Search Results - "OLLIARO, P"

Leishmaniasis chemotherapy—challenges and opportunities by Croft, S.L., Olliaro, P.

“…Although there have been significant advances in the treatment of visceral leishmaniasis (VL), there remain challenges to ensure that treatments effective in…”
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The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer) by Olliaro, Piero, Delgado-Romero, Petra, Keiser, Jennifer

“…Praziquantel has been the mainstay of schistosomiasis control since 1984 and widely distributed since 2006 through ‘preventive chemotherapy’ programmes to…”
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The Global Portfolio of New Antimalarial Medicines Under Development by Olliaro, P, Wells, TNC

“…With the elimination of malaria now considered a realistic goal, it would be useful for scientists and policy makers to have an inventory of the arsenal of…”
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Mode of action and mechanisms of resistance for antimalarial drugs by Olliaro, P

“…Understanding the mode of action of and mechanism of resistance to drugs is central to optimising their use, and discovering new therapeutics with novel…”
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Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial by Gomes, MF, Dr, Faiz, MA, Prof, Gyapong, JO, Prof, Warsame, M, MD, Agbenyega, T, Prof, Babiker, A, Prof, Baiden, F, MD, Yunus, EB, Prof, Binka, F, Prof, Clerk, C, MD, Folb, P, Prof, Hassan, R, MD, Hossain, MA, Prof, Kimbute, O, MA, Kitua, A, Prof, Krishna, S, Prof, Makasi, C, MD, Mensah, N, MSc, Mrango, Z, MD, Olliaro, P, Prof, Peto, R, Prof, Peto, TJ, MSc, Rahman, MR, Prof, Ribeiro, I, MD, Samad, R, MD, White, NJ, Prof

“…Summary Background Most malaria deaths occur in rural areas. Rapid progression from illness to death can be interrupted by prompt, effective medication…”
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A single LC–tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma by Hodel, E.M., Zanolari, B., Mercier, T., Biollaz, J., Keiser, J., Olliaro, P., Genton, B., Decosterd, L.A.

“…Among the various determinants of treatment response, the achievement of sufficient blood levels is essential for curing malaria. For helping us at improving…”
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Evaluation of the therapeutic efficacy of praziquantel against schistosomes in seven countries with ongoing large-scale deworming programs by Levecke, B., Vlaminck, J., Andriamaro, L., Ame, S., Belizario, V., Degarege, A., Engels, D., Erko, B., Garba, A.D., Kaatano, G.M., Mekonnen, Z., Montresor, A., Olliaro, P., Pieri, O.S., Sacko, M., Sam-Wobo, S.O., Tchuem Tchuenté, L.A., Webster, J.P., Vercruysse, J.

“…The World Health Organization (WHO) recommends periodic assessment of the therapeutic efficacy of praziquantel (PZQ) to detect reduced efficacy that may arise…”
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Anthropometrically derived dosing and drug costing calculations for treating visceral leishmaniasis in Bihar, India by Olliaro, P, Sundar, S

“…To estimate drug costs of treating visceral leishmaniasis (VL) based on data on the VL population structure from the high-burden, antimony-resistant area of…”
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Antimicrobial resistance diagnostic use accelerator – Behavioural determinants of point-of-care diagnostic uptake, and adherence to prescription by Horgan, P., Moore, C., Baiden, R., Basnyat, B., Dutta, S., Kapisi, J., Pathak, A., Phutke, G., Smithuis, F., Taneja, N., Tinto, H., Chadha, S., Tomar, A., Salami, O., Olliaro, P.

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Treatment of urinary schistosomiasis: methodological issues and research needs identified through a Cochrane systematic review by Danso-Appiah, A, Garner, P, Olliaro, P L, Utzinger, J

“…Guidelines recommend praziquantel (PZQ) for the treatment and control of schistosomiasis, with no real alternative. Metrifonate was still widely used against…”
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Severe falciparum malaria by World Health Organization

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An analytical method with a single extraction procedure and two separate high performance liquid chromatographic systems for the determination of artesunate, dihydroartemisinin and mefloquine in human plasma for application in clinical pharmacological studies of the drug combination by Lai, Choon-Sheen, Nair, N.K., Mansor, S.M., Olliaro, P.L., Navaratnam, V.

“…The combination of two sensitive, selective and reproducible reversed phase liquid chromatographic (RP-HPLC) methods was developed for the determination of…”
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Validation of high performance liquid chromatography–electrochemical detection methods with simultaneous extraction procedure for the determination of artesunate, dihydroartemisinin, amodiaquine and desethylamodiaquine in human plasma for application in clinical pharmacological studies of artesunate–amodiaquine drug combination by Lai, Choon-Sheen, Nair, N.K., Muniandy, A., Mansor, S.M., Olliaro, P.L., Navaratnam, V.

“…With the expanded use of the combination of artesunate (AS) and amodiaquine (AQ) for the treatment of falciparum malaria and the abundance of products on the…”
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Developing artemisinin based drug combinations for the treatment of drug resistant falciparum malaria: A review by Olliaro PL, Taylor WRJ

“…The emergence and spread of drug resistant malaria represents a considerable challenge to controlling malaria. To date, malaria control has relied heavily on a…”
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Efficacy of Artesunate Plus Amodiaquine versus That of Artemether-Lumefantrine for the Treatment of Uncomplicated Childhood Plasmodium falciparum Malaria in Zanzibar, Tanzania by Mårtensson, Andreas, Strömberg, Johan, Sisowath, Christin, Msellem, Mwinyi I., Gil, J. Pedro, Montgomery, Scott M., Olliaro, Piero, Ali, Abdullah S., Björkman, Anders

“…Background. This is the first clinical trial comparing the efficacy of artesunate plus amodiaquine (ASAQ) and artemether-lumefantrine (AL)—the major…”
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New Fixed-Dose Artesunate-Mefloquine Formulation against Multidrug-Resistant Plasmodium falciparum in Adults: a Comparative Phase IIb Safety and Pharmacokinetic Study with Standard-Dose Nonfixed Artesunate plus Mefloquine by Krudsood, S, Looareesuwan, S, Tangpukdee, N, Wilairatana, P, Phumratanaprapin, W, Leowattana, W, Chalermrut, K, Ramanathan, S, Navaratnam, V, Olliaro, P, Vaillant, M, Kiechel, J R, Taylor, W R J

“…ERRATUM ( vol. 54 , p. 4526 ) Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg…”
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Hypoxia modulates the effect of dihydroartemisinin on endothelial cells by D’Alessandro, S., Basilico, N., Corbett, Y., Scaccabarozzi, D., Omodeo-Salè, F., Saresella, M., Marventano, I., Vaillant, M., Olliaro, P., Taramelli, D.

“…Artemisinin derivatives, the current cornerstone of malaria treatment, possess also anti-angiogenic and anti-tumor activity. Hypoxia plays a crucial role both…”
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Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial by Adjuik, M, Agnamey, P, Babiker, A, Borrmann, S, Brasseur, P, Cisse, M, Cobelens, F, Diallo, S, Faucher, JF, Garner, P, Gikunda, S, Kremsner, PG, Krishna, S, Lell, B, Loolpapit, M, Matsiegui, P-B, Missinou, MA, Mwanza, J, Ntoumi, F, Olliaro, P, Osimbo, P, Rezbach, P, Some, E, Taylor, WRJ

“…Increasing drug resistance limits the choice of efficacious chemotherapy against Plasmodium falciparum malaria in Africa. Amodiaquine still retains efficacy…”
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Averting a malaria disaster by White, NJ, Nosten, F, Looareesuwan, S, Watkins, WM, Marsh, K, Snow, RW, Kokwaro, G, Ouma, J, Hien, TT, Molyneux, ME, Taylor, TE, Newbold, CI, Ruebush, TK, Danis, M, Greenwood, BM, Anderson, RM, Olliaro, P

“…As treatments loose their effectiveness, morbidity and mortality from malaria will inevitably continue to rise. The rationale for combining drugs with…”
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Population Pharmacokinetics of Intravenous Artesunate: A Pooled Analysis of Individual Data From Patients With Severe Malaria by Zaloumis, S G, Tarning, J, Krishna, S, Price, R N, White, N J, Davis, T M E, McCaw, J M, Olliaro, P, Maude, R J, Kremsner, P, Dondorp, A, Gomes, M, Barnes, K, Simpson, J A

“…There are ~660,000 deaths from severe malaria each year. Intravenous artesunate (i.v. ARS) is the first‐line treatment in adults and children. To optimize the…”
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