Search Results - "OKUYAMA, YUKO"

Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction by Ogura, Hideki, Murakami, Masaaki, Okuyama, Yuko, Tsuruoka, Mineko, Kitabayashi, Chika, Kanamoto, Minoru, Nishihara, Mika, Iwakura, Yoichiro, Hirano, Toshio

“…Dysregulated cytokine expression and signaling are major contributors to a number of autoimmune diseases. Interleukin-17A (IL-17A) and IL-6 are important in…”
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OX40 Ligand-Mannose-Binding Lectin Fusion Protein Induces Potent OX40 Cosignaling in CD4+ T Cells by Sato, Ayaka, Azuma, Mitsuki, Nagai, Hodaka, Imai, Wakana, Kawaguchi, Kosuke, Morita, Masashi, Okuyama, Yuko, Ishii, Naoto, So, Takanori

“…OX40, a member of the tumor necrosis factor (TNF) receptor superfamily, is induced on activated T cells. Membrane-bound OX40 ligand (OX40L) expressed by…”
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TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development by Nagashima, Hiroyuki, Okuyama, Yuko, Hayashi, Takaya, Ishii, Naoto, So, Takanori

“…IL-17-producing CD4(+) T cells (Th17 cells) regulate host defense and immune pathogenesis, and IL-6 plays an important role for the differentiation of Th17…”
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Rbm10 regulates inflammation development via alternative splicing of Dnmt3b by Atsumi, Toru, Suzuki, Hironao, Jiang, Jing-Jing, Okuyama, Yuko, Nakagawa, Ikuma, Ota, Mitsutoshi, Tanaka, Yuki, Ohki, Takuto, Katsunuma, Kokichi, Nakajima, Koichi, Hasegawa, Yoshinori, Ohara, Osamu, Ogura, Hideki, Arima, Yasunobu, Kamimura, Daisuke, Murakami, Masaaki

“…RNA-binding motif 10 (Rbm10) is an RNA-binding protein that regulates alternative splicing, but its role in inflammation is not well defined. Here, we show…”
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TRAF2 and TRAF5 associated with the signal transducing receptor gp130 limit IL-6-driven transphosphorylation of JAK1 through the inhibition of proximal JAK–JAK interaction by Kimura, Masanobu, Nagashima, Hiroyuki, Okuyama, Yuko, Ishii, Naoto, So, Takanori

“…TRAF-family members prevent IL-6R-mediated JAK-JAK interaction Abstract Tumor necrosis factor receptor-associated factor 2 (TRAF2) and TRAF5 constitutively…”
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The role of fatty acid binding protein 7 in spinal cord astrocytes in a mouse model of experimental autoimmune encephalomyelitis by Kamizato, Kenyu, Sato, Sho, Shil, Subrata Kumar, Umaru, Banlanjo A., Kagawa, Yoshiteru, Yamamoto, Yui, Ogata, Masaki, Yasumoto, Yuki, Okuyama, Yuko, Ishii, Naoto, Owada, Yuji, Miyazaki, Hirofumi

“…Fatty acid binding protein 7 (FABP7) is expressed in astrocytes of the developing and mature central nervous system, and modulates astrocyte function by…”
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GITR controls intestinal inflammation by suppressing IL‐15‐dependent NK cell activity by Sakurai, Tsuyoshi, Okuyama, Yuko, Kobayashi, Shuhei, Phung, Hai The, Asao, Atsuko, Kawabe, Takeshi, Ndhlovu, Lishomwa C., Riccardi, Carlo, Kudo, Hironori, Wada, Motoshi, Nio, Masaki, So, Takanori, Ishii, Naoto

“…Glucocorticoid‐induced TNFR family related gene (GITR) is a member of the TNFR superfamily that is expressed on cells of the immune system. Although the…”
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IQ motif-containing GTPase-activating protein 1 is essential for the optimal maintenance of lung ILC2s by Tayama, Shunichi, Okuyama, Yuko, Phung, Hai The, Asao, Atsuko, Kobayashi, Shuhei, Musha, Tomomi, Machiyama, Tomoaki, Sakurai, Tsuyoshi, Zhang, Chengming, Ushio-Fukai, Masuko, Kawabe, Takeshi, So, Takanori, Ishii, Naoto

“…Abstract Group 2 innate lymphoid cells (ILC2s) play critical roles in type 2 immunity and are crucial for pathogenesis of various types of inflammatory…”
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Antiviral Activities of Hibiscus sabdariffa L. Tea Extract Against Human Influenza A Virus Rely Largely on Acidic pH but Partially on a Low-pH-Independent Mechanism by Takeda, Yohei, Okuyama, Yuko, Nakano, Hiroto, Yaoita, Yasunori, Machida, Koich, Ogawa, Haruko, Imai, Kunitoshi

“…Influenza A virus (IAV) infection is perennially one of the leading causes of death worldwide. Effective therapy and vaccination are needed to control viral…”
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ADL Outcome of Stroke by Stroke Type and Time from Onset to Admission to a Comprehensive Inpatient Rehabilitation Ward by Matsubara, Masanori, Sonoda, Shigeru, Watanabe, Makoto, Okuyama, Yuko, Okazaki, Hideto, Okamoto, Sayaka, Mizuno, Shiho

“…To examine the effect of onset to admission interval (OAI) and stroke type on activities of daily living (ADL) outcome. Stroke patients (n=3112) admitted to…”
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TNF receptor associated factor 5 controls oncostatin M-mediated lung inflammation by Machiyama, Tomoaki, So, Takanori, Okuyama, Yuko, Kobayashi, Shuhei, Phung, Hai The, Asao, Atsuko, Harigae, Hideo, Ishii, Naoto

“…Oncostatin M (OSM) is involved in pathogenesis of several human inflammatory diseases including lung inflammation and fibrosis. Although accumulating evidence…”
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Catalytic Efficiency of Primary α-Amino Amides as Multifunctional Organocatalysts in Recent Asymmetric Organic Transformations by Ummareddy Venkata Subba Reddy, Bheemreddy Anusha, Zubeda Begum, Chigusa Seki, Yuko Okuyama, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano

“…Chiral primary α-amino amides, consisting of an adjacent enamine bonding site (Bronsted base site), a hydrogen bonding site (Bronsted acid site), and flexible…”
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Pattern of item score change in Stroke Impairment Assessment Set in comprehensive inpatient rehabilitation wards by Yagihashi, Kei, Sonoda, Shigeru, Watanabe, Makoto, Okamoto, Sayaka, Okuyama, Yuko, Okazaki, Hideto

“…Objectives: Although numerous studies have examined activities of daily living (ADL) in stroke rehabilitation, there has been little focus on impairment,…”
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Breakpoint Cluster Region-Mediated Inflammation Is Dependent on Casein Kinase II by Meng, Jie, Jiang, Jing-Jing, Atsumi, Toru, Bando, Hidenori, Okuyama, Yuko, Sabharwal, Lavannya, Nakagawa, Ikuma, Higuchi, Haruka, Ota, Mitsutoshi, Okawara, Momoko, Ishitani, Ryuichiro, Nureki, Osamu, Higo, Daisuke, Arima, Yasunobu, Ogura, Hideki, Kamimura, Daisuke, Murakami, Masaaki

“…The breakpoint cluster region (BCR) is known as a kinase and cause of leukemia upon fusing to Abl kinase. In this study, we demonstrate that BCR associated…”
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Biallelic variants/mutations of IL1RAP in patients with steroid-sensitive nephrotic syndrome by Niitsuma, Sou, Kudo, Hiroki, Kikuchi, Atsuo, Hayashi, Takaya, Kumakura, Satoshi, Kobayashi, Shuhei, Okuyama, Yuko, Kumagai, Naonori, Niihori, Tetsuya, Aoki, Yoko, So, Takanori, Funayama, Ryo, Nakayama, Keiko, Shirota, Matsuyuki, Kondo, Shuji, Kagami, Shoji, Tsukaguchi, Hiroyasu, Iijima, Kazumoto, Kure, Shigeo, Ishii, Naoto

“…Abstract Nephrotic syndrome (NS) is a renal disease characterized by severe proteinuria and hypoproteinemia. Although several single-gene mutations have been…”
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Disease-Association Analysis of an Inflammation-Related Feedback Loop by Murakami, Masaaki, Harada, Masaya, Kamimura, Daisuke, Ogura, Hideki, Okuyama, Yuko, Kumai, Noriko, Okuyama, Azusa, Singh, Rajeev, Jiang, Jing-Jing, Atsumi, Toru, Shiraya, Sayaka, Nakatsuji, Yuji, Kinoshita, Makoto, Kohsaka, Hitoshi, Nishida, Makoto, Sakoda, Saburo, Miyasaka, Nobuyuki, Yamaguchi-Takihara, Keiko, Hirano, Toshio

“…The IL-6-triggered positive feedback loop for NFκB signaling (or the IL-6 amplifier/Inflammation amplifier) was originally discovered as a…”
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Mesenteric lymph nodes contribute to proinflammatory Th17‐cell generation during inflammation of the small intestine in mice by Kawabe, Takeshi, Suzuki, Nobu, Yamaki, Satoshi, Sun, Shu‐lan, Asao, Atsuko, Okuyama, Yuko, So, Takanori, Iwakura, Yoichiro, Ishii, Naoto

“…T cells of the small intestine, including Th17 cells, are critically involved in host protection from microbial infection, and also contribute to the…”
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IL-6 positively regulates Foxp3+CD8+ T cells in vivo by Nakagawa, Takayuki, Tsuruoka, Mineko, Ogura, Hideki, Okuyama, Yuko, Arima, Yasunobu, Hirano, Toshio, Murakami, Masaaki

“…Although recent studies have identified regulatory roles for Foxp3+CD8+ T cells, the mechanisms that induce their development and underlie their functions in…”
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Correction: Breakpoint Cluster Region-Mediated Inflammation Is Dependent on Casein Kinase II by Meng, Jie, Jiang, Jing-Jing, Atsumi, Toru, Bando, Hidenori, Okuyama, Yuko, Sabharwal, Lavannya, Nakagawa, Ikuma, Higuchi, Haruka, Ota, Mitsutoshi, Okawara, Momoko, Ishitani, Ryuichiro, Nureki, Osamu, Higo, Daisuke, Arima, Yasunobu, Ogura, Hideki, Kamimura, Daisuke, Murakami, Masaaki

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An efficient synthetic methodology of chiral isoquinuclidines by the enantioselective Diels–Alder reaction of 1,2-dihydropyridines using chiral cationic palladium–phosphinooxazolidine catalyst by Nakano, Hiroto, Tsugawa, Natsumi, Takahashi, Kouichi, Okuyama, Yuko, Fujita, Reiko

“…High purity chiral isoquinuclidines (97% ee) were obtained from the enantioselective Diels–Alder reaction of 1-phenoxycarbonyl-1,2-dihydropyridine with…”
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