Relationship between light and dark period activity cycles and oral condition in senescence-accelerated mice

Relationship between light and dark period activity cycles and oral condition in senescence-accelerated mice

We investigated the effect of tooth absence and masticatory abnormalities due to powdered food feeding starting during the juvenile period on light and dark period activity cycles in senescence-accelerated mice (SAMP1) . SAMP1 were divided into 5 groups: Group 1, maxillo-mandibular molar tooth extra...

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Bibliographic Details
Published in:Okajimas Folia Anatomica Japonica Vol. 88; no. 1; pp. 29 - 36
Main Authors: IINUMA, Mitsuo, YASUI, Sayoko, OONISHI, Mika, KURATA, Chika, ICHIHASHI, Yukiko, TAMURA, Yasuo, KUBO, Kin-ya
Format: Journal Article
Language:English
Published: Japan Editorial Board of Okajimas Folia Anatomica Japonica 2011
Subjects:
activity cycles
Aging - pathology
Aging - physiology
Animals
Behavior, Animal - physiology
Chronobiology Disorders - complications
Chronobiology Disorders - physiopathology
Darkness
Dementia - diagnosis
Dementia - etiology
Dementia - physiopathology
Disease Models, Animal
Light
light and dark period
Male
Mice
Mice, Mutant Strains
Mouth, Edentulous - complications
Mouth, Edentulous - physiopathology
SAMP1
soft food
tooth extraction
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Summary:We investigated the effect of tooth absence and masticatory abnormalities due to powdered food feeding starting during the juvenile period on light and dark period activity cycles in senescence-accelerated mice (SAMP1) . SAMP1 were divided into 5 groups: Group 1, maxillo-mandibular molar tooth extraction; Group 2, maxillary molar tooth extraction; Group 3, mandibular molar tooth extraction; Group 4, powdered food; and Group 5, sham-operated control. Senescence was observed earliest in the powdered food group. Total 24-hour activity was higher in the control group than in the four other groups. In the powdered food group, the dark period activity decreased to less than 60% of the total activity in the 36th week. In the tooth extraction groups (Groups 1-3), dark period activity decreased to less than 60% of the total activity in the 40th week. The control group dark period activity remained above 60% for the entire experimental period. Thus, the distinction between the light and dark periods disappeared earlier in the four experimental groups compared with the control group. Significant correlations were noted among total activity, degree of senescence, and percent dark period activity in each experimental group. Functional masticatory insufficiency promoted dementia and behavioral abnormalities in SAMP1.
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content type line 23
ISSN:0030-154X
1881-1736
DOI:10.2535/ofaj.88.29