Search Results - "OLIVIER, Andree R"

A Selective Phosphatase of Regenerating Liver Phosphatase Inhibitor Suppresses Tumor Cell Anchorage-Independent Growth by a Novel Mechanism Involving p130Cas Cleavage by DAOUTI, Sherif, LI, Wen-Hui, HONGJIN BIAN, REIDHAAR-OLSON, John F, BLISS, Sarah A, OLIVIER, Andree R, SERGI, Joseph A, FRY, David, DANHO, Waleed, RITLAND, Steve, FOTOUHI, Nader, HEIMBROOK, David, HONG QIAN, HUIFENG NIU, HUANG, Kuo-Sen, HOLMGREN, Janna, LEVIN, Wayne, REIK, Linda, MCGADY, Debra Lucas, GILLESPIE, Paul, PERROTTA, Agostino

“…The phosphatase of regenerating liver (PRL) family, a unique class of oncogenic phosphatases, consists of three members: PRL-1, PRL-2, and PRL-3. Aberrant…”
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Design and synthesis of 2-N-substituted indazolone derivatives as non-carboxylic acid glycogen synthase activators by Qian, Yimin, Bolin, David, Conde-Knape, Karin, Gillespie, Paul, Hayden, Stuart, Huang, Kuo-Sen, Olivier, Andrée R., Sato, Tsutomu, Xiang, Qing, Yun, Weiya, Zhang, Xiaolei

“…Glycogen synthase (GS) catalyzes the transfer of glucose residues from UDP-glucose to a glycogen polymer chain, a critical step for glucose storage. Patients…”
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7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: Novel and highly selective protein tyrosine phosphatase 1B inhibitors by Cheung, Adrian Wai-Hing, Banner, Bruce, Bose, Jolly, Kim, Kyungjin, Li, Shiming, Marcopulos, Nicholas, Orzechowski, Lucja, Sergi, Joseph A., Thakkar, Kshitij C., Wang, Bing-Bing, Yun, Weiya, Zwingelstein, Catherine, Berthel, Steven, Olivier, Andrée R.

“…High throughput screening of the Roche compound collection led to the identification of diaminopyrroloquinazoline series as a novel class of PTP1B inhibitors…”
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Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity by Guertin, Kevin R., Setti, Lina, Qi, Lida, Dunsdon, Rachel M., Dymock, Brian W., Jones, Philip S., Overton, Hilary, Taylor, Mathew, Williams, Glyn, Sergi, Joseph A., Wang, Karen, Peng, Ying, Renzetti, Marcia, Boyce, Rogely, Falcioni, Fiorenza, Garippa, Ralph, Olivier, Andrée R.

“…A novel series of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents have been identified. These compounds show non-selective…”
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EGF induces biphasic S6 kinase activation: late phase is protein kinase C-dependent and contributes to mitogenicity by Susa, M, Olivier, A R, Fabbro, D, Thomas, G

“…Detailed kinetics reveal that EGF-induced S6 kinase activation is biphasic: an early phase appears at 10-15 min, followed by a late phase between 30 and 60…”
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Bombesin, platelet-derived growth factor, and diacylglycerol induce selective membrane association and down-regulation of protein kinase C isotypes in Swiss 3T3 cells by Olivier, A R, Parker, P J

“…Swiss 3T3 cells contain protein kinase C (PKC) isotypes alpha, delta, epsilon and zeta (Olivier, A. R., and Parker, P. J. (1992) J. Cell. Physiol. 152,…”
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Identification of multiple PKC isoforms in Swiss 3T3 cells: differential down-regulation by phorbol ester by Olivier, A R, Parker, P J

“…The expression of members of the Ca2+ and phospholipid-dependent protein kinase (PKC) family were studied in murine Swiss 3T3 cells. In addition to PKC-alpha,…”
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Expression and characterization of protein kinase C‐δ by OLIVIER, Andrée R., PARKER, Peter J.

“…A cDNA encoding protein kinase C‐δ (PKC‐δ) was isolated from a rat brain library. The coding region was subcloned into the expression vector pmt2 and…”
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Three forms of phosphatase type 1 in Swiss 3T3 fibroblasts. Free catalytic subunit appears to mediate s6 dephosphorylation by Olivier, A R, Thomas, G

“…The major 40 S ribosomal protein S6 phosphatase in Swiss mouse 3T3 fibroblasts is a type 1 enzyme (Olivier, A. R., Ballou, L. M., and Thomas, G. (1988) Proc…”
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Differential Regulation of S6 Phosphorylation by Insulin and Epidermal Growth Factor in Swiss Mouse 3T3 Cells: Insulin Activation of Type 1 Phosphatase by Olivier, Andrée R., Ballou, Lisa M., Thomas, George

“…Insulin and epidermal growth factor (EGF) induce distinct kinetics of S6 kinase activation and S6 phosphorylation in Swiss 3T3 cells. Both events are…”
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The co-mitogenic combination of transforming growth factor beta 1 and bombesin protects protein kinase C-delta from late-phase down-regulation, despite synergy in diacylglycerol accumulation by Olivier, A R, Hansra, G, Pettitt, T R, Wakelam, M J, Parker, P J

“…Bombesin induces the down-regulation of protein kinase C-delta (PKC-delta) and PKC-epsilon in Swiss 3T3 cells. Simultaneous addition of transforming growth…”
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12-Deoxyphorbol-13-O-phenylacetate-20-acetate is not protein kinase C-beta isozyme-selective in vivo by Kiley, S C, Olivier, A R, Gordge, P C, Ryves, W J, Evans, F J, Ways, D K, Parker, P J

“…The phorbol ester, 12-deoxyphorbol-13-O-phenylacetate-20-acetate (DOPPA) has been shown to activate specifically the protein kinase C (PKC)-beta 1 isozyme in…”
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Phorbol ester activation of the isotypes of protein kinase C from bovine and rat brain by Evans, F J, Parker, P J, Olivier, A R, Thomas, S, Ryves, W J, Evans, A T, Gordge, P, Sharma, P

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Analysis of 40S ribosomal protein S6 phosphorylation during the mitogenic response by Krieg, J, Olivier, A R, Thomas, G

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Protein kinase C by Parker, P J, Cook, P P, Olivier, A R, Pears, C, Ways, D K, Webster, C

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