

“…Tumor necrosis factor receptor 2 (TNFR2) is expressed both by some cancer cells and by tumor-infiltrating immunosuppressive CD4 FoxP3 regulatory T cells (T )…”
Get more information

Th17 cells and Tregs: unlikely allies by Chen, Xin, Oppenheim, Joost J.

“…Review on the reciprocal stimulatory effects of proinflammatory Th17 cells, wth immunosuppressive Treg cells. Identification of CD4+Foxp3+ Tregs and Th17…”
Get full text

Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function by Alam, Md Masud, Yang, De, Li, Xiao-Qing, Liu, Jia, Back, Timothy Carrel, Trivett, Anna, Karim, Baktiar, Barbut, Denise, Zasloff, Michael, Oppenheim, Joost J.

“…Alpha-synuclein (αS) is causally involved in the development of Parkinson disease (PD); however, its role in normal vertebrate physiology has remained unknown…”
Get full text

A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity by Stolzenberg, Ethan, Berry, Deborah, Yang, De, Lee, Ernest Y., Kroemer, Alexander, Kaufman, Stuart, Wong, Gerard C.L., Oppenheim, Joost J., Sen, Supti, Fishbein, Thomas, Bax, Ad, Harris, Brent, Barbut, Denise, Zasloff, Michael A.

“…Background: Alpha-synuclein (αS) is a nerve cell protein associated with Parkinson disease (PD). Accumulation of αS within the enteric nervous system (ENS) and…”
Get full text

Cryptotanshinone has curative dual anti-proliferative and immunotherapeutic effects on mouse Lewis lung carcinoma by Liu, Shuo, Han, Zhen, Trivett, Anna L., Lin, Hongsheng, Hannifin, Sean, Yang, De, Oppenheim, Joost J.

“…Lung cancer is currently the leading cause of cancer-related mortality with very limited effective therapy. Screening of a variety of traditional Chinese…”
Get full text

High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin by Yang, De, Chen, Qian, Yang, Huan, Tracey, Kevin J., Bustin, Michael, Oppenheim, Joost J.

“…High mobility group box‐1 (HMGB1) protein is a nonhistone, DNA‐binding protein that plays a critical role in regulating gene transcription. Recently, HMGB1 has…”
Get full text

Alarmins and Antitumor Immunity by Nie, Yingjie, PhD, Yang, De, MD, PhD, Oppenheim, Joost J., MD

“…Abstract Purpose Alarmins are constitutively present endogenous molecules that essentially act as early warning signals for the immune system. We provide a…”
Get full text

Chemerin reveals its chimeric nature by Yoshimura, Teizo, Oppenheim, Joost J

“…Chemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1 on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An…”
Get full text

Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells by Yoshimura, Teizo, Howard, O M Zack, Ito, Toshihiro, Kuwabara, Masaki, Matsukawa, Akihiro, Chen, Keqiang, Liu, Ying, Liu, Mingyong, Oppenheim, Joost J, Wang, Ji Ming

“…MCP-1/CCL2 plays an important role in the initiation and progression of cancer. Since tumor cells produce MCP-1, they are considered to be the main source of…”
Get full text

Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer by Nie, Yingjie, He, Jiang, Shirota, Hidekazu, Trivett, Anna L, Yang, De, Klinman, Dennis M, Oppenheim, Joost J, Chen, Xin

“…Through the tumor necrosis factor (TNF) receptor type II (TNFR2), TNF preferentially activates, expands, and promotes the phenotypic stability of CD4 Foxp3…”
Get more information

High-mobility group nucleosome binding domain 1 (HMGN1) functions as a Th1-polarizing alarmin by Yang, De, Han, Zhen, Alam, Md Masud, Oppenheim, Joost J.

“…[Display omitted] •HMGN1, a member of the HMGN family proteins, binds nucleosomes to regulate chromatin structure, histone modification, and gene…”
Get full text

Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses by Yang, De, Chen, Qian, Su, Shao Bo, Zhang, Ping, Kurosaka, Kahori, Caspi, Rachel R, Michalek, Suzanne M, Rosenberg, Helene F, Zhang, Ning, Oppenheim, Joost J

“…Eosinophil-derived neurotoxin (EDN) is an eosinophil granule-derived secretory protein with ribonuclease and antiviral activity. We have previously shown that…”
Get full text

Painful pathways induced by TLR stimulation of dorsal root ganglion neurons by Qi, Jia, Buzas, Krisztina, Fan, Huiting, Cohen, Jeffrey I, Wang, Kening, Mont, Erik, Klinman, Dennis, Oppenheim, Joost J, Howard, O M Zack

“…We hypothesize that innate immune signals from infectious organisms and/or injured tissues may activate peripheral neuronal pain signals. In this study, we…”
Get full text

IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization by Yoon, Juhan, Leyva-Castillo, Juan Manuel, Wang, Guoxing, Galand, Claire, Oyoshi, Michiko K, Kumar, Lalit, Hoff, Sabine, He, Rui, Chervonsky, Alexander, Oppenheim, Joost J, Kuchroo, Vijay K, van den Brink, Marcel R M, Malefyt, Rene De Waal, Tessier, Philippe A, Fuhlbrigge, Robert, Rosenstiel, Philip, Terhorst, Cox, Murphy, George, Geha, Raif S

“…Atopic dermatitis (AD) is a Th2-dominated inflammatory skin disease characterized by epidermal thickening. Serum levels of IL-22, a cytokine known to induce…”
Get full text

Interleukin-8: An evolving chemokine by Matsushima, Kouji, Yang, De, Oppenheim, Joost J.

“…•IL-8/CXCL8 is the first chemokine discovered.•IL-8 acts on CXCR1/2 to control target cell adhesion, migration, and function.•IL-8 is a crucial regulator of…”
Get full text

High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses by Yang, De, Postnikov, Yuri V, Li, Yana, Tewary, Poonam, de la Rosa, Gonzalo, Wei, Feng, Klinman, Dennis, Gioannini, Theresa, Weiss, Jerrold P, Furusawa, Takashi, Bustin, Michael, Oppenheim, Joost J

“…Alarmins are endogenous mediators capable of promoting the recruitment and activation of antigen-presenting cells (APCs), including dendritic cells (DCs), that…”
Get full text

Development of a Curative Therapeutic Vaccine (TheraVac) for the Treatment of Large Established Tumors by Nie, Yingjie, Yang, De, Trivett, Anna, Han, Zhen, Xin, Haiyun, Chen, Xin, Oppenheim, Joost J.

“…Harnessing immune system to treat cancer requires simultaneous generation of tumor-specific CTLs and curtailment of tumor immunosuppressive environment. Here,…”
Get full text

HMGN1 and R848 Synergistically Activate Dendritic Cells Using Multiple Signaling Pathways by Alam, Md Masud, Yang, De, Trivett, Anna, Meyer, Thomas J, Oppenheim, Joost J

“…High mobility group nucleosome-binding protein 1 (HMGN1 or N1) is a Th1-polarizing alarmin, but alone is insufficient to induce antitumor immunity. We…”
Get full text

Lactoferrin Acts as an Alarmin to Promote the Recruitment and Activation of APCs and Antigen-Specific Immune Responses by de la Rosa, Gonzalo, Yang, De, Tewary, Poonam, Varadhachary, Atul, Oppenheim, Joost J

“…Lactoferrin is an 80-kDa iron-binding protein present at high concentrations in milk and in the granules of neutrophils. It possesses multiple activities,…”
Get full text