Search Results - "OPIE, LIONEL H"

Metabolic mechanisms in heart failure by ASHRAFIAN, Houman, FRENNEAUX, Michael P, OPIE, Lionel H

“…Although neurohumoral antagonism has successfully reduced heart failure morbidity and mortality, the residual disability and death rate remains unacceptably…”
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The Adrenergic-Fatty Acid Load in Heart Failure by Opie, Lionel H., MD, DPhil, DSc, Knuuti, Juhani, MD, PhD

“…The hypothesis proposed is that heart failure (HF) is associated with a reactive hyperadrenergic state that increases circulating plasma free fatty acids…”
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Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway by Lacerda, Lydia, Somers, Sarin, Opie, Lionel H., Lecour, Sandrine

“…Aims Ischaemic postconditioning (IPostC) is a powerful protective phenomenon that activates prosurvival intrinsic signalling cascades to limit reperfusion…”
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Role of toll-like receptor 4 in melatonin-induced cardioprotection by Nduhirabandi, Frederic, Lamont, Kim, Albertyn, Zulfah, Opie, Lionel H., Lecour, Sandrine

“…Melatonin protects the heart against myocardial ischemia/reperfusion injury via the activation of the survivor activating factor enhancement (SAFE) pathway…”
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Metabolic management of acute myocardial infarction comes to the fore and extends beyond control of hyperglycemia by Opie, Lionel H

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Trimetazidine, a Metabolic Modulator, Has Cardiac and Extracardiac Benefits in Idiopathic Dilated Cardiomyopathy by TUUNANEN, Helena, ENGBLOM, Erik, OPIE, Lionel H, KNUUTI, Juhani, NAUM, Alexandru, NAGREN, Kjell, SCHEININ, Mika, HESSE, Birger, JUHANI AIRAKSINEN, K. E, NUUTILA, Pirjo, IOZZO, Patricia, UKKONEN, Heikki

“…The anti-ischemic agent trimetazidine improves ejection fraction in heart failure that is hypothetically linked to inhibitory effects on cardiac free fatty…”
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Present status of statin therapy by Opie, Lionel H., MD, DPhil

“…Abstract Statins are cardioprotective agents that reduce the adverse effects of increased low-density lipoprotein cholesterol (LDL-C) levels. For significantly…”
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Role of melatonin, melatonin receptors and STAT3 in the cardioprotective effect of chronic and moderate consumption of red wine by Lamont, Kim, Nduhirabandi, Frederic, Adam, Tasneem, Thomas, D. Paul, Opie, Lionel H., Lecour, Sandrine

“…We have recently discovered that melatonin, given acutely and directly to the isolated heart at the concentration found in wine, confers cardioprotection…”
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A Proposal to Incorporate Trial Data Into a Hybrid American College of Cardiology/American Heart Association Algorithm for the Allocation of Statin Therapy in Primary Prevention by Opie, Lionel H., MD, DPhil

“…For primary prevention by a statin, a pre-treatment LDL-C level of 200 mg% (approximately 5 mmol/l) would substantially reduce the 10-year risk of a coronary…”
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Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol- and melatonin-induced cardioprotection by Lamont, Kim T., Somers, Sarin, Lacerda, Lydia, Opie, Lionel H., Lecour, Sandrine

“…:  Epidemiological studies suggest that regular moderate consumption of red wine confers cardioprotection but the mechanisms involved in this effect remain…”
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Early Intravenous Beta-Blockade Before Primary Percutaneous Coronary Intervention Gives Major Benefits, Apparently Without Side Effects by Opie, Lionel H., MD, DPhil

“…The treated group had few side effects, namely reversible and nonfatal heart block and hypotension. [...]in 2 large studies, beta-blockade had side-effects to…”
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Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure by TUUNANEN, Helena, ENGBLOM, Erik, KNUUTI, Juhani, NAUM, Alexandru, NAGREN, Kjell, HESSE, Birger, JUHANI AIRAKSINEN, K. E, NUUTILA, Pirjo, IOZZO, Patricia, UKKONEN, Heikki, OPIE, Lionel H

“…Metabolic modulators that enhance myocardial glucose metabolism by inhibiting free fatty acid (FFA) metabolism may improve cardiac function in heart failure…”
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HDL protects against ischemia reperfusion injury by preserving mitochondrial integrity by Frias, Miguel A, Pedretti, Sarah, Hacking, Damian, Somers, Sarin, Lacerda, Lydia, Opie, Lionel H, James, Richard W, Lecour, Sandrine

“…Abstract Objective High density lipoproteins (HDL) protect against ischemia reperfusion injury (IRI). However the precise mechanisms are not clearly…”
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Interplay Between SAFE and RISK Pathways in Sphingosine-1-Phosphate–Induced Cardioprotection by Somers, Sarin J., Frias, Miguel, Lacerda, Lydia, Opie, Lionel H., Lecour, Sandrine

“…Purpose We studied the role of two powerful molecular signalling mechanisms involved in the cardioprotective effect of sphingosine-1-phosphate (S1P), a major…”
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How strong is the evidence for use of beta-blockers as first-line therapy for hypertension? Systematic review and meta-analysis by BRADLEY, Hazel A, WIYSONGE, Charles Shey, VOLMINK, Jimmy A, MAYOSI, Bongani M, OPTE, Lionel H

“…To quantify the effect of first-line antihypertensive treatment with beta-blockers on mortality, morbidity and withdrawal rates, compared with the other main…”
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Very Early Administration of Glucose-Insulin-Potassium (GIK) by Emergency Medical Service for Acute Coronary Syndromes: Biological Mechanisms for Benefit in the IMMEDIATE Trial by Selker, Harry P., MD, MSPH, Harris, William S., PhD, Rackley, Charles E., MD, Marsh, Julian B., MD, Ruthazer, Robin, MPH, Beshansky, Joni R., RN, MPH, Rashba, Eric, MD, Peter, Inga, PhD, Opie, Lionel H., MD, DPhil

“…Abstract Aims In the IMMEDIATE Trial, intravenous glucose-insulin-potassium (GIK) was started as early as possible for patients with suspected acute coronary…”
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Allopurinol for Heart Failure by Opie, Lionel H., MD, DSc

“…[...]cytosolic CK then promotes the resynthesis of cytosolic ATP from cytosolic adenosine diphosphate, thus being an essential link in the overall sequence of…”
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Postconditioning for protection of the infarcting heart by Yellon, Derek M, Opie, Lionel H

“…Coronary heart disease is set to become the leading worldwide cause of death by 2020.1 Acute myocardial infarction is a major cause of such mortality and the…”
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Beta-blockers for hypertension by Wiysonge, Charles S, Bradley, Hazel A, Volmink, Jimmy, Mayosi, Bongani M, Opie, Lionel H

“…Beta-blockers refer to a mixed group of drugs with diverse pharmacodynamic and pharmacokinetic properties. They have shown long-term beneficial effects on…”
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Caloric Restriction Models Reverse Metabolic Syndrome by Opie, Lionel H., MD, DPhil, FRCP, FACC

“…Another example of reversed metabolic syndrome is the acute inhibition of lipolysis by acipimox, which abruptly reduced circulating FFAs in obese patients with…”
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