Search Results - "OLIGINO, T"

Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium by YAO, Q, WANG, S, GAMBOTTO, A, GLORIOSO, J. C, EVANS, C. H, ROBBINS, P. D, GHIVIZZANI, S. C, OLIGINO, T. J

“…Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that primarily affects joints. In rheumatoid joints there is extensive synovial proliferation…”
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Effective Treatment of Established Murine Collagen-Induced Arthritis by Systemic Administration of Dendritic Cells Genetically Modified to Express IL-4 by Kim, Seon Hee, Kim, Sunyoung, Evans, Christopher H, Ghivizzani, Steven C, Oligino, Thomas, Robbins, Paul D

“…Dendritic cells (DC) are APCs that are able to stimulate or inhibit immune responses, depending on levels of expression of MHC class I and II costimulatory…”
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Development of herpes simplex virus replication-defective multigene vectors for combination gene therapy applications by KRISKY, D. M, MARCONI, P. C, OLIGINO, T. J, ROUSE, R. J. D, FINK, D. J, COHEN, J. B, WATKINS, S. C, GLORIOSO, I. C

“…Some gene therapy applications will require simultaneous expression of multiple gene products to achieve a therapeutic effect. In this study we describe the…”
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Vector systems for gene transfer to joints by Oligino, T J, Yao, Q, Ghivizzani, S C, Robbins, P

“…The prospects for the development of gene therapy treatments for certain orthopaedic diseases have been fueled by advances in the understanding of the…”
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Gene delivery to cartilage defects using coagulated bone marrow aspirate by PASCHER, A, PALMER, G. D, GHIVIZZANI, S. C, STEINERT, A, OLIGINO, T, GOUZE, E, GOUZE, J-N, BETZ, O, SPECTOR, M, ROBBINS, P. D, EVANS, C. H

“…The long-term goal of the present study is to develop a clinically applicable approach to enhance natural repair mechanisms within cartilage lesions by…”
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Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis by OLIGINO, T, GHIVIZZANI, S. C, WOLFE, D, LECHMAN, E. R, KRISKY, D, MI, Z, EVANS, C. H, ROBBINS, P. D, GLORIOSO, J

“…To evaluate the use of HSV-based vectors for arthritis gene therapy we have constructed a first-generation, ICP4 deficient, replication defective herpes…”
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Engineering Herpes Simplex Virus Vectors for CNS Applications by Wolfe, D., Goins, W.F., Yamada, M., Moriuchi, S., Krisky, D.M., Oligino, T.J., Marconi, P.C., Fink, D.J., Glorioso, J.C.

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Direct gene delivery strategies for the treatment of rheumatoid arthritis by Ghivizzani, Steven C, Oligino, Thomas J, Glorioso, Joseph C, Robbins, Paul D, Evans, Christopher H

“…Gene therapy offers a novel and innovative approach to the delivery of therapeutic proteins to the joints of patients with arthritis. Several viral vectors,…”
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Rapid method for construction of recombinant HSV gene transfer vectors by KRISKY, D. M, MARCONI, P. C, OLIGINO, T, ROUSE, R. J. D, FINK, D. J, GLORIOSO, J. C

“…Herpes simplex virus type 1 (HSV-1) is a neurotrophic human pathogen that naturally persists in neurons in a latent state and carries a large number of viral…”
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Gene therapy for autoimmune disorders by EVANS, C. H, GHIVIZZANI, S. C, OLIGINO, T. J, ROBBINS, P. D

“…Although many autoimmune disorders do not have a strong genetic basis, their treatment may nevertheless be improved by gene therapies. Most strategies seek to…”
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Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model by GOMEZ-NAVARRO, J, CONTRERAS, J. L, THOMAS, J. M, ARAFAT, W, JIANG, X. L, KRISKY, D, OLIGINO, T, MARCONI, P, HUBBARD, B, GLORIOSO, J. C, CURIEL, D. T

“…To develop a cellular vehicle able to reach systemically disseminated areas of angiogenesis, we sought to exploit the natural tropism of circulating…”
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Identification of target genes regulated by homeotic proteins in Drosophila melanogaster through genetic selection of Ultrabithorax protein-binding sites in yeast by Mastick, G.S. (University of Michigan, Ann Arbor, MI.), McKay, R, Oligino, T, Donovan, K, Lopez, A.J

“…A method based on the transcriptional activation of a selectable reporter in yeast cells was used to identify genes regulated by the Ultrabithorax…”
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Gene Delivery of IL-1Ra and Soluble TNF Receptor Confers a Distal Synergistic Therapeutic Effect in Antigen-Induced Arthritis by KIM, S, LECHMAN, E, NASH, J, OLIGINO, T, ROBBINS, P

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Identification of fat-cell enhancer regions in Drosophila melanogaster by Miller, J. M., Oligino, T., Pazdera, M., López, A. J., Hoshizaki, D. K.

“…The insect fat body is a dynamic tissue involved in maintaining homeostasis. It functions not only in energy storage and intermediary metabolism but also in…”
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Cartilage injury and repair by Ghivizzani, S C, Oligino, T J, Robbins, P D, Evans, C H

“…Articular cartilage is a complex structure that, once damaged, has little capacity for permanent repair. The problem lies in the inability of the body to…”
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Drug inducible transgene expression in brain using a herpes simplex virus vector by OLIGINO, T, POLIANI, P. L, WANG, Y, TSAI, S. Y, O'MALLEY, B. W, FINK, D. J, GLORIOSO, J. C

“…The ability to regulate transgene expression is likely to be important in the use of gene transfer to treat diseases of the central nervous system (CNS). In…”
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Gene therapy approaches for treating rheumatoid arthritis by Ghivizzani, S C, Oligino, T J, Glorioso, J C, Robbins, P D, Evans, C H

“…Current gene therapy approaches for treating rheumatoid arthritis have made use of gene transfer technology as an improved delivery system for emerging…”
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Gene Transfer of p53 to Arthritic Joints Stimulates Synovial Apoptosis and Inhibits Inflammation by Yao, Qingping, Wang, Sujing, Glorioso, Joseph C., Evans, Christopher H., Robbins, Paul D., Ghivizzani, Steven C., Oligino, Thomas J.

“…Rheumatoid arthritis (RA) is an autoimmune disease that primarily affects joints. During the pathogenesis of rheumatoid arthritis, the synovial lining becomes…”
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Adenoviral mediated delivery of FAS ligand to arthritic joints causes extensive apoptosis in the synovial lining by Yao, Qingping, Glorioso, Joseph C., Evans, Christopher H., Robbins, Paul D., Kovesdi, Imre, Oligino, Thomas J., Ghivizzani, Steven C.

“…Background Rheumatoid arthritis (RA) is an autoimmune disease where the synovial lining layer of the joint becomes thickened, hypercellular, and highly…”
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In vivo transgene activation from an HSV-based gene therapy vector by GAL4:vp16 by Oligino, T, Poliani, P L, Marconi, P, Bender, M A, Schmidt, M C, Fink, D J, Glorioso, J C

“…Herpes simplex virus type 1 (HSV-1) has many attributes which make it attractive as a base for the development of vectors for the delivery of transgenes to the…”
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