Search Results - "OLEJNICZAK, Scott"

CD28 co-stimulation: novel insights and applications in cancer immunotherapy by Lotze, Michael T, Olejniczak, Scott H, Skokos, Dimitris

“…Substantial progress in understanding T cell signalling, particularly with respect to T cell co-receptors such as the co-stimulatory receptor CD28, has been…”
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Co-Stimulatory Receptor Signaling in CAR-T Cells by Honikel, Mackenzie M, Olejniczak, Scott H

“…T cell engineering strategies have emerged as successful immunotherapeutic approaches for the treatment of human cancer. Chimeric Antigen Receptor T (CAR-T)…”
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β-Adrenergic signaling blocks murine CD8+ T-cell metabolic reprogramming during activation: a mechanism for immunosuppression by adrenergic stress by Qiao, Guanxi, Bucsek, Mark J., Winder, Nicolette M., Chen, Minhui, Giridharan, Thejaswini, Olejniczak, Scott H., Hylander, Bonnie L., Repasky, Elizabeth A.

“…Primary and secondary lymphoid organs are heavily innervated by the autonomic nervous system. Norepinephrine, the primary neurotransmitter secreted by…”
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Ars2 Promotes Proper Replication-Dependent Histone mRNA 3′ End Formation by Gruber, Joshua J., Olejniczak, Scott H., Yong, Jeongsik, La Rocca, Gaspare, Dreyfuss, Gideon, Thompson, Craig B.

“…Ars2 is a component of the nuclear cap-binding complex that contributes to microRNA biogenesis and is required for cellular proliferation. Here, we expand on…”
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Targeting of chimeric antigen receptor T cell metabolism to improve therapeutic outcomes by Nanjireddy, Priyanka Maridhi, Olejniczak, Scott H, Buxbaum, Nataliya Prokopenko

“…Genetically engineered chimeric antigen receptor (CAR) T cells can cure patients with cancers that are refractory to standard therapeutic approaches. To date,…”
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Pro-survival signaling regulates lipophagy essential for multiple myeloma resistance to stress-induced death by Peng, Peng, Chavel, Colin, Liu, Wensheng, Carlson, Louise M., Cao, Sha, Utley, Adam, Olejniczak, Scott H., Lee, Kelvin P.

“…Pro-survival metabolic adaptations to stress in tumorigenesis remain less well defined. We find that multiple myeloma (MM) is unexpectedly dependent on…”
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In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA by La Rocca, Gaspare, Olejniczak, Scott H., González, Alvaro J., Briskin, Daniel, Vidigal, Joana A., Spraggon, Lee, DeMatteo, Raymond G., Radler, Megan R., Lindsten, Tullia, Ventura, Andrea, Tuschl, Thomas, Leslie, Christina S., Thompson, Craig B.

“…MicroRNAs repress mRNA translation by guiding Argonaute proteins to partially complementary binding sites, primarily within the 3′ untranslated region (UTR) of…”
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DNMT1 Is Regulated by ATP-Citrate Lyase and Maintains Methylation Patterns during Adipocyte Differentiation by Londoño Gentile, Tatiana, Lu, Chao, Lodato, Peter M., Tse, Sarah, Olejniczak, Scott H., Witze, Eric S., Thompson, Craig B., Wellen, Kathryn E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Long-lived microRNA–Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses by Olejniczak, Scott H., La Rocca, Gaspare, Gruber, Joshua J., Thompson, Craig B.

“…Cellular proliferation depends on the integration of mitogenic stimuli with environmental conditions. Increasing evidence suggests that microRNAs play a…”
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Regulation of CD20 in Rituximab-Resistant Cell Lines and B-cell Non-Hodgkin Lymphoma by TSAI, Ping-Chiao, HERNANDEZ-ILIZALITURRI, Francisco J, BANGIA, Naveen, OLEJNICZAK, Scott H, CZUCZMAN, Myron S

“…The aim of this research was to further investigate the contribution of CD20 antigen expression to rituximab activity and define the mechanisms responsible for…”
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CD28 Regulates Metabolic Fitness for Long-Lived Plasma Cell Survival by Utley, Adam, Chavel, Colin, Lightman, Shivana, Holling, G. Aaron, Cooper, James, Peng, Peng, Liu, Wensheng, Barwick, Benjamin G., Gavile, Catherine M., Maguire, Orla, Murray-Dupuis, Megan, Rozanski, Cheryl, Jordan, Martha S., Kambayashi, Taku, Olejniczak, Scott H., Boise, Lawrence H., Lee, Kelvin P.

“…Durable humoral immunity against epidemic infectious disease requires the survival of long-lived plasma cells (LLPCs). LLPC longevity is dependent on metabolic…”
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Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses by Lightman, Shivana M., Peresie, Jennifer L., Carlson, Louise M., Holling, G. Aaron, Honikel, Mackenzie M., Chavel, Colin A., Nemeth, Michael J., Olejniczak, Scott H., Lee, Kelvin P.

“…Humoral immunity is essential for protection against pathogens, emphasized by the prevention of 2–3 million deaths worldwide annually by childhood…”
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Cardiotoxic profiles of CAR-T therapy and bispecific T-cell engagers in hematological cancers by Karthikeyan, Badri, Sunder, Sunitha Shyam, Puzanov, Igor, Olejniczak, Scott H., Pokharel, Saraswati, Sharma, Umesh C.

“…Background Chimeric antigen receptor (CAR) T-cell therapy and bispecific T-cell engagers, which redirect T-cells to tumor antigens, have immensely benefitted…”
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Acquirement of Rituximab Resistance in Lymphoma Cell Lines Is Associated with Both Global CD20 Gene and Protein Down-Regulation Regulated at the Pretranscriptional and Posttranscriptional Levels by CZUCZMAN, Myron S, OLEJNICZAK, Scott, GOWDA, Aruna, KOTOWSKI, Adam, BINDER, Arvinder, KAUR, Harman, KNIGHT, Joy, STAROSTIK, Petr, DEANS, Julie, HERNANDEZ-LLIZALITURRI, Francisco J

“…Acquirement of resistance to rituximab has been observed in lymphoma patients. To define mechanisms associated with rituximab resistance, we developed various…”
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How murine models of human disease and immunity are influenced by housing temperature and mild thermal stress by James, Caitlin M., Olejniczak, Scott H., Repasky, Elizabeth A.

“…At the direction of The Guide and Use of Laboratory Animals, rodents in laboratory facilities are housed at ambient temperatures between 20°C and 26°C, which…”
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The RNA binding protein Ars2 supports hematopoiesis at multiple levels by Elahi, Seerat, Egan, Shawn M., Holling, G. Aaron, Kandefer, Rachel L., Nemeth, Michael J., Olejniczak, Scott H.

“…•In vivo maintenance of the long-term hematopoietic stem cell (LT-HSC) pool relies on the RNA-binding protein arsenic resistance protein 2 (Ars2).•Ars2…”
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Improved hematopoietic differentiation of mouse embryonic stem cells through manipulation of the RNA binding protein ARS2 by Elahi, Seerat, Holling, G. Aaron, Stablewski, Aimee B., Olejniczak, Scott H.

“…•An inducible ARS2 knockout mouse ESC line was established.•Efficiency of hematopoietic differentiation of ESC was improved by ARS2 knockout.•ARS2 knockout ESC…”
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Coordinated Regulation of Cap-Dependent Translation and MicroRNA Function by Convergent Signaling Pathways by Olejniczak, Scott H., La Rocca, Gaspare, Radler, Megan R., Egan, Shawn M., Xiang, Qing, Garippa, Ralph, Thompson, Craig B.

“…Cell growth and proliferation require the coordinated activation of many cellular processes, including cap-dependent mRNA translation. MicroRNAs oppose…”
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Acquired Resistance to Rituximab Is Associated with Chemotherapy Resistance Resulting from Decreased Bax and Bak Expression by OLEJNICZAK, Scott H, HERNANDEZ-LLIZALITURRI, Francisco J, CLEMENTS, James L, CZUCZMAN, Myron S

“…Purpose: Targeting malignant B cells using rituximab (anti-CD20) has improved the efficacy of chemotherapy regimens used to treat patients with non-Hodgkin's…”
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CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity by Holling, G. Aaron, Chavel, Colin A., Sharda, Anand P., Lieberman, Mackenzie M., James, Caitlin M., Lightman, Shivana M., Tong, Jason H., Qiao, Guanxi, Emmons, Tiffany R., Giridharan, Thejaswini, Hou, Shengqi, Intlekofer, Andrew M., Higashi, Richard M., Fan, Teresa W. M., Lane, Andrew N., Eng, Kevin H., Segal, Brahm H., Repasky, Elizabeth A., Lee, Kelvin P., Olejniczak, Scott H.

“…Metabolic flexibility has emerged as a critical determinant of CD8+ T-cell antitumor activity, yet the mechanisms driving the metabolic flexibility of T cells…”
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