Gastric tissue oxidative changes in portal hypertension and cirrhosis

Gastric mucosal lesions are very common in portal hypertension and cirrhosis. The aim of this study was to assess for oxidative gastric tissue damage in cirrhosis and evaluate relations with portal hypertension and cirrhosis parameters. The study included 30 patients with cirrhosis and 30 controls....

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Bibliographic Details
Published in:	Digestive diseases and sciences Vol. 52; no. 5; pp. 1154 - 1158
Main Authors:	SECKIN, Yuksel, HARPUTLUOGLU, Murat M. M, BATCIOGLU, Kadir, KARINCAOGLU, Melih, YILDIRIM, Bulent, ONER, Ramazan I, UYUMLU, Burcin, AYDOGDU, Nurettin, HILMIOGLU, Fatih
Format:	Journal Article
Language:	English
Published:	Heidelberg Springer 01-05-2007 Springer Nature B.V
Subjects:	Adult Aged Biochemistry Biological and medical sciences Biopsy Case-Control Studies Catalase - metabolism Endoscopy Enzymes Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastric Mucosa - enzymology Gastric Mucosa - metabolism Gastric Mucosa - microbiology Gastric Mucosa - pathology Gastroenterology. Liver. Pancreas. Abdomen Gastroscopy Glutathione Peroxidase - metabolism Helicobacter pylori - isolation & purification Hepatitis Humans Hypertension Hypertension, Portal - enzymology Hypertension, Portal - metabolism Hypertension, Portal - microbiology Hypertension, Portal - pathology Infections Liver cirrhosis Liver Cirrhosis - enzymology Liver Cirrhosis - metabolism Liver Cirrhosis - microbiology Liver Cirrhosis - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Malondialdehyde - metabolism Medical sciences Middle Aged Other diseases. Semiology Oxidative Stress Patients Portal Vein - pathology Prospective Studies Proteins Spleen - pathology Superoxide Dismutase - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems Spleen Stomach Oxygen Portal circulation disease Mucosa Cardiovascular disease Hepatic disease Metabolic diseases Oxidative Antioxidant Hemorrhage Stress Vascular disease Cirrhosis Reactive oxygen species; Antioxidant enzyme Biopsy Gastroenterology Portal hypertension Digestive diseases Endoscopy Portal vein Cirrhosis, Portal hypertension; Stress
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Summary:	Gastric mucosal lesions are very common in portal hypertension and cirrhosis. The aim of this study was to assess for oxidative gastric tissue damage in cirrhosis and evaluate relations with portal hypertension and cirrhosis parameters. The study included 30 patients with cirrhosis and 30 controls. Each patient's history, physical examination, and laboratory findings were recorded, and multiple biopsies of the gastric antrum were obtained at endoscopy. A set of antral biopsies was also collected from each control subject. Each tissue specimen was analyzed for levels of glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase (CAT) activity and level of malondialdehyde (MDA). Patients' gastric GPX, SOD, and CAT levels were significantly lower, and MDA levels were higher, than in the control group. The GPX activity level in the specimens was moderately negatively correlated with portal vein diameter (P<0.05, r=-0.45) and spleen length (P<0.05, r=-0.45). In this study gastric tissue oxidative markers showed that antral oxidative factors worsen in cirrhosis. Oxidative stress may not be a clinical condition but it obviously shows gastric tissue damage and may explain many patients' gastric lesions and hemorrhage.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	0163-2116 1573-2568
DOI:	10.1007/s10620-006-9139-8