Search Results - "OOTSUYAMA, A"

p53-dependent delayed effects of radiation vary according to time of irradiation of p53 + / − mice by Okazaki, Ryuji, Ootsuyama, Akira

“…We previously reported that in p53 + / − mice that had been given a whole-body dose of 3 Gy at 8 weeks of age, p53-dependent delayed effects of radiation, as…”
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Threshold effect for teratogenic risk of radiation depends on dose-rate and p53 -dependent apoptosis by Kato, A. Ootsuyama, S. Nomoto, S. Kondo, T. Norimura, F.

“…Purpose : To obtain evidence that the p53 gene is indispensable for reduction of high teratogenic risk of radiation at a high dose-rate to zero risk by…”
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Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair by Kasai, H, Crain, P F, Kuchino, Y, Nishimura, S, Ootsuyama, A, Tanooka, H

“…8-Hydroxydeoxyguanosine (8-OH-dG) was detected in DNA isolated from HeLa cells after the cells in tissue culture had been irradiated with X-rays and from the…”
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Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA by Tanooka, H, Tatsumi, K, Tsuji, H, Noda, Y, Katsube, T, Ishii, H, Ootsuyama, A, Takeshita, F, Ochiya, T

“…To study the role of mutant p53 in the induction and cure of tumors, we generated transgenic mice carrying mutant p53 (m p53 ) containing a 9 bp deletion in…”
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Trabecular bone mass and bone formation are preserved after limb immobilisation in p53 null mice by Okazaki, R, Sakai, A, Ootsuyama, A, Sakata, T, Nakamura, T, Norimura, T

“…Objectives: To determine whether disruption of the p53 gene leads to preservation of trabecular bone volume (BV) after limb immobilisation. Materials and…”
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The high susceptibility of heterozygous p53(+/-) mice to malformation after foetal irradiation is related to sub-competent apoptosis by NOMOTO, S, OOTSUYAMA, A, SHIOYAMA, Y, KATSUKI, M, KONDO, S, NORIMURA, T

“…Purpose: To investigate the relationship between the incidence of radiation-induced malformations and the extent of p53-dependent apoptosis. Materials and…”
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Detection of radiation-induced mutations in the liver after partial hepatectomy using HITEC transgenic mice by Ootsuyama, A., Kato, F., Norimura, T.

“…We investigate the dynamics of radiation-specific mutations in a mammalian differentiated cell of the liver in the transgenic mouse called Hypersensitive In…”
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Threshold-Like Dose of Local β Irradiation Repeated Throughout the Life Span of Mice for Induction of Skin and Bone Tumors by Ootsuyama, Akira, Tanooka, Hiroshi

“…The backs of female ICR mice were irradiated with β rays from ^{90}{\rm Sr}-{}^{90}{\rm Y}$ three times a week throughout life. Previously we observed 100%…”
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Threshold-like dose response of mouse skin cancer induction by repeated beta irradiation and its relevance to radiation-induced human skin cancer by Tanooka, H, Ootsuyama, A

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Zero Tumor Incidence in Mice after Repeated Lifetime Exposures to 0.5 Gy of Beta Radiation by Ootsuyama, Akira, Tanooka, Hiroshi

“…A final series of experiments on tumor induction by repeating ^{90}{\rm Sr}-{}^{90}{\rm Y}$ β irradiation of the back of ICR mice three times weekly throughout…”
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Distribution of the p53 pseudogene among mouse species and subspecies by Tanooka, H, Ootsuyama, A, Shiroishi, T, Moriwaki, K

“…Pseudogenes may provide a useful marker for molecular taxonomy, since the rate of nucleotide substitutions for pseudogenes is much higher than that for…”
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One Hundred Percent Tumor Induction in Mouse Skin after Repeated β Irradiation in a Limited Dose Range by Ootsuyama, Akira, Tanooka, Hiroshi

“…Repeated β irradiation of the backs of mice three times a week with radiation doses of 250 to 1180 cGy per exposure induced 100% incidence of tumors. The…”
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Evidence by cellular mosaicism for monoclonal metastasis of spontaneous mouse mammary tumors by Ootsuyama, A, Tanaka, K, Tanooka, H

“…Female (SHN X C3H/He)F1 mice carrying spontaneous mammary tumors with cellular mosaicism with respect to isozymes of phosphoglycerate kinase (PGK) showed a…”
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TP53 and TP53-Related Genes Associated with Protection from Apoptosis in the Radioadaptive Response by Okazaki, Ryuji, Ootsuyama, Akira, Norimura, Toshiyuki

“…Okazaki, R., Ootsuyama, A. and Norimura, T. TP53 and TP53-Related Genes Associated with Protection from Apoptosis in the Radioadaptive Response. Radiat. Res…”
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Radioadaptive Response for Protection against Radiation-Induced Teratogenesis by Okazaki, R, Ootsuyama, A, Norimura, T

“…To clarify the characteristics of the radioadaptive response in mice, we compared the incidence of radiation-induced malformations in ICR mice. Pregnant ICR…”
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Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA by Tanooka, H, Tatsumi, K, Tsuji, H, Noda, Y, Katsube, T, Ishii, H, Ootsuyama, A, Takeshita, F, Ochiya, T

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Erratum: Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA by Tanooka, H, Tatsumi, K, Tsuji, H, Noda, Y, Katsube, T, Ishii, H, Ootsuyama, A, Takeshita, F, Ochiya, T

“…Correction to: Cancer Gene Therapy advance online publication 26 June 2009; doi:10.1038/cgt.2009.43 In this article, Figure 3 was missing the labels for the…”
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Radioadaptive Response for Protection against Radiation-Induced Teratogenesis by Okazaki, Ryuji, Ootsuyama, Akira, Norimura, Toshiyuki

“…Okazaki, R., Ootsuyama, A. and Norimura, T. Radioadaptive Response for Protection against Radiation-Induced Teratogenesis. Radiat. Res. 163, 266–270 (2005). To…”
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New antitumor promoters: (-)-epigallocatechin gallate and sarcophytols A and B by Fujiki, H, Suganuma, M, Suguri, H, Takagi, K, Yoshizawa, S, Ootsuyama, A, Tanooka, H, Okuda, T, Kobayashi, M, Sugimura, T

“…EGCG, the main constituent of green tea, and sarcophytols A and B, isolated from a soft coral, inhibited tumor promotion by teleocidin in a two-stage…”
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Prolonged Increase in T-Cell Receptor (TCR) Variant Fractions of Spleen T Lymphocytes in Pregnant Mice after γ Irradiation by Igari, Yuka, Igari, Kazuyuki, Kunugita, Naoki, Ootsuyama, Akira, Norimura, Toshiyuki

“…Igari, Y., Igari, K., Kunugita, N., Ootsuyama, A. and Norimura, T. Prolonged Increase in T-Cell Receptor (TCR) Variant Fractions of Spleen T Lymphocytes in…”
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