Search Results - "ONO, MASAHIRO"

Restoring control over autoimmunity by inducing Foxp3 by Ono, Masahiro

“…Autoimmune inflammation and disease creates an environment that results in defective regulatory T (T reg ) cell functions. New data show how induction of Foxp3…”
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Unraveling T-cell dynamics using fluorescent timer: Insights from the Tocky system by Ono, Masahiro

“…Understanding the temporal dynamics of T-cell transcription is crucial for insights into immune cell function and development. In this study, we show the…”
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T-Cell Hyperactivation and Paralysis in Severe COVID-19 Infection Revealed by Single-Cell Analysis by Kalfaoglu, Bahire, Almeida-Santos, José, Tye, Chanidapa Adele, Satou, Yorifumi, Ono, Masahiro

“…Severe COVID-19 patients show various immunological abnormalities including T-cell reduction and cytokine release syndrome, which can be fatal and is a major…”
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Synthesis and Characterization of Novel Radioiodinated Triazole-Pyrolidine Derivative to Detect Orexin 2 Receptor in the Brain by Watanabe, Hiroyuki, Ide, Takuji, Ono, Masahiro

“…It is generally accepted that the orexin 2 receptor (OX2R) plays a critical role in the arousal-promoting function, and in vivo imaging of OX2R is expected to…”
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Fundamental evaluation regarding the relationship between albumin-binding and tumor accumulation of PSMA-targeting radioligands by Kazuta, Nobuki, Tsuchihashi, Shohei, Watanabe, Hiroyuki, Ono, Masahiro

“…Objective The marked success of prostate-specific membrane antigen (PSMA)-targeting radioligands with albumin binder (ALB) is attributed to the improvement of…”
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Novel technetium-99m-labeled bivalent PSMA-targeting probe based on hydroxamamide chelate for diagnosis of prostate cancer by Shimizu, Yoichi, Ando, Masato, Watanabe, Hiroyuki, Ono, Masahiro

“…Objective Prostate-specific membrane antigen (PSMA) is a well-known biomarker of prostate cancer. Previously, our group reported that the…”
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Development of a hydroxamamide-based bifunctional chelating agent to prepare technetium-99m-labeled bivalent ligand probes by Shimizu, Yoichi, Ando, Masato, Iikuni, Shimpei, Watanabe, Hiroyuki, Ono, Masahiro

“…Hydroxamamide (Ham) is a thiol-free chelating agent that forms technetium-99m ( 99m Tc)-complexes with a metal-to-ligand ratio of 1:2 under moderate reaction…”
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EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight junction barrier by Higashi, Tomohito, Saito, Akira C, Fukazawa, Yugo, Furuse, Mikio, Higashi, Atsuko Y, Ono, Masahiro, Chiba, Hideki

“…TJs maintain the epithelial barrier by regulating paracellular permeability. Since TJs are under dynamically fluctuating intercellular tension, cells must…”
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Optimal blood pressure during cardiopulmonary bypass defined by cerebral autoregulation monitoring by Hori, Daijiro, Nomura, Yohei, Ono, Masahiro, Joshi, Brijen, Mandal, Kaushik, Cameron, Duke, Kocherginsky, Masha, Hogue, Charles W.

“…We sought to define the lower and upper limits of cerebral blood flow autoregulation and the optimal blood pressure during cardiopulmonary bypass. We further…”
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Synthesis and evaluation of indium-111-labeled imidazothiadiazole sulfonamide derivative for single photon emission computed tomography imaging targeting carbonic anhydrase-IX by Iikuni, Shimpei, Okada, Yuya, Shimizu, Yoichi, Watanabe, Hiroyuki, Ono, Masahiro

“…[Display omitted] •An 111In-labeled imidazothiadiazole sulfonamide ([111In]DO3A-IS1) was synthesized.•[111In]DO3A-IS1 exhibited selective binding to CA-IX…”
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PET imaging and pharmacological therapy targeting carbonic anhydrase-IX high-expressing tumors using US2 platform based on bivalent ureidosulfonamide by Iikuni, Shimpei, Watanabe, Hiroyuki, Shimizu, Yoichi, Nakamoto, Yuji, Ono, Masahiro

“…Carbonic anhydrase-IX (CA-IX) is attracting much attention as a target molecule for cancer treatment since high expression of CA-IX can lead to a poor…”
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A Probabilistic Particle-Control Approximation of Chance-Constrained Stochastic Predictive Control by Blackmore, Lars, Ono, Masahiro, Bektassov, Askar, Williams, Brian C

“…Robotic systems need to be able to plan control actions that are robust to the inherent uncertainty in the real world. This uncertainty arises due to uncertain…”
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Scalable information-theoretic path planning for a rover-helicopter team in uncertain environments by Folsom, Larkin, Ono, Masahiro, Otsu, Kyohei, Park, Hyoshin

“…Mission-critical exploration of uncertain environments requires reliable and robust mechanisms for achieving information gain. Typical measures of information…”
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Development of Positron-Emission Tomography/Single-Photon Emission Computed Tomography Imaging Probes for in Vivo Detection of β-Amyloid Plaques in Alzheimer's Brains by Ono, Masahiro

“…Currently, the development of radiotracers for in vivo imaging of β-amyloid plaques in Alzheimer's disease (AD) brains is an important, active area of…”
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Highly efficient crystalline silicon/Zonyl fluorosurfactant-treated organic heterojunction solar cells by Liu, Qiming, Ono, Masahiro, Tang, Zeguo, Ishikawa, Ryo, Ueno, Keiji, Shirai, Hajime

“…We demonstrate a highly efficient hybrid crystalline silicon (c-Si) based photovoltaic devices with hole-transporting transparent conductive…”
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Synthesis and evaluation of novel technetium-99m-hydroxamamide complex based on imidazothiadiazole sulfonamide targeting carbonic anhydrase-IX for tumor imaging by Iikuni, Shimpei, Kitano, Anna, Watanabe, Hiroyuki, Shimizu, Yoichi, Ono, Masahiro

“…[Display omitted] •A [99mTc]hydroxamamide complex for CA-IX imaging ([99mTc]ISB2) was designed.•[99mTc]ISB2 was easily synthesized from the precursor at room…”
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A timer for analyzing temporally dynamic changes in transcription during differentiation in vivo by Bending, David, Prieto Martín, Paz, Paduraru, Alina, Ducker, Catherine, Marzaganov, Erik, Laviron, Marie, Kitano, Satsuki, Miyachi, Hitoshi, Crompton, Tessa, Ono, Masahiro

“…Understanding the mechanisms of cellular differentiation is challenging because differentiation is initiated by signaling pathways that drive temporally…”
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Nr4a1 and Nr4a3 Reporter Mice Are Differentially Sensitive to T Cell Receptor Signal Strength and Duration by Jennings, Emma, Elliot, Thomas A.E., Thawait, Natasha, Kanabar, Shivani, Yam-Puc, Juan Carlos, Ono, Masahiro, Toellner, Kai-Michael, Wraith, David C., Anderson, Graham, Bending, David

“…Nr4a receptors are activated by T cell receptor (TCR) signaling and play key roles in T cell differentiation. Which TCR signaling pathways regulate Nr4a…”
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Predicting the Limits of Cerebral Autoregulation During Cardiopulmonary Bypass by Joshi, Brijen, Ono, Masahiro, Brown, Charles, Brady, Kenneth, Easley, R. Blaine, Yenokyan, Gayane, Gottesman, Rebecca F., Hogue, Charles W.

“…Mean arterial blood pressure (MAP) targets are empirically chosen during cardiopulmonary bypass (CPB). We have previously shown that near-infrared spectroscopy…”
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Duration and magnitude of blood pressure below cerebral autoregulation threshold during cardiopulmonary bypass is associated with major morbidity and operative mortality by Ono, Masahiro, MD, PhD, Brady, Kenneth, MD, Easley, R. Blaine, MD, Brown, Charles, MD, Kraut, Michael, MD, PhD, Gottesman, Rebecca F., MD, PhD, Hogue, Charles W., MD

“…Objectives Optimizing blood pressure using near-infrared spectroscopy monitoring has been suggested to ensure organ perfusion during cardiac surgery…”
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