Search Results - "OMURA, KOICHI"

Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2 by Taniguchi, Tetsuya, Omura, Koichi, Motoki, Keisuke, Sakai, Miku, Chikamatsu, Noriko, Ashizawa, Naoki, Takada, Tappei, Iwanaga, Takashi

“…Indoxyl sulfate (IS) accumulates in the body in chronic kidney disease (CKD). In the renal proximal tubules, IS excretion is mediated by OAT1/3 and ABCG2…”
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Ideal pharmacokinetic profile of dotinurad as a selective urate reabsorption inhibitor by Omura, Koichi, Miyata, Kengo, Kobashi, Seiichi, Ito, Azusa, Fushimi, Masahiko, Uda, Junichiro, Sasaki, Tomomitsu, Iwanaga, Takashi, Ohashi, Tetsuo

“…Dotinurad, a novel selective urate reabsorption inhibitor (SURI), has potent inhibitory effects at low doses on the uptake of urate by urate transporter 1…”
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Pharmacokinetic/pharmacodynamic modeling and simulation of dotinurad, a novel uricosuric agent, in healthy volunteers by Motoki, Keisuke, Igarashi, Takako, Omura, Koichi, Nakatani, Hiroshi, Iwanaga, Takashi, Tamai, Ikumi, Ohashi, Tetsuo

“…This study aimed to investigate the pharmacokinetic and pharmacodynamic (PK/PD) profiles of dotinurad, a novel uricosuric agent, and to construct a PK/PD model…”
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Metabolic Profile of FYX-051 (4-(5-Pyridin-4-yl-1H-[1,2,4]triazol-3-yl)pyridine-2-carbonitrile) in the Rat, Dog, Monkey, and Human: Identification of N-Glucuronides and N-Glucosides by Nakazawa, Takashi, Miyata, Kengo, Omura, Koichi, Iwanaga, Takashi, Nagata, Osamu

“…FYX-051, 4-(5-pyridin-4-yl-1 H -[1,2,4]triazol-3-yl)pyridine-2-carbonitrile, is a novel xanthine oxidoreductase inhibitor that can be used for the treatment of…”
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Characterization of N-Glucuronidation of 4-(5-Pyridin-4-yl-1H-[1,2,4]triazol-3-yl) pyridine-2-carbonitrile (FYX-051): A New Xanthine Oxidoreductase Inhibitor by OMURA, Koichi, NAKAZAWA, Takashi, SATO, Takahiro, IWANAGA, Takashi, NAGATA, Osamu

“…In humans, orally administered 4-(5-pyridin-4-yl-1 H -[1,2,4]triazol-3-yl) pyridine-2-carbonitrile (FYX-051) is excreted mainly as triazole N 1 - and N 2…”
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Identification of Human UDP-Glucuronosyltransferase and Sulfotransferase as Responsible for the Metabolism of Dotinurad, a Novel Selective Urate Reabsorption Inhibitor by Omura, Koichi, Motoki, Keisuke, Kobashi, Seiichi, Miyata, Kengo, Yamano, Katsuhiro, Iwanaga, Takashi

“…Dotinurad, a novel selective urate reabsorption inhibitor, is used to treat hyperuricemia. In humans, orally administered dotinurad is excreted mainly as…”
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Metabolic profile of FYX-051 (4-(5-pyridin-4-yl-1h-[1,2,4]triazol-3-yl)pyridine-2-carbonitrile) Hn the rat, dog, monkey, and human : Identification of N-glucuronides and N-glucosides by NAKAZAWA, Takashi, MIYATA, Kengo, OMURA, Koichi, IWANAGA, Takashi, NAGATA, Osamu

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An approach to the dental CAD/CAM (Part 4). Fundamental CAD procedure for the data base by Kimura, H, Kawanaka, M, Watanabe, T, Takahashi, J, Omura, K, An, H

“…Studies are currently underway to apply the CAD/CAM system to dentistry and to make prosthetic appliances automatically. This paper reports the basic CAD…”
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An approach to dental CAD/CAM (Part 2). Measurement with 3D point digitizer and Spline interpolation by Kimura, H, Kawanaka, M, Watanabe, T, Takahashi, J, Omura, K, An, H

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An approach to the dental CAD/CAM. (Part 3). The CAD data base by Kimura, H, Kawanaka, M, Watanabe, T, Takahashi, J, Omura, K, An, H

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Generating artificially mastered motions for an upper limb in baseball pitching from several objective functions by Mochizuki, Y., Inokuchi, S., Omura, K.

“…It is possible to consider a mastered skill to be an optimal skill under some conditions, especially in the field of sports, We call an ideal skill generated…”
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THE CLINICAL EFFECT OF VISTAMYCIN IN URINARY TRACT INFECTIONS by KUMAZAWA, JYOICHI, MOMOSE, SHUNRO, HIRATA, Kozo, HIDAKA, MASAAKI, OTA, YASUHIRO, UEDA, TOYOHUMI, ISHIZU, YOSHIKAZU, ARIYOSHI, ASAMI, NARAHASHI, KATSUTOSHI, YOKOYAMA, JYOJI, NAGAYOSHI, HIROYUKI, NAKAYAMA, HIROSHI, IWATSUBO, EIJI, OMURA, KOICHI, KIYOHARA, HIROHIKO, AITO, KENJI, FUJISAWA, YASUHITO, HIRATA, HIROSHI, OSADA, YUKIO

“…Ninety-eight patients with various urinary tract infections were treated with Vistamycin at the Department of Urology, Kyushu University, and other 10…”
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A new method for three-dimensional reconstruction from serial sections by computer graphics using "meta-balls": reconstruction of "hepatoskeletal system" formed by Ito cells in the cod liver by Tatsumi, H, Takaoki, E, Omura, K, Fujita, H

“…A new method is described for three-dimensional reconstruction from serial ultrathin sections, using "meta-balls" as a primitive of object modeling in computer…”
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A study on dynamic design and applications of a tunnel-diode-transistor combined circuit by Okamoto, T., Misaki, T., Omura, K., Kitamura, Z.

“…The dynamic design of the tunnel-diode-transistor combined circuit, in which a tunnel diode is connected in parallel with the collector junction of a…”
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