Search Results - "OLEFSKY, J"

Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer by Chung, H, Lee, Y S, Mayoral, R, Oh, D Y, Siu, J T, Webster, N J, Sears, D D, Olefsky, J M, Ellies, L G

“…Obesity and inflammation are both risk factors for a variety of cancers, including breast cancer in postmenopausal women. Intake of omega-3 polyunsaturated…”
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Thiazolidinediones in the treatment of insulin resistance and type II diabetes by Saltiel, A. R., Olefsky, J. M.

“…Thiazolidinediones in the treatment of insulin resistance and type II diabetes. A R Saltiel and J M Olefsky Department of Signal Transduction, Parke-Davis…”
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Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists by Olefsky, J M

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Variance-modeled posterior inference of microarray data: detecting gene-expression changes in 3T3-L1 adipocytes by Hsiao, A., Worrall, D. S., Olefsky, J. M., Subramaniam, S.

“…Motivation: Microarrays are becoming an increasingly common tool for observing changes in gene expression over a large cross section of the genome. This…”
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PPARγ and the Treatment of Insulin Resistance by Olefsky, Jerrold M, Saltiel, Alan R

“…Numerous studies across several population groups have indicated that insulin resistance plays a central role in the development of type 2 diabetes mellitus…”
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Nuclear Receptor Minireview Series by Olefsky, Jerrold M.

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Thiazolidinediones in the treatment of insulin resistance and type II diabetes by SALTIEL, A. R, OLEFSKY, J. M

“…Insulin resistance, characterized by reduced responsiveness to normal circulating concentrations of insulin, is a common feature of almost all patients with…”
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VAMPIRE microarray suite: a web-based platform for the interpretation of gene expression data by Hsiao, Albert, Ideker, Trey, Olefsky, Jerrold M., Subramaniam, Shankar

“…Microarrays are invaluable high-throughput tools used to snapshot the gene expression profiles of cells and tissues. Among the most basic and fundamental…”
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Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle by He, W, Barak, Y, Hevener, A, Olson, P, Liao, D, Le, J, Nelson, M, Ong, E, Olefsky, J.M, Evans, R.M

“…Syndrome X, typified by obesity, insulin resistance (IR), dyslipidemia, and other metabolic abnormalities, is responsive to antidiabetic thiazolidinediones…”
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Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects by Kruszynska, Y T, Yu, J G, Olefsky, J M, Sobel, B E

“…Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects. Y…”
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Metabolic effects of Troglitazone monotherapy in type 2 diabetes mellitus : A randomized, double-blind, placebo-controlled trial by MAGGS, D. G, BUCHANAN, T. A, POLONSKY, K. S, SILVER, D, VALIQUETT, T. R, SHULMAN, G. I, BURANT, C. F, CLINE, G, GUMBINER, B, HSUEH, W. A, INZUCCHI, S, KELLEY, D, NOLAN, J, OLEFSKY, J. M

“…Troglitazone is a new insulin-sensitizing agent used to treat type 2 diabetes mellitus. The mechanism by which troglitazone exerts its effect on systemic…”
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A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1 by Haruta, T, Uno, T, Kawahara, J, Takano, A, Egawa, K, Sharma, P M, Olefsky, J M, Kobayashi, M

“…Insulin receptor substrate-1 (IRS-1) is a major substrate of the insulin receptor and acts as a docking protein for Src homology 2 domain containing signaling…”
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Effects of Peroxisome Proliferator-Activated Receptor δ on Placentation, Adiposity, and Colorectal Cancer by Barak, Yaacov, Liao, Debbie, He, Weimin, Ong, Estelita S., Nelson, Michael C., Olefsky, Jerrold M., Boland, Richard, Evans, Ronald M.

“…Targeting of the nuclear prostaglandin receptor peroxisome proliferator-activated receptor δ (PPARδ) by homologous recombination results in placental defects…”
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A comparison of troglitazone and metformin on insulin requirements in euglycemic intensively insulin-treated type 2 diabetic patients by YU, J. G, KRUSZYNSKA, Y. T, MULFORD, M. I, OLEFSKY, J. M

“…A comparison of troglitazone and metformin on insulin requirements in euglycemic intensively insulin-treated type 2 diabetic patients. J G Yu , Y T Kruszynska…”
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Protein tyrosine phosphatase 1B interacts with the activated insulin receptor by Seely, B. L., Staubs, P. A., Reichart, D. R., Berhanu, P., Milarski, K. L., Saltiel, A. R., Kusari, J., Olefsky, J. M.

“…Protein tyrosine phosphatase 1B interacts with the activated insulin receptor. B L Seely , P A Staubs , D R Reichart , P Berhanu , K L Milarski , A R Saltiel ,…”
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Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency by Miles, P D, Barak, Y, He, W, Evans, R M, Olefsky, J M

“…The thiazolidinedione class of insulin-sensitizing, antidiabetic drugs interacts with peroxisome proliferator-activated receptor gamma (PPAR-gamma). To gain…”
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Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects by SUTER, S. L, NOLAN, J. J, WALLACE, P, GUMBINER, B, OLEFSKY, J. M

“…Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects. S L Suter , J J Nolan , P Wallace , B Gumbiner and J M Olefsky Department of…”
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Diabetes Gene therapy for rats and mice by Olefsky, Jerrold M

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TNF-α-induced insulin resistance in vivo and its prevention by troglitazone by MILES, P. D. G, ROMEO, O. M, HIGO, K, COHEN, A, RAFAAT, K, OLEFSKY, J. M

“…Tumor necrosis factor (TNF)-alpha may play a role in the insulin resistance of obesity and NIDDM. Troglitazone is a new orally active hypoglycemic agent that…”
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TNF-alpha-induced insulin resistance in vivo and its prevention by troglitazone by Miles, P. D., Romeo, O. M., Higo, K., Cohen, A., Rafaat, K., Olefsky, J. M.

“…TNF-alpha-induced insulin resistance in vivo and its prevention by troglitazone. P D Miles , O M Romeo , K Higo , A Cohen , K Rafaat and J M Olefsky Department…”
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