Search Results - "OLSEN, GRITH S."

Receptor-isoform-selective insulin analogues give tissue-preferential effects by Vienberg, Sara G, Bouman, Stephan D, Sørensen, Heidi, Stidsen, Carsten E, Kjeldsen, Thomas, Glendorf, Tine, Sørensen, Anders R, Olsen, Grith S, Andersen, Birgitte, Nishimura, Erica

“…The relative expression patterns of the two IR (insulin receptor) isoforms, +/- exon 11 (IR-B/IR-A respectively), are tissue-dependent. Therefore we have…”
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802-P: Beneficial Effects of a Functionally Selective Insulin on Vascular Function and Liver Triglycerides by OLSEN, GRITH S., PEDERSEN, THOMAS A., SLAABY, RITA, HANSEN, BO F., GLENDORF, TINE, DEMOZAY, DAMIEN, HVID, HENNING, NISHIMURA, ERICA, BRANDT, JAKOB, POVLEN, GRO

“…Selective insulin resistance, where insulin's ability to lower blood glucose via the Akt signaling pathway gradually decreases while retaining its…”
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A Novel Strategy to Prevent Advanced Atherosclerosis and Lower Blood Glucose in a Mouse Model of Metabolic Syndrome by Kanter, Jenny E, Kramer, Farah, Barnhart, Shelley, Duggan, Jeffrey M, Shimizu-Albergine, Masami, Kothari, Vishal, Chait, Alan, Bouman, Stephan D, Hamerman, Jessica A, Hansen, Bo F, Olsen, Grith S, Bornfeldt, Karin E

“…Cardiovascular disease caused by atherosclerosis is the leading cause of mortality associated with type 2 diabetes and metabolic syndrome. Insulin therapy is…”
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Preclinical exploration of combined glucagon inhibition and liver-preferential insulin for treatment of diabetes using in vitro assays and rat and mouse models by Hvid, Henning, Brand, Christian L., Hummelshøj, Tina, Jensen, Sanne, Bouman, Stephan D., Bowler, Andrew, Poulsen, Bjarne R., Tiainen, Peter, Åkertröm, Thorbjörn, Demozay, Damien, Hoeg-Jensen, Thomas, Ingvorsen, Camilla, Pedersen, Thomas Å., McGuire, Jim, Egebjerg, Thomas, Cappelen, Karen A., Eliasen, Ina P., Hansen, Bo F., Hennen, Stephanie, Stidsen, Carsten E., Olsen, Grith S., Roed, Nikolaj K.

“…Aims/hypothesis Normalisation of blood glucose in individuals with diabetes is recommended to reduce development of diabetic complications. However, risk of…”
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Treatment of diabetic rats with insulin or a synthetic insulin receptor agonist peptide leads to divergent metabolic responses by Frikke-Schmidt, Henriette, Pedersen, Thomas Å, Fledelius, Christian, Olsen, Grith S, Bouman, Stephan D, Fitch, Mark, Hellerstein, Marc

“…In addition to lowering of blood glucose, treatment with insulin also induces lipid synthesis and storage. Patients with type 2 diabetes often suffer from…”
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AMP kinase activation ameliorates insulin resistance induced by free fatty acids in rat skeletal muscle by Olsen, Grith S, Hansen, Bo F

“…We examined whether acute activation of 5'-AMP-activated protein kinase (AMPK) by 5'-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside (AICAR) ameliorates…”
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Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus: Overexpression of protein kinase Cε in skeletal muscle precedes the onset of hyperinsulinemia and hyperglycemia by IKEDA, Yukio, OLSEN, Grith S, ZIV, Ehud, HANSEN, Lone L, BUSCH, Anna K, HANSEN, Bo F, SHAFRIR, Eleazar, MOSTHAF-SEEDORF, Luitgard

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Identification and Synthesis of a Novel Selective Partial PPARδ Agonist with Full Efficacy on Lipid Metabolism In Vitro and In Vivo by Sauerberg, Per, Olsen, Grith S, Jeppesen, Lone, Mogensen, John P, Pettersson, Ingrid, Jeppesen, Claus B, Daugaard, Jens R, Galsgaard, Elisabeth D, Ynddal, Lars, Fleckner, Jan, Panajotova, Vladimira, Polivka, Zdenek, Pihera, Pavel, Havranek, Miroslav, Wulff, Erik M

“…The aim was to identify a novel selective PPARδ agonist with full efficacy on free fatty acid (FFA) oxidation in vitro and plasma lipid correction in vivo…”
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Design of potent PPARα agonists by Sauerberg, Per, Mogensen, John P., Jeppesen, Lone, Bury, Paul S., Fleckner, Jan, Olsen, Grith S., Jeppesen, Claus B., Wulff, Erik M., Pihera, Pavel, Havranek, Miroslav, Polivka, Zdenek, Pettersson, Ingrid

“…Computational analysis of the ligand binding pocket of the three PPAR receptor subtypes was utilized in the design of potent PPARα agonists. Optimum PPARα…”
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Cellular Mechanism of Nutritionally Induced Insulin Resistance in Psammomys Obesus by Ikeda, Yukio, Olsen, Grith S., Ziv, Ehud, Hansen, Lone L., Busch, Anna K., Hansen, Bo F., Shafrir, Eleazar, Mosthaf-Seedorf, Luitgard

“…Cellular Mechanism of Nutritionally Induced Insulin Resistance in Psammomys Obesus Overexpression of Protein Kinase Cε in Skeletal Muscle Precedes the Onset of…”
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Insulin Signaling Is Inhibited by Micromolar Concentrations of H2O2 by Hansen, Lone L., Ikeda, Yukio, Olsen, Grith S., Busch, Anna K., Mosthaf, Luitgard

“…Both hyperglycemia and tumor necrosis factor α (TNFα) were found to induce insulin resistance at the level of the insulin receptor (IR). How this effect is…”
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Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo by Sauerberg, Per, Olsen, Grith S, Jeppesen, Lone, Mogensen, John P, Pettersson, Ingrid, Jeppesen, Claus B, Daugaard, Jens R, Galsgaard, Elisabeth D, Ynddal, Lars, Fleckner, Jan, Panajotova, Vladimira, Polivka, Zdenek, Pihera, Pavel, Havranek, Miroslav, Wulff, Erik M

“…The aim was to identify a novel selective PPARdelta agonist with full efficacy on free fatty acid (FFA) oxidation in vitro and plasma lipid correction in vivo…”
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Design of potent PPARalpha agonists by Sauerberg, Per, Mogensen, John P, Jeppesen, Lone, Bury, Paul S, Fleckner, Jan, Olsen, Grith S, Jeppesen, Claus B, Wulff, Erik M, Pihera, Pavel, Havranek, Miroslav, Polivka, Zdenek, Pettersson, Ingrid

“…Computational analysis of the ligand binding pocket of the three PPAR receptor subtypes was utilized in the design of potent PPARalpha agonists. Optimum…”
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A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle by Treebak, Jonas T, Birk, Jesper B, Hansen, Bo F, Olsen, Grith S, Wojtaszewski, Jørgen F P

“…5'-AMP-activated protein kinase (AMPK) regulates several aspects of metabolism. Recently, A-769662 was shown to activate AMPK in skeletal muscle. However, no…”
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Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus: Overexpression of protein kinase C(epsilon) in skeletal muscle precedes the onset of by Ikeda, Yukio, Olsen, Grith S, Ziv, Ehud, Hansen, Lone L

“…The sand rat (Psammomys obesus) is an animal model of nutritionally induced diabetes. We report here that several protein kinase C (PKC) isoforms (alpha,…”
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Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus: overexpression of Protein Kinase C[[epsilon] in skeletal muscle precedes the onset of hyperinsulinemia and hyperglycemia by Ikeda, Yukio, Olsen, Grith S, Ziv, Ehud, Hansen, Lone L, Busch, Anna K, Hansen, Bo F, Shafrir, Eleazar, Mosthaf-Seedorf, Luitgard

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