Search Results - "OLIVOTTO, Iacopo"

The spectrum of myocarditis: from pathology to the clinics by Leone, Ornella, Pieroni, Maurizio, Rapezzi, Claudio, Olivotto, Iacopo

“…Myocarditis is an inflammatory disease of the myocardium, which may occur in isolation or as part of systemic infectious/immune/autoimmune conditions,…”
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Cardiac Myosin Inhibitors as a Novel Treatment Option for Obstructive Hypertrophic Cardiomyopathy: Addressing the Core of the Matter by Masri, Ahmad, Olivotto, Iacopo

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MR Imaging in Hypertrophic Cardiomyopathy: From Magnet to Bedside by Bogaert, Jan, Olivotto, Iacopo

“…Hypertrophic cardiomyopathy ( HCM hypertrophic cardiomyopathy ), the most common genetically transmitted cardiac disorder, has been the focus of extensive…”
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Advantages and Perils of Clinical Whole-Exome and Whole-Genome Sequencing in Cardiomyopathy by Mazzarotto, Francesco, Olivotto, Iacopo, Walsh, Roddy

“…As the price of next-generation sequencing keeps decreasing, cost is becoming a less important discriminator for diagnostic laboratories in choosing the…”
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Occurrence of Clinically Diagnosed Hypertrophic Cardiomyopathy in the United States by Maron, Martin S., MD, Hellawell, Jennifer L., MD, Lucove, Jaime C., MSPH, Farzaneh-Far, Ramin, MD, Olivotto, Iacopo, MD

“…Abstract Hypertrophic cardiomyopathy (HC) is the most common genetic heart disease, and an important cause of sudden death and heart failure symptoms. The…”
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Pharmacological treatment of hypertrophic cardiomyopathy: current practice and novel perspectives by Ammirati, Enrico, Contri, Rachele, Coppini, Raffaele, Cecchi, Franco, Frigerio, Maria, Olivotto, Iacopo

“…Hypertrophic cardiomyopathy (HCM) is entering a phase of intense translational research that holds promise for major advances in disease‐specific…”
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Contemporary Natural History and Management of Nonobstructive Hypertrophic Cardiomyopathy by Maron, Martin S., MD, Rowin, Ethan J., MD, Olivotto, Iacopo, MD, Casey, Susan A., RN, Arretini, Anna, MD, Tomberli, Benedetta, MD, Garberich, Ross F., MS, Link, Mark S., MD, Chan, Raymond H.M., MD, Lesser, John R., MD, Maron, Barry J., MD

“…Abstract Background Left ventricular outflow tract gradients are absent in an important proportion of patients with hypertrophic cardiomyopathy (HCM). However,…”
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Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy by Toepfer, Christopher N., Garfinkel, Amanda C., Venturini, Gabriela, Wakimoto, Hiroko, Repetti, Giuliana, Alamo, Lorenzo, Sharma, Arun, Agarwal, Radhika, Ewoldt, Jourdan F., Cloonan, Paige, Letendre, Justin, Lun, Mingyue, Olivotto, Iacopo, Colan, Steve, Ashley, Euan, Jacoby, Daniel, Michels, Michelle, Redwood, Charles S., Watkins, Hugh C., Day, Sharlene M., Staples, James F., Padrón, Raúl, Chopra, Anant, Ho, Carolyn Y., Chen, Christopher S., Pereira, Alexandre C., Seidman, Jonathan G., Seidman, Christine E.

“…BACKGROUND:Hypertrophic cardiomyopathy (HCM) is caused by pathogenic variants in sarcomere protein genes that evoke hypercontractility, poor relaxation, and…”
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Systematic large-scale assessment of the genetic architecture of left ventricular noncompaction reveals diverse etiologies by Mazzarotto, Francesco, Hawley, Megan H., Beltrami, Matteo, Beekman, Leander, de Marvao, Antonio, McGurk, Kathryn A., Statton, Ben, Boschi, Beatrice, Girolami, Francesca, Roberts, Angharad M., Lodder, Elisabeth M., Allouba, Mona, Romeih, Soha, Aguib, Yasmine, Baksi, A. John, Pantazis, Antonis, Prasad, Sanjay K., Cerbai, Elisabetta, Yacoub, Magdi H., O’Regan, Declan P., Cook, Stuart A., Ware, James S., Funke, Birgit, Olivotto, Iacopo, Bezzina, Connie R., Barton, Paul J. R., Walsh, Roddy

“…Purpose To characterize the genetic architecture of left ventricular noncompaction (LVNC) and investigate the extent to which it may represent a distinct…”
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Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy by COPPINI, Raffaele, FERRANTINI, Cecilia, YACOUB, Magdi, OLIVOTTO, Iacopo, BELARDINELLI, Luiz, POGGESI, Corrado, CERBAI, Elisabetta, MUGELLI, Alessandro, LINA YAO, PEIDONG FAN, DEL LUNGO, Martina, STILLITANO, Francesca, SARTIANI, Laura, TOSI, Benedetta, SUFFREDINI, Silvia, TESI, Chiara

“…Hypertrophic cardiomyopathy (HCM), the most common mendelian heart disorder, remains an orphan of disease-specific pharmacological treatment because of the…”
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Mutation E169K in Junctophilin-2 Causes Atrial Fibrillation Due to Impaired RyR2 Stabilization by Beavers, David L., BS, Wang, Wei, PhD, Ather, Sameer, MD, PhD, Voigt, Niels, MD, Garbino, Alejandro, MD, PhD, Dixit, Sayali S., PhD, Landstrom, Andrew P., MD, PhD, Li, Na, PhD, Wang, Qiongling, PhD, Olivotto, Iacopo, MD, Dobrev, Dobromir, MD, Ackerman, Michael J., MD, PhD, Wehrens, Xander H.T., MD, PhD

“…Objectives This study sought to study the role of junctophilin-2 (JPH2) in atrial fibrillation (AF). Background JPH2 is believed to have an important role in…”
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Reevaluating the Genetic Contribution of Monogenic Dilated Cardiomyopathy by Mazzarotto, Francesco, Tayal, Upasana, Buchan, Rachel J., Midwinter, William, Wilk, Alicja, Whiffin, Nicola, Govind, Risha, Mazaika, Erica, de Marvao, Antonio, Dawes, Timothy J.W., Felkin, Leanne E., Ahmad, Mian, Theotokis, Pantazis I., Edwards, Elizabeth, Ing, Alexander Y., Thomson, Kate L., Chan, Laura L.H., Sim, David, Baksi, A. John, Pantazis, Antonis, Roberts, Angharad M., Watkins, Hugh, Funke, Birgit, O’Regan, Declan P., Olivotto, Iacopo, Barton, Paul J.R., Prasad, Sanjay K., Cook, Stuart A., Ware, James S., Walsh, Roddy

“…BACKGROUND:Dilated cardiomyopathy (DCM) is genetically heterogeneous, with >100 purported disease genes tested in clinical laboratories. However, many genes…”
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International External Validation Study of the 2014 European Society of Cardiology Guidelines on Sudden Cardiac Death Prevention in Hypertrophic Cardiomyopathy (EVIDENCE-HCM) by O’Mahony, Constantinos, Jichi, Fatima, Ommen, Steve R, Christiaans, Imke, Arbustini, Eloisa, Garcia-Pavia, Pablo, Cecchi, Franco, Olivotto, Iacopo, Kitaoka, Hiroaki, Gotsman, Israel, Carr-White, Gerald, Mogensen, Jens, Antoniades, Loizos, Mohiddin, Saidi A, Maurer, Mathew S, Tang, Hak Chiaw, Geske, Jeffrey B, Siontis, Konstantinos C, Mahmoud, Karim D, Vermeer, Alexa, Wilde, Arthur, Favalli, Valentina, Guttmann, Oliver P, Gallego-Delgado, Maria, Dominguez, Fernando, Tanini, Ilaria, Kubo, Toru, Keren, Andre, Bueser, Teofila, Waters, Sarah, Issa, Issa F, Malcolmson, James, Burns, Tom, Sekhri, Neha, Hoeger, Christopher W, Omar, Rumana Z, Elliott, Perry M

“…BACKGROUND:Identification of people with hypertrophic cardiomyopathy (HCM) who are at risk of sudden cardiac death (SCD) and require a prophylactic implantable…”
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Role of Exercise Testing in Hypertrophic Cardiomyopathy by Rowin, Ethan J., Maron, Barry J., Olivotto, Iacopo, Maron, Martin S.

“…Over the last 25 years, patients with hypertrophic cardiomyopathy (HCM) have been studied with a variety of methods employing physiological exercise that have…”
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The coronary circulation and blood flow in left ventricular hypertrophy by Camici, Paolo G, Olivotto, Iacopo, Rimoldi, Ornella E

“…Abstract Two distinct types of left ventricular hypertrophy (LVH) have been described: the so called “physiologic” hypertrophy, which is normally found in…”
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The Case for Myocardial Ischemia in Hypertrophic Cardiomyopathy by Maron, Martin S., MD, Olivotto, Iacopo, MD, Maron, Barry J., MD, Prasad, Sanjay K., MD, Cecchi, Franco, MD, Udelson, James E., MD, Camici, Paolo G., MD

“…Since its original description 50 years ago, myocardial ischemia has been a recognized but underappreciated aspect of the pathophysiology of hypertrophic…”
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Mitral Valve Abnormalities Identified by Cardiovascular Magnetic Resonance Represent a Primary Phenotypic Expression of Hypertrophic Cardiomyopathy by MARON, Martin S, OLIVOTTO, Iacopo, HARRIGAN, Caitlin, APPELBAUM, Evan, GIBSON, C. Michael, LESSER, John R, HAAS, Tammy S, UDELSON, James E, MANNING, Warren J, MARON, Barry J

“…Whether morphological abnormalities of the mitral valve represent part of the hypertrophic cardiomyopathy (HCM) disease process is unresolved. Therefore, we…”
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Pharmacological treatment options for hypertrophic cardiomyopathy: high time for evidence by SPOLADORE, Roberto, MARON, Martin S, D'AMATO, Rossella, CAMICI, Paolo G, OLIVOTTO, Lacopo

“…Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease, affecting over one million individuals in Europe. Hypertrophic cardiomyopathy…”
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Obesity and its Association to Phenotype and Clinical Course in Hypertrophic Cardiomyopathy by Olivotto, Iacopo, MD, Maron, Barry J., MD, Tomberli, Benedetta, MD, Appelbaum, Evan, MD, Salton, Carol, AB, Haas, Tammy S., RN, Gibson, C. Michael, MD, Nistri, Stefano, MD, Servettini, Eleonora, MD, Chan, Raymond H., MD, Udelson, James E., MD, Lesser, John R., MD, Cecchi, Franco, MD, Manning, Warren J., MD, Maron, Martin S., MD

“…Objectives This study sought to assess the impact of body mass index (BMI) on cardiac phenotypic and clinical course in a multicenter hypertrophic…”
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Contemporary Insights Into the Genetics of Hypertrophic Cardiomyopathy: Toward a New Era in Clinical Testing? by Mazzarotto, Francesco, Olivotto, Iacopo, Boschi, Beatrice, Girolami, Francesca, Poggesi, Corrado, Barton, Paul J R, Walsh, Roddy

“…Genetic testing for hypertrophic cardiomyopathy (HCM) is an established clinical technique, supported by 30 years of research into its genetic etiology…”
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