Search Results - "OLD, L. J"

Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase by Kelly, M P, Jungbluth, A A, Wu, B-W, Bomalaski, J, Old, L J, Ritter, G

“…Background: Some cancers have been shown to lack expression of argininosuccinate synthetase (ASS), an enzyme required for the synthesis of arginine and a…”
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T Cell Assays and MIATA: The Essential Minimum for Maximum Impact by Britten, C.M., Janetzki, S., Butterfield, L.H., Ferrari, G., Gouttefangeas, C., Huber, C., Kalos, M., Levitsky, H.I., Maecker, H.T., Melief, C.J.M., O’Donnell-Tormey, J., Odunsi, K., Old, L.J., Ottenhoff, T.H.M., Ottensmeier, C., Pawelec, G., Roederer, M., Roep, B.O., Romero, P., van der Burg, S.H., Walter, S., Hoos, A., Davis, M.M.

“…[...]the current version of MIATA is a testimonial to the freedom and transparency of research and proves the ability of the research community to form…”
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Minimal information about T cell assays: the process of reaching the community of T cell immunologists in cancer and beyond by Britten, C. M., Janetzki, S., van der Burg, S. H., Huber, C., Kalos, M., Levitsky, H. I., Maecker, H. T., Melief, C. J. M., O’Donnell-Tormey, J., Odunsi, K., Old, L. J., Pawelec, G., Roep, B. O., Romero, P., Hoos, A., Davis, M. M.

“…Many assays to evaluate the nature, breadth, and quality of antigen-specific T cell responses are currently applied in human medicine. In most cases,…”
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Multimarker RT-PCR assay for the detection of minimal residual disease in sentinel lymph nodes of breast cancer patients by NISSAN, A, JAGER, D, MITRANI-ROSENBAUM, S, ROYSTACHER, M, PRUS, D, PERETZ, T, EISENBERG, I, FREUND, H. R, SCANLAN, M, RITTER, G, OLD, L. J

“…The presence of metastases in lymph nodes is the most powerful prognostic factor in breast cancer patients. Routine histological examination of lymph nodes has…”
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New paths in human cancer serology by Old, L J, Chen, Y T

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Immunoreactivity for A103, an antibody to Melan-A (Mart-1), in adrenocortical and other steroid tumors by BUSAM, K. J, IVERSEN, K, COPLAN, K. A, OLD, L. J, STOCKERT, E, CHEN, Y.-T, MCGREGOR, D, JUNGBLUTH, A

“…The Melan-A (MART-1) gene encodes an antigen recognized by cytotoxic T cells. It has been said to be restricted in its expression to melanocytes. However, here…”
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Monoclonal antibody MA454 reveals a heterogeneous expression pattern of MAGE-1 antigen in formalin-fixed paraffin embedded lung tumours by JUNGBLUTH, A. A, STOCKERT, E, CHEN, Y.-T, KOLB, D, IVERSEN, K, COPLAN, K, WILLIAMSON, B, ALTORKI, N, BUSAM, K. J, OLD, L. J

“…Cancer/testis (CT) antigens such as those encoded by the MAGE-gene family are expressed in a wide variety of malignant neoplasms. In normal tissues, expression…”
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Serological analysis of human anti-human antibody responses in colon cancer patients treated with repeated doses of humanized monoclonal antibody A33 by RITTER, Gerd, COHEN, Leonard S, WILLIAMS, Clarence JR, RICHARDS, Elizabeth C, OLD, Lloyd J, WELT, Sydney

“…Mouse monoclonal antibody A33 (mAb A33) recognizes a M(r) 43,000 cell surface glycoprotein (designated A33) expressed in human colonic epithelium and colon…”
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Humoral immune responses of cancer patients against “Cancer‐Testis” antigen NY‐ESO‐1: Correlation with clinical events by Jäger, Elke, Stockert, Elisabeth, Zidianakis, Zacharias, Chen, Yao‐Tseng, Karbach, Julia, Jäger, Dirk, Arand, Michael, Ritter, Gerd, Old, Lloyd J., Knuth, Alexander

“…Humoral immune responses against the “Cancer‐Testis” (CT) antigen NY‐ESO‐1 are frequently observed in patients with NY‐ESO‐1 expressing tumors. This is in…”
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Phase I/II radioimmunotherapy trial with iodine-131-labeled monoclonal antibody G250 in metastatic renal cell carcinoma by Divgi, C R, Bander, N H, Scott, A M, O'Donoghue, J A, Sgouros, G, Welt, S, Finn, R D, Morrissey, F, Capitelli, P, Williams, J M, Deland, D, Nakhre, A, Oosterwijk, E, Gulec, S, Graham, M C, Larson, S M, Old, L J

“…This Phase I/II radioimmunotherapy study was carried out to determine the maximum tolerated dose (MTD) and therapeutic potential of 131I-G250. Thirty-three…”
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A33scFv-cytosine deaminase: a recombinant protein construct for antibody-directed enzyme-prodrug therapy by DECKERT, P. M, RENNER, C, COHEN, L. S, JUNGBLUTH, A, RITTER, G, BERTINO, J. R, OLD, L. J, WELT, S

“…A recombinant fusion protein of colon carcinoma binding A33 single chain antibody with cytosine deaminase displayed specific antigen binding and enzyme…”
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Phase I/II study of iodine 125-labeled monoclonal antibody A33 in patients with advanced colon cancer by Welt, S, Scott, A M, Divgi, C R, Kemeny, N E, Finn, R D, Daghighian, F, Germain, J S, Richards, E C, Larson, S M, Old, L J

“…A phase I/II study was designed to determine the maximum-tolerated dose (MTD) of iodine 125-labeled monoclonal antibody A33 (125I-mAb A33), its limiting organ…”
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Cell Surface Glycoprotein of Reactive Stromal Fibroblasts as a Potential Antibody Target in Human Epithelial Cancers by Garin-Chesa, Pilar, Old, Lloyd J., Rettig, Wolfgang J.

“…The F19 antigen is a cell surface glycoprotein (Mr, 95,000) of human sarcomas and proliferating, cultured fibroblasts that is absent from resting fibroblasts…”
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Characterization of human colon cancer antigens recognized by autologous antibodies by Scanlan, Matthew J., Chen, Yao‐Tseng, Williamson, Barbara, Gure, Ali O., Stockert, Elisabeth, Gordan, John D., Türeci, Özlem, Sahin, Ugur, Pfreundschuh, Michael, Old, Lloyd J.

“…The screening of cDNA expression libraries derived from human tumors with autologous antibody (SEREX) has proven to be a powerful method for defining the…”
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Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micrometastases by Cote, R J, Rosen, P P, Lesser, M L, Old, L J, Osborne, M P

“…We used monoclonal antibodies to identify occult micrometastases in the bone marrow of 49 patients with operable (stage I and II) breast carcinoma. Follow-up…”
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Characterization of Tumor Necrosis Factor-Deficient Mice by Marino, Michael W., Dunn, Ashley, Grail, Dianne, Inglese, Melissa, Noguchi, Yuji, Richards, Elizabeth, Jungbluth, Achim, Wada, Hisashi, Moore, Malcolm, Williamson, Barbara, Basu, Sunanda, Old, Lloyd J.

“…Although tumor necrosis factor (TNF) initially came to prominence because of its anti-tumor activity, most attention is now focused on its proinflammatory…”
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Trophoblast and ovarian cancer antigen LK26. Sensitivity and specificity in immunopathology and molecular identification as a folate- binding protein by Garin-Chesa, P, Campbell, I, Saigo, PE, Lewis, JL, Jr, Old, LJ, Rettig, WJ

“…The LK26 antigen is a cell surface glycoprotein (M(r)35,000 to 40,000) of normal placenta and gestational choriocarcinomas that shows highly restricted…”
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CTdatabase: a knowledge-base of high-throughput and curated data on cancer-testis antigens by Almeida, Luiz Gonzaga, Sakabe, Noboru J, deOliveira, Alice R, Silva, Maria Cristina C, Mundstein, Alex S, Cohen, Tzeela, Chen, Yao-Tseng, Chua, Ramon, Gurung, Sita, Gnjatic, Sacha, Jungbluth, Achim A, Caballero, Otávia L, Bairoch, Amos, Kiesler, Eva, White, Sarah L, Simpson, Andrew J.G, Old, Lloyd J, Camargo, Anamaria A, Vasconcelos, Ana Tereza R

“…The potency of the immune response has still to be harnessed effectively to combat human cancers. However, the discovery of T-cell targets in melanomas and…”
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Antigens recognized by autologous antibody in patients with renal‐cell carcinoma by Scanlan, Matthew J., Gordan, John D., Williamson, Barbara, Stockert, Elisabeth, Bander, Neil H., Jongeneel, Victor, Gure, Ali O., Jäger, Dirk, Jäger, Elke, Knuth, Alexander, Chen, Yao‐Tseng, Old, Lloyd J.

“…The screening of cDNA expression libraries derived from human tumors with autologous antibody (SEREX) is a powerful method for defining the structure of tumor…”
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A103: An anti-melan-A monoclonal antibody for the detection of malignant melanoma in paraffin-embedded tissues by JUNGBLUTH, A. A, BUSAM, K. J, GERALD, W. L, STOCKERT, E, COPLAN, K. A, IVERSEN, K, MACGREGOR, D. P, OLD, L. J, CHEN, Y.-T

“…Melan-A is a previously defined, melanocyte differentiation antigen, and an anti-Melan-A murine monoclonal antibody, A103, was recently developed by our group…”
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