Search Results - "ONAY, TUNCER"

Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies by Thomson, Benjamin R., Liu, Pan, Onay, Tuncer, Du, Jing, Tompson, Stuart W., Misener, Sol, Purohit, Raj R., Young, Terri L., Jin, Jing, Quaggin, Susan E.

“…Primary congenital glaucoma (PCG) is a severe disease characterized by developmental defects in the trabecular meshwork (TM) and Schlemm’s canal (SC),…”
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Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP by Souma, Tomokazu, Thomson, Benjamin R., Heinen, Stefan, Carota, Isabel Anna, Yamaguchi, Shinji, Onay, Tuncer, Liu, Pan, Ghosh, Asish K., Li, Chengjin, Eremina, Vera, Hong, Young-Kwon, Economides, Aris N., Vestweber, Dietmar, Peters, Kevin G., Jin, Jing, Quaggin, Susan E.

“…The angiopoietin (ANGPT)–TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas…”
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Inhibition of MTOR Disrupts Autophagic Flux in Podocytes by CINA, Davide P, ONAY, Tuncer, PALTOO, Aarti, CHENGJIN LI, MAEZAWA, Yoshiro, DE ARTEAGA, Javier, JURISICOVA, Andrea, QUAGGIN, Susan E

“…Inhibitors of the mammalian target of rapamycin (MTOR) belong to a family of drugs with potent immunosuppressive, antiangiogenic, and antiproliferative…”
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Ascending Vasa Recta Are Angiopoietin/Tie2-Dependent Lymphatic-Like Vessels by Kenig-Kozlovsky, Yael, Scott, Rizaldy P, Onay, Tuncer, Carota, Isabel Anna, Thomson, Benjamin R, Gil, Hyea Jin, Ramirez, Veronica, Yamaguchi, Shinji, Tanna, Christine E, Heinen, Stefan, Wu, Christine, Stan, Radu V, Klein, Janet D, Sands, Jeff M, Oliver, Guillermo, Quaggin, Susan E

“…Urinary concentrating ability is central to mammalian water balance and depends on a medullary osmotic gradient generated by a countercurrent multiplication…”
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Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development by Ide, Shintaro, Finer, Gal, Maezawa, Yoshiro, Onay, Tuncer, Souma, Tomokazu, Scott, Rizaldy, Ide, Kana, Akimoto, Yoshihiro, Li, Chengjin, Ye, Minghao, Zhao, Xiangmin, Baba, Yusuke, Minamizuka, Takuya, Jin, Jing, Takemoto, Minoru, Yokote, Koutaro, Quaggin, Susan E

“…The mammalian kidney develops through reciprocal inductive signals between the metanephric mesenchyme and ureteric bud. Transcription factor 21 (Tcf21) is…”
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Targeting VE-PTP phosphatase protects the kidney from diabetic injury by Carota, Isabel A, Kenig-Kozlovsky, Yael, Onay, Tuncer, Scott, Rizaldy, Thomson, Benjamin R, Souma, Tomokazu, Bartlett, Christina S, Li, Yanyang, Procissi, Daniele, Ramirez, Veronica, Yamaguchi, Shinji, Tarjus, Antoine, Tanna, Christine E, Li, Chengjin, Eremina, Vera, Vestweber, Dietmar, Oladipupo, Sunday S, Breyer, Matthew D, Quaggin, Susan E

“…Diabetic nephropathy is a leading cause of end-stage kidney failure. Reduced angiopoietin-TIE2 receptor tyrosine kinase signaling in the vasculature leads to…”
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Loss of the podocyte-expressed transcription factor Tcf21/Pod1 results in podocyte differentiation defects and FSGS by Maezawa, Yoshiro, Onay, Tuncer, Scott, Rizaldy P, Keir, Lindsay S, Dimke, Henrik, Li, Chengjin, Eremina, Vera, Maezawa, Yuko, Jeansson, Marie, Shan, Jingdong, Binnie, Matthew, Lewin, Moshe, Ghosh, Asish, Miner, Jeffrey H, Vainio, Seppo J, Quaggin, Susan E

“…Podocytes are terminally differentiated cells with an elaborate cytoskeleton and are critical components of the glomerular barrier. We identified a bHLH…”
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Duplication of GTF2I Results in Separation Anxiety in Mice and Humans by Mervis, Carolyn B., Dida, Joana, Lam, Emily, Crawford-Zelli, Nicole A., Young, Edwin J., Henderson, Danielle R., Onay, Tuncer, Morris, Colleen A., Woodruff-Borden, Janet, Yeomans, John, Osborne, Lucy R.

“…Duplication (dup7q11.23) and deletion (Williams syndrome) of chromosomal region 7q11.23 cause neurodevelopmental disorders with contrasting anxiety phenotypes…”
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Ectopic Notch Activation in Developing Podocytes Causes Glomerulosclerosis by WATERS, Aoife M, WU, Megan Y. J, ONAY, Tuncer, SCUTARU, Jacob, JU LIU, LOBE, Corrinne G, QUAGGIN, Susan E, PISCIONE, Tino D

“…Genetic evidence supports an early role for Notch signaling in the fate of podocytes during glomerular development. Decreased expression of Notch…”
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Genetic Deletion of Emp2 Does Not Cause Proteinuric Kidney Disease in Mice by Donnan, Michael D, Scott, Rizaldy P, Onay, Tuncer, Tarjus, Antoine, Onay, Ummiye Venus, Quaggin, Susan E

“…Nephrotic syndrome is one of the most common glomerular diseases in children and can be classified on the basis of steroid responsiveness. While multiple…”
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MTOR regulates autophagic flux in the glomerulus by Cinà, Davide P., Onay, Tuncer, Paltoo, Aarti, Li, Chengjin, Maezawa, Yoshiro, De Arteaga, Javier, Jurisicova, Andrea, Quaggin, Susan E.

“…Sirolimus (rapamycin), an inhibitor of the mechanistic target of rapamycin (MTOR), was originally proposed as an immunosuppressant to prevent rejection of…”
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Endothelial Tyrosine Kinase Tie1 Is Required for Normal Schlemm’s Canal Development—Brief Report by Du, Jing, Thomson, Benjamin R., Onay, Tuncer, Quaggin, Susan E.

“…Schlemm's canal (SC) is a large vessel residing in the iridocorneal angle and is required to regulate aqueous humor outflow. Normal SC structure and function…”
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Endothelial Tyrosine Kinase Tie1 Is Required for Normal Schlemm’s Canal Development by Du, Jing, Thomson, Benjamin R., Onay, Tuncer, Quaggin, Susan E.

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Targeting Angiopoietin-Tie2 Signaling in Kidney Ischemia-Reperfusion Injury: SU-OR06 by Li, Yanyang, Onay, Tuncer, Liu, Pan, Ryczko, Michael, Ansari, Mohammed Javeed, Jin, Jing, Quaggin, Susan E.

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Vegfr3 Is Expressed in Fenestrated Microvascular Beds of the Kidney and Is Required for Glomerular Development: PO0888 by Donnan, Michael D., Onay, Tuncer, Scott, Rizaldy P., Thomas, Jean-Leon, Quaggin, Susan E.

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Mechanisms of VEGFR3 Signaling in Glomerular Development: PO0614 by Donnan, Michael D., Onay, Tuncer, Scott, Rizaldy P., Deb, Dilip K., Thomas, Jean-Leon, Quaggin, Susan E.

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Stromal Transcription Factor 21 Is Critical for Development of the Interstitium and Nephron Progenitor Cells via Interaction with Wnt/β-Catenin Signaling: PO0610 by Finer, Gal, Maezawa, Yoshiro, Ide, Shintaro, Onay, Tuncer, Souma, Tomokazu, Winter, Deborah R., Quaggin, Susan E., Hayashida, Tomoko

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Glaucoma-Protective Human Single-Nucleotide Polymorphism in the Angpt2 Locus Increased ANGPT2 Expression and Schlemm Canal Area in Mice-Brief Report by Kiyota, Naoki, Onay, Tuncer, Leeaw, Phoebe, Liu, Pan, Deb, Dilip K, Thomson, Benjamin R, Segrè, Ayellet V, Wiggs, Janey L, Quaggin, Susan E

“…The ANGPT (angiopoietin)-TEK (tyrosine kinase, endothelial) vascular signaling pathway plays a key role in the formation of Schlemm canal, and loss-of-function…”
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A lymphatic defect causes ocular hypertension and glaucoma in mice by Thomson, Benjamin R, Heinen, Stefan, Jeansson, Marie, Ghosh, Asish K, Fatima, Anees, Sung, Hoon-Ki, Onay, Tuncer, Chen, Hui, Yamaguchi, Shinji, Economides, Aris N, Flenniken, Ann, Gale, Nicholas W, Hong, Young-Kwon, Fawzi, Amani, Liu, Xiaorong, Kume, Tsutomu, Quaggin, Susan E

“…Glaucoma is a leading cause of blindness, afflicting more than 60 million people worldwide. Increased intraocular pressure (IOP) due to impaired aqueous humor…”
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Primary cilia TRP channel regulates hippocampal excitability by Vien, Thuy N, Ta, My C, Kimura, Louise F, Onay, Tuncer, DeCaen, Paul G

“…Polycystins (PKD2, PKD2L1, and PKD2L2) are members of the transient receptor potential family, which form ciliary ion channels. Most notably, PKD2…”
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