Search Results - "ONO, Mitsuaki"

OstemiR: a novel panel of microRNA biomarkers in osteoblastic and osteocytic differentiation from mesencymal stem cells by Eguchi, Takanori, Watanabe, Ken, Hara, Emilio Satoshi, Ono, Mitsuaki, Kuboki, Takuo, Calderwood, Stuart K

“…MicroRNAs (miRNAs) are small RNA molecules of 21-25 nucleotides that regulate cell behavior through inhibition of translation from mRNA to protein, promotion…”
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Cysteinyl leukotriene receptor 1 is dispensable for osteoclast differentiation and bone resorption by Fujita, Hirofumi, Ando, Aoi, Mizusawa, Yohei, Ono, Mitsuaki, Hattori, Takako, Habuta, Munenori, Oohashi, Toshitaka, Kubota, Satoshi, Ohuchi, Hideyo

“…Cysteinyl leukotriene receptor 1 (CysLTR1) is a G protein-coupled receptor for the inflammatory lipid mediators cysteinyl leukotrienes, which are involved in…”
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Anti-HMGB1 Neutralizing Antibody Attenuates Periodontal Inflammation and Bone Resorption in a Murine Periodontitis Model by Yoshihara-Hirata, Chiaki, Yamashiro, Keisuke, Yamamoto, Tadashi, Aoyagi, Hiroaki, Ideguchi, Hidetaka, Kawamura, Mari, Suzuki, Risa, Ono, Mitsuaki, Wake, Hidenori, Nishibori, Masahiro, Takashiba, Shogo

“…High mobility group box 1 (HMGB1) is a non-histone DNA-binding protein that is secreted into the extracellular milieu in response to inflammatory stimuli. The…”
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Unkeito Suppresses RANKL-Mediated Osteoclastogenesis via the Blimp1–Bcl6 and NF-κB Signaling Pathways and Enhancing Osteoclast Apoptosis by Fang, Ke, Murakami, Yuki, Kanda, Seiji, Shimono, Takaki, Dang, Anh Tuan, Ono, Mitsuaki, Nishiyama, Toshimasa

“…Osteoporosis is a common bone disease, particularly in menopausal women. Herein, we screened four Kampo medicines (Unkeito (UKT), Kamishoyosan (KSS),…”
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Local E-rhBMP-2/β-TCP Application Rescues Osteocyte Dendritic Integrity and Reduces Microstructural Damage in Alveolar Bone Post-Extraction in MRONJ-like Mouse Model by Dang, Anh Tuan, Ono, Mitsuaki, Wang, Ziyi, Tosa, Ikue, Hara, Emilio Satoshi, Mikai, Akihiro, Kitagawa, Wakana, Yonezawa, Tomoko, Kuboki, Takuo, Oohashi, Toshitaka

“…The pathology of medication-related osteonecrosis of the jaw (MRONJ), often associated with antiresorptive therapy, is still not fully understood. Osteocyte…”
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BMP-2/β-TCP Local Delivery for Bone Regeneration in MRONJ-Like Mouse Model by Mikai, Akihiro, Ono, Mitsuaki, Tosa, Ikue, Nguyen, Ha Thi Thu, Hara, Emilio Satoshi, Nosho, Shuji, Kimura-Ono, Aya, Nawachi, Kumiko, Takarada, Takeshi, Kuboki, Takuo, Oohashi, Toshitaka

“…Medication-related osteonecrosis of the jaw (MRONJ) is a severe pathological condition associated mainly with the long-term administration of bone resorption…”
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Lack of collagen α6(IV) chain in mice does not cause severe-to-profound hearing loss or cochlear malformation, a distinct phenotype from nonsyndromic hearing loss with COL4A6 missense mutation by Tang, Shaoying, Yonezawa, Tomoko, Maeda, Yukihide, Ono, Mitsuaki, Maeba, Takahiro, Miyoshi, Toru, Momota, Ryusuke, Tomono, Yasuko, Oohashi, Toshitaka

“…Congenital hearing loss affects 1 in every 1000 births, with genetic mutations contributing to more than 50% of all cases. X-linked nonsyndromic hereditary…”
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Resolvin D2 Induces Resolution of Periapical Inflammation and Promotes Healing of Periapical Lesions in Rat Periapical Periodontitis by Siddiqui, Yasir Dilshad, Omori, Kazuhiro, Ito, Takashi, Yamashiro, Keisuke, Nakamura, Shin, Okamoto, Kentaro, Ono, Mitsuaki, Yamamoto, Tadashi, Van Dyke, Thomas E, Takashiba, Shogo

“…Periapical periodontitis results from pulpal infection leading to pulpal necrosis and resorption of periapical bone. The current treatment is root canal…”
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Aging-Affected MSC Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model by Aung, Kyaw Thu, Akiyama, Kentaro, Kunitomo, Masayoshi, Mun, Aung Ye, Tosa, Ikue, Nguyen, Ha Thi Thu, Zhang, Jiewen, Kohno, Teisaku, Ono, Mitsuaki, Hara, Emilio Satoshi, Kuboki, Takuo

“…Mesenchymal stem cells (MSCs) are known to play important roles in the repair of lost or damaged tissues and immunotolerance. On the other hand, aging is known…”
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WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling by Maeda, Azusa, Ono, Mitsuaki, Holmbeck, Kenn, Li, Li, Kilts, Tina M., Kram, Vardit, Noonan, Megan L., Yoshioka, Yuya, McNerny, Erin M.B., Tantillo, Margaret A., Kohn, David H., Lyons, Karen M., Robey, Pamela G., Young, Marian F.

“…WISP1/CCN4 (hereafter referred to as WISP1), a member of the CCN family, is found in mineralized tissues and is produced by osteoblasts and their precursors…”
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Acidic Pre-Conditioning Enhances the Stem Cell Phenotype of Human Bone Marrow Stem/Progenitor Cells by Hazehara-Kunitomo, Yuri, Hara, Emilio Satoshi, Ono, Mitsuaki, Aung, Kyaw Thu, Komi, Keiko, Pham, Hai Thanh, Akiyama, Kentaro, Okada, Masahiro, Oohashi, Toshitaka, Matsumoto, Takuya, Kuboki, Takuo

“…A deeper understanding of the detailed mechanism of in vivo tissue healing is necessary for the development of novel regenerative therapies. Among several…”
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CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage by Kuwahara, Miho, Kadoya, Koichi, Kondo, Sei, Fu, Shanqi, Miyake, Yoshiko, Ogo, Ayako, Ono, Mitsuaki, Furumatsu, Takayuki, Nakata, Eiji, Sasaki, Takako, Minagi, Shogo, Takigawa, Masaharu, Kubota, Satoshi, Hattori, Takako

“…Aging is a major risk factor of osteoarthritis, which is characterized by the degeneration of articular cartilage. CCN3, a member of the CCN family, is…”
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WISP‐1/CCN4 regulates osteogenesis by enhancing BMP‐2 activity by Ono, Mitsuaki, Inkson, Colette A, Kilts, Tina M, Young, Marian F

“…Wnt‐induced secreted protein 1 (WISP‐1/CCN4) is a member of the CCN family that is highly expressed in skeletal tissue and in osteoprogenitor cells induced to…”
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Imatinib has minimal effects on inflammatory and osteopenic phenotypes in a murine cherubism model by Mukai, Tomoyuki, Akagi, Takahiko, Hiramatsu Asano, Sumie, Tosa, Ikue, Ono, Mitsuaki, Kittaka, Mizuho, Ueki, Yasuyoshi, Yahagi, Ayano, Iseki, Masanori, Oohashi, Toshitaka, Ishihara, Katsuhiko, Morita, Yoshitaka

“…Objective Cherubism is a genetic disorder characterised by bilateral jawbone deformation. The associated jawbone lesions regress after puberty, whereas severe…”
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Topical application of lithium chloride on the pulp induces dentin regeneration by Ishimoto, Kazuya, Hayano, Satoru, Yanagita, Takeshi, Kurosaka, Hiroshi, Kawanabe, Noriaki, Itoh, Shinsuke, Ono, Mitsuaki, Kuboki, Takuo, Kamioka, Hiroshi, Yamashiro, Takashi

“…We herein describe a novel procedure for dentin regeneration that mimics the biological processes of tooth development in nature. The canonical Wnt signaling…”
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Commensal Microbiota Enhance Both Osteoclast and Osteoblast Activities by Uchida, Yoko, Irie, Koichiro, Fukuhara, Daiki, Kataoka, Kota, Hattori, Takako, Ono, Mitsuaki, Ekuni, Daisuke, Kubota, Satoshi, Morita, Manabu

“…Recent studies suggest that the commensal microbiota affects not only host energy metabolism and development of immunity but also bone remodeling by positive…”
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Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model by Ono, Mitsuaki, Oshima, Masamitsu, Ogawa, Miho, Sonoyama, Wataru, Hara, Emilio Satoshi, Oida, Yasutaka, Shinkawa, Shigehiko, Nakajima, Ryu, Mine, Atsushi, Hayano, Satoru, Fukumoto, Satoshi, Kasugai, Shohei, Yamaguchi, Akira, Tsuji, Takashi, Kuboki, Takuo

“…Whole-organ regeneration has great potential for the replacement of dysfunctional organs through the reconstruction of a fully functional bioengineered organ…”
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Distinct Osteogenic Potentials of BMP-2 and FGF-2 in Extramedullary and Medullary Microenvironments by Nosho, Shuji, Tosa, Ikue, Ono, Mitsuaki, Hara, Emilio Satoshi, Ishibashi, Kei, Mikai, Akihiro, Tanaka, Yukie, Kimura-Ono, Aya, Komori, Taishi, Maekawa, Kenji, Kuboki, Takuo, Oohashi, Toshitaka

“…Bone morphogenetic protein-2 (BMP-2) and fibroblast growth factor-2 (FGF-2) have been regarded as the major cytokines promoting bone formation, however,…”
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Suppression of Bone Necrosis around Tooth Extraction Socket in a MRONJ-like Mouse Model by E-rhBMP-2 Containing Artificial Bone Graft Administration by Tanaka, Yukie, Aung, Kyaw Thu, Ono, Mitsuaki, Mikai, Akihiro, Dang, Anh Tuan, Hara, Emilio Satoshi, Tosa, Ikue, Ishibashi, Kei, Ono-Kimura, Aya, Nawachi, Kumiko, Kuboki, Takuo, Oohashi, Toshitaka

“…Medication-related osteonecrosis of the jaw (MRONJ) is related to impaired bone healing conditions in the maxillomandibular bone region as a complication of…”
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Preclinical bioequivalence study of E.coli-derived rhBMP-2/β-TCP and autogenous bone in a canine guided-bone regeneration model by Nosho, Shuji, Ono, Mitsuaki, Komori, Taishi, Mikai, Akihiro, Tosa, Ikue, Ishibashi, Kei, Tanaka, Yukie, Kimura-Ono, Aya, Hara, Emilio S, Oohashi, Toshitaka, Kuboki, Takuo

“…Bone morphogenetic protein (BMP)-2 is a potent growth factor that is widely used in the orthopedic and dental fields for bone regeneration. However,…”
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