Search Results - "OPPELAAR, Hugo"

Cntn4, a risk gene for neuropsychiatric disorders, modulates hippocampal synaptic plasticity and behavior by Oguro-Ando, Asami, Bamford, Rosemary A., Sital, Wiedjai, Sprengers, Jan J., Zuko, Amila, Matser, Jolien M., Oppelaar, Hugo, Sarabdjitsingh, Angela, Joëls, Marian, Burbach, J. Peter. H., Kas, Martien J.

“…Neurodevelopmental and neuropsychiatric disorders, such as autism spectrum disorders (ASD), anorexia nervosa (AN), Alzheimer’s disease (AD), and schizophrenia…”
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Genetic Mapping in Mice Reveals the Involvement of Pcdh9 in Long-Term Social and Object Recognition and Sensorimotor Development by Bruining, Hilgo, Matsui, Asuka, Oguro-Ando, Asami, Kahn, René S, van‘t Spijker, Heleen M, Akkermans, Guus, Stiedl, Oliver, van Engeland, Herman, Koopmans, Bastijn, van Lith, Hein A, Oppelaar, Hugo, Tieland, Liselotte, Nonkes, Lourens J, Yagi, Takeshi, Kaneko, Ryosuke, Burbach, J. Peter H, Yamamoto, Nobuhiko, Kas, Martien J

“…Abstract Background Quantitative genetic analysis of basic mouse behaviors is a powerful tool to identify novel genetic phenotypes contributing to…”
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Identifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations by Pjetri, Eneda, de Haas, Ria, de Jong, Simone, Gelegen, Cigdem, Oppelaar, Hugo, Verhagen, Linda A W, Eijkemans, Marinus J C, Adan, Roger A, Olivier, Berend, Kas, Martien J

“…Animal studies are very useful in detection of early disease indicators and in unravelling the pathophysiological processes underlying core psychiatric…”
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Behavioral, physiological, and molecular differences in response to dietary restriction in three inbred mouse strains by Gelegen, Cigdem, Collier, David A, Campbell, Iain C, Oppelaar, Hugo, Kas, Martien J H

“…Food restriction paradigms are widely used in animal studies to investigate systems involved in energy regulation. We have observed behavioral, physiological,…”
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Hippocampal gene expression analysis highlights Ly6a/Sca-1 as candidate gene for previously mapped novelty induced behaviors in mice by de Jong, Simone, Kas, Martien J H, Kiernan, Jeffrey, de Mooij-van Malsen, Annetrude G, Oppelaar, Hugo, Janson, Esther, Vukobradovic, Igor, Farber, Charles R, Stanford, William L, Ophoff, Roel A

“…In this study, we show that the covariance between behavior and gene expression in the brain can help further unravel the determinants of neurobehavioral…”
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Targeting of a hydrophilic photosensitizer by use of internalizing monoclonal antibodies: A new possibility for use in photodynamic therapy by Vrouenraets, Maarten B., Visser, Gerard W.M., Loup, Christophe, Meunier, Bernard, Stigter, Marijke, Oppelaar, Hugo, Stewart, Fiona A., Snow, Gordon B., van Dongen, Guus A.M.S.

“…Coupling of photosensitizers to tumor‐selective monoclonal antibodies (MAbs) is an attractive option for improving the selectivity of photodynamic therapy…”
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Stratifying infants with cystic fibrosis for disease severity using intestinal organoid swelling as a biomarker of CFTR function by de Winter-de Groot, Karin M, Janssens, Hettie M, van Uum, Rick T, Dekkers, Johanna F, Berkers, Gitte, Vonk, Annelotte, Kruisselbrink, Evelien, Oppelaar, Hugo, Vries, Robert, Clevers, Hans, Houwen, Roderick H J, Escher, Johanna C, Elias, Sjoerd G, de Jonge, Hugo R, de Rijke, Yolanda B, Tiddens, Harm A W M, van der Ent, Cornelis K, Beekman, Jeffrey M

“…Forskolin-induced swelling (FIS) of intestinal organoids from individuals with cystic fibrosis (CF) measures function of the cystic fibrosis transmembrane…”
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Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression by Muilwijk, Danya, de Poel, Eyleen, van Mourik, Peter, Suen, Sylvia W.F., Vonk, Annelotte M., Brunsveld, Jesse E., Kruisselbrink, Evelien, Oppelaar, Hugo, Hagemeijer, Marne C., Berkers, Gitte, de Winter-de Groot, Karin M., Heida-Michel, Sabine, Jans, Stephan R., van Panhuis, Hannah, van der Eerden, Menno M., van der Meer, Renske, Roukema, Jolt, Dompeling, Edward, Weersink, Els J.M., Koppelman, Gerard H., Vries, Robert, Zomer-van Ommen, Domenique D., Eijkemans, Marinus J.C., van der Ent, Cornelis K., Beekman, Jeffrey M.

“…RATIONALECystic fibrosis (CF) is a monogenic life-shortening disease associated with highly variable individual disease progression which is difficult to…”
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Comparison of ex vivo and in vitro intestinal cystic fibrosis models to measure CFTR-dependent ion channel activity by Zomer-van Ommen, Domenique D., de Poel, Eyleen, Kruisselbrink, Evelien, Oppelaar, Hugo, Vonk, Annelotte M., Janssens, Hettie M., van der Ent, Cornelis K., Hagemeijer, Marne C., Beekman, Jeffrey M.

“…New functional assays using primary human intestinal adult stem cell cultures can be valuable tools to study epithelial defects in human diseases such as…”
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Interspecies Trait Genetics Reveals Association of Adcy8 with Mouse Avoidance Behavior and a Human Mood Disorder by de Mooij-van Malsen, Annetrude (J.G.), van Lith, Hein A, Oppelaar, Hugo, Hendriks, Judith, de Wit, Marina, Kostrzewa, Elżbieta, Breen, Gerome, Collier, David A, Olivier, Berend, Kas, Martien J

“…Background Identifying susceptibility genes for endophenotypes by studying analogous behaviors across species is an important strategy for understanding the…”
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Forskolin-induced Organoid Swelling is Associated with Long-term CF Disease Progression by Muilwijk, Danya, de Poel, Eyleen, van Mourik, Peter, Suen, Sylvia W F, Vonk, Annelotte M, Brunsveld, Jesse E, Kruisselbrink, Evelien, Oppelaar, Hugo, Hagemeijer, Marne C, Berkers, Gitte, de Winter-de Groot, Karin M, Heida-Michel, Sabine, Jans, Stephan R, van Panhuis, Hannah, van der Eerden, Menno M, van der Meer, Renske, Roukema, Jolt, Dompeling, Edward, Weersink, Els J M, Koppelman, Gerard H, Vries, Robert, Zomer-van Ommen, Domenique D, Eijkemans, Marinus J C, van der Ent, Cornelis K, Beekman, Jeffrey M

“…Cystic fibrosis (CF) is a monogenic life-shortening disease associated with highly variable individual disease progression which is difficult to predict. Here…”
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Marked inbred mouse strain difference in the expression of quinpirole induced compulsive like behavior based on behavioral pattern analysis by de Haas, Ria, Seddik, Amir, Oppelaar, Hugo, Westenberg, Herman G.M, Kas, Martien J.H

“…Abstract Obsessive–compulsive disorder (OCD) is a chronic and complex psychiatric disorder with a lifetime prevalence of 2–3%. Recent work has shown that OCD…”
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Difference in susceptibility to activity-based anorexia in two inbred strains of mice by Gelegen, Cigdem, Collier, David A, Campbell, Iain C, Oppelaar, Hugo, van den Heuvel, José, Adan, Roger A.H, Kas, Martien J.H

“…Abstract Food restricted rodents develop activity-based anorexia in the presence of a running wheel, characterised by increased physical activity, weight loss…”
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Targeting of aluminum (III) phthalocyanine tetrasulfonate by use of internalizing monoclonal antibodies : Improved efficacy in photodynamic therapy by VROUENRAETS, Maarten B, VISSER, Gerard W. M, STIGTER, Marijke, OPPELAAR, Hugo, SNOW, Gordon B, VAN DONGEN, Guus A. M. S

“…The use of monoclonal antibodies (MAbs) directed against tumor-associated antigens for targeting of photosensitizers is an interesting option to improve the…”
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Intraoperative photodynamic therapy after pleuropneumonectomy in patients with malignant pleural mesothelioma: dose finding and toxicity results by Schouwink, H, Rutgers, E T, van der Sijp, J, Oppelaar, H, van Zandwijk, N, van Veen, R, Burgers, S, Stewart, F A, Zoetmulder, F, Baas, P

“…To determine the optimal administered dose of meta-tetrahydroxyphenylchlorin (mTHPC) for intraoperative photodynamic therapy (IPDT) in resected malignant…”
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Comparison of aluminium (III) phthalocyanine tetrasulfonate‐ and meta‐tetrahydroxyphenylchlorin‐monoclonal antibody conjugates for their efficacy in photodynamic therapy in vitro by Vrouenraets, Maarten B., Visser, Gerard W.M., Stigter, Marÿke, Oppelaar, Hugo, Snow, Gordon B., van Dongen, Guus A.M.S.

“…A challenge in photodynamic therapy (PDT) is to improve the tumour selectivity of the photosensitizers by using monoclonal antibodies (MAbs). With this aim, we…”
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Phenotypic segregation of aphakia and Pitx3-null mutants reveals that Pitx3 deficiency increases consolidation of specific movement components by Kas, Martien J.H., van der Linden, Annemarie J.A., Oppelaar, Hugo, von Oerthel, Lars, Ramakers, Geert M.J., Smidt, Marten P.

“…Deficiency of the meso-diencephalic dopamine (mdDA) neuron specific transcription factor Pitx3 in aphakia ( ak) mice results in the loss of the substantia…”
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Development of meta-tetrahydroxyphenylchlorin-monoclonal antibody conjugates for photoimmunotherapy by VROUENRAETS, M. B, VISSER, G. W. M, STEWART, F. A, STIGTER, M, OPPELAAR, H, POSTMUS, P. E, SNOW, G. B, VAN DONGEN, G. A. M. S

“…A limitation of photodynamic therapy is the lack of tumor selectivity of the photosensitizer. To overcome this problem, a protocol was developed for coupling…”
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Photodynamic Therapy for Malignant Mesothelioma: Preclinical Studies for Optimization of Treatment Protocols by Schouwink, Hugo, Ruevekamp, Marjan, Oppelaar, Hugo, van Veen, Robert, Baas, Paul, Stewart, Fiona A.

“…Effective photodynamic therapy (PDT) depends on the optimization of factors such as drug dose, drug–light interval, fluence rate and total light dose (or…”
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Does tumour uptake of Foscan determine PDT efficacy? by Veenhuizen, Ruth, Oppelaar, Hugo, Ruevekamp, Marjan, Schellens, Jan, Dalesio, Otilia, Stewart, Fiona

“…Preferential retention of photosensitizers in tumours has always been one of the major goals in the search for new photosensitizers and has determined the…”
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