Search Results - "OLSEN, R. W"

Ethanol enhances α4β3δ and α6β3δ γ-aminobutyric acid type A receptors at low concentrations known to affect humans by Wallner, M., Hanchar, H. J., Olsen, R. W.

“…γ-Aminobutyric acid type A receptors (GABARs) have long been implicated in mediating ethanol (EtOH) actions, but so far most of the reported recombinant GABAR…”
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Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development? by Wallner, M, Olsen, R W

“…Alcohol (ethanol, EtOH) has pleiotropic actions and induces a number of acute and long‐term effects due to direct actions on alcohol targets, and effects of…”
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GABA and Epileptogenesis by Olsen, Richard W., Avoli, Massimo

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Alcohol Selectivity of β3-Containing GABAA Receptors: Evidence for a Unique Extracellular Alcohol/Imidazobenzodiazepine Ro15-4513 Binding Site at the α+β- Subunit Interface in αβ3δ GABAA Receptors by Wallner, M., Hanchar, H. J., Olsen, R. W.

“…GABA A receptors (GABARs) have long been the focus for acute alcohol actions with evidence for behaviorally relevant low millimolar alcohol actions on tonic…”
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Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABA A receptors as an opportunity for drug development? by Wallner, M, Olsen, R W

“…Alcohol (ethanol, EtOH) has pleiotropic actions and induces a number of acute and long‐term effects due to direct actions on alcohol targets, and effects of…”
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Low-dose alcohol actions on α4β3δ GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513 by Wallner, M., Hanchar, H. J., Olsen, R. W.

“…Although it is now more than two decades since it was first reported that the imidazobenzodiazepine Ro15-4513 reverses behavioral alcohol effects, the…”
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GABAA receptor α4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol by Chandra, D., Jia, F., Liang, J., Peng, Z., Suryanarayanan, A., Werner, D. F., Spigelman, I., Houser, C. R., Olsen, R. W., Harrison, N. L., Homanics, G. E.

“…The neurotransmitter GABA mediates the majority of rapid inhibition in the CNS. Inhibition can occur via the conventional mechanism, the transient activation…”
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Basis of the Gabamimetic Profile of Ethanol by Breese, G. R., Criswell, H. E., Carta, M., Dodson, P. D., Hanchar, H. J., Khisti, R. T., Mameli, M., Ming, Z., Morrow, A. L., Olsen, R. W., Otis, T. S., Parsons, L. H., Penland, S. N., Roberto, M., Siggins, G. R., Valenzuela, C. F., Wallner, M.

“…This article summarizes the proceedings of a symposium held at the 2005 Research Society on Alcoholism meeting. The initial presentation by Dr. Wallner…”
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Molecular biology of GABAA receptors by Olsen, R W, Tobin, A J

“…The major type of receptor for the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), called the GABAA receptor, is a member of a gene superfamily of…”
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Absinthe and γ -aminobutyric Acid Receptors by Olsen, Richard W.

“…The most likely ingredient in absinthe responsible for toxicity is believed to be the terpenoid alpha-thujone. A recent study provided evidence that thujone…”
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Identification of a [3H]muscimol photoaffinity substrate in the bovine gamma-aminobutyric acidA receptor alpha subunit by SMITH, G. B, OLSEN, R. W

“…An amino acid which appears to be involved in an agonist binding site of the gamma-aminobutyric acid type A (GABAA) receptor protein has been identified by…”
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Angelman syndrome: correlations between epilepsy phenotypes and genotypes by Minassian, B A, DeLorey, T M, Olsen, R W, Philippart, M, Bronstein, Y, Zhang, Q, Guerrini, R, Van Ness, P, Livet, M O, Delgado-Escueta, A V

“…We compared epilepsy phenotypes with genotypes of Angelman syndrome (AS), including chromosome 15q11-13 deletions (class I), uniparental disomy (class II),…”
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Steroid anesthetics and naturally occurring analogs modulate the gamma-aminobutyric acid receptor complex at a site distinct from barbiturates by Turner, D M, Ransom, R W, Yang, J S, Olsen, R W

“…The steroid anesthetic alphaxalone and a series of naturally occurring analogs were compared in potency and efficacy with each other and the hypnotic…”
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GABAA receptor channels by MACDONALD, R. L, OLSEN, R. W

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Trace and contextual fear conditioning is enhanced in mice lacking the α4 subunit of the GABAA receptor by MOORE, M. D, CUSHMAN, J, CHANDRA, D, HOMANICS, G. E, OLSEN, R. W, FANSELOW, M. S

“…The GABA A R α4 subunit is highly expressed in the dentate gyrus region of the hippocampus at predominantly extra-synaptic locations where, along with the GABA…”
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Drug interactions at the GABA receptor-ionophore complex by Olsen, R W

“…A review…”
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Multiple distinct subunits of the gamma-aminobutyric acid-A receptor protein show different ligand-binding affinities by Bureau, M, Olsen, R W

“…The purified gamma-aminobutyric acid/benzodiazepine receptor protein from mammalian brain contains at least four discrete polypeptides (Mr 51,000, 53,000,…”
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Immortalized hypothalamic GT1-7 neurons express functional gamma-aminobutyric acid type A receptors by Hales, T G, Kim, H, Longoni, B, Olsen, R W, Tobin, A J

“…Neuronal cell lines provide a source of pure populations of neurons and allow the properties of many neurotransmitter receptors to be studied. However, none of…”
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The kindling model of alcohol dependence: similar persistent reduction in seizure threshold to pentylenetetrazol in animals receiving chronic ethanol or chronic pentylenetetrazol by Kokka, N, Sapp, D W, Taylor, A M, Olsen, R W

“…Rats on a chronic intermittent ethanol (CIE) regimen showed a persistent reduction in seizure threshold to the convulsant drug pentylenetetrazol (PTZ). CIE…”
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Compensation and trapping in CdZnTe radiation detectors studied by thermoelectric emission spectroscopy, thermally stimulated conductivity, and current-voltage measurements by Lee, E. Y., James, R. B., Olsen, R. W., Hermon, H.

“…The thermal ionization energies of traps and their types, whether electron or hole traps, were measured in commercial CdZnTe crystals for radiation detectors…”
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