Search Results - "OKAZAKI, Taku"

PD-1 and PD-1 ligands: from discovery to clinical application by Okazaki, Taku, Honjo, Tasuku

“…Programmed cell death-1 (PD-1, Pdcd1), an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting…”
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Restriction of PD-1 function by cis -PD-L1/CD80 interactions is required for optimal T cell responses by Sugiura, Daisuke, Maruhashi, Takumi, Okazaki, Il-Mi, Shimizu, Kenji, Maeda, Takeo K, Takemoto, Tatsuya, Okazaki, Taku

“…Targeted blockade of PD-1 with immune checkpoint inhibitors can activate T cells to destroy tumors. PD-1 is believed to function mainly at the effector, but…”
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LAG-3: from molecular functions to clinical applications by Maruhashi, Takumi, Sugiura, Daisuke, Okazaki, Il-Mi, Okazaki, Taku

“…To prevent the destruction of tissues owing to excessive and/or inappropriate immune responses, immune cells are under strict check by various regulatory…”
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The PD-1–PD-L pathway in immunological tolerance by Okazaki, Taku, Honjo, Tasuku

“…Since the first observation of spontaneous autoimmune diseases in programmed cell death 1 (PD-1) knockout mice, PD-1 has been postulated to have essential…”
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PD-1 deficiency results in the development of fatal myocarditis in MRL mice by Wang, Jian, Okazaki, Il-mi, Yoshida, Taku, Chikuma, Shunsuke, Kato, Yu, Nakaki, Fumio, Hiai, Hiroshi, Honjo, Tasuku, Okazaki, Taku

“…The deficiency of programmed cell death 1 (PD-1, Pdcd1), a negative immuno-receptor belonging to the CD28/cytotoxic T lymphocyte antigen 4 (CTLA-4) family, can…”
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PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation by Mizuno, Reina, Sugiura, Daisuke, Shimizu, Kenji, Maruhashi, Takumi, Watada, Mizuki, Okazaki, Il-Mi, Okazaki, Taku

“…Cancer-immunotherapy targeting programmed cell death 1 (PD-1) activates tumor-specific T cells and provides clinical benefits in various cancers. However, the…”
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Tumor cell expression of programmed cell death‐1 ligand 1 is a prognostic factor for malignant melanoma by Hino, Ryosuke, Kabashima, Kenji, Kato, Yu, Yagi, Hiroaki, Nakamura, Motonobu, Honjo, Tasuku, Okazaki, Taku, Tokura, Yoshiki

“…BACKGROUND: Melanoma tends to be refractory to various immunotherapies because of tumor‐induced immunosuppression. To investigate the mechanism underlining the…”
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PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity by Sugiura, Daisuke, Okazaki, Il-mi, Maeda, Takeo K., Maruhashi, Takumi, Shimizu, Kenji, Arakaki, Rieko, Takemoto, Tatsuya, Ishimaru, Naozumi, Okazaki, Taku

“…Targeted blockade of the checkpoint molecule programmed cell death 1 (PD-1) can activate tumor-specific T cells to destroy tumors, whereas targeted…”
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A battle between two biological singularities: Immune response vs. cancer by Katakai, Tomoya, Okazaki, Taku

“…In a post-growth multicellular organism, the phenomenon in which a small number of rare cells can be the starting point for inducing a dramatic change in the…”
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T-cell-intrinsic and -extrinsic regulation of PD-1 function by Sugiura, Daisuke, Shimizu, Kenji, Maruhashi, Takumi, Okazaki, Il-mi, Okazaki, Taku

“…Abstract Cancer immunotherapies that target PD-1 (programmed cell death 1) aim to destroy tumors by activating tumor-specific T cells that are otherwise…”
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Programmed cell death 1 ligand 1 and tumor-infiltrating CD8⁺ T lymphocytes are prognostic factors of human ovarian cancer by Hamanishi, Junzo, Mandai, Masaki, Iwasaki, Masashi, Okazaki, Taku, Tanaka, Yoshimasa, Yamaguchi, Ken, Higuchi, Toshihiro, Yagi, Haruhiko, Takakura, Kenji, Minato, Nagahiro, Honjo, Tasuku, Fujii, Shingo

“…The ligands for programmed cell death 1 (PD-1), an immunoinhibitory receptor belonging to CD28/cytotoxic T lymphocyte antigen 4 family, are PD-1 ligand 1 and 2…”
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PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice by Okazaki, Taku, Okazaki, Il-mi, Wang, Jian, Sugiura, Daisuke, Nakaki, Fumio, Yoshida, Taku, Kato, Yu, Fagarasan, Sidonia, Muramatsu, Masamichi, Eto, Tomoo, Hioki, Kyoji, Honjo, Tasuku

“…Stimulatory and inhibitory co-receptors play fundamental roles in the regulation of the immune system. We describe a new mouse model of spontaneous autoimmune…”
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Involvement of PD-L1 on Tumor Cells in the Escape from Host Immune System and Tumor Immunotherapy by PD-L1 Blockade by Iwai, Yoshiko, Ishida, Masayoshi, Tanaka, Yoshimasa, Okazaki, Taku, Honjo, Tasuku, Minato, Nagahiro

“…PD-1 is a receptor of the Ig superfamily that negatively regulates T cell antigen receptor signaling by interacting with the specific ligands (PD-L) and is…”
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PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors by Lin, David Yin-wei, Tanaka, Yoshimasa, Iwasaki, Masashi, Gittis, Apostolos G, Su, Hua-Poo, Mikami, Bunzo, Okazaki, Taku, Honjo, Tasuku, Minato, Nagahiro, Garboczi, David N

“…Signaling through the programmed death 1 (PD-1) inhibitory receptor upon binding its ligand, PD-L1, suppresses immune responses against autoantigens and tumors…”
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Establishment of NOD-Pdcd1-/-Mice as an Efficient Animal Model of Type I Diabetes by Wang, Jian, Yoshida, Taku, Nakaki, Fumio, Hiai, Hiroshi, Okazaki, Taku, Honjo, Tasuku

“…Mice deficient in programmed cell death 1 (PD-1, Pdcd1), an immunoinhibitory receptor belonging to the CD28/cytotoxic T lymphocyte-associated antigen-4 family,…”
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Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis by Kayama, Hisako, Ueda, Yoshiyasu, Sawa, Yukihisa, Jeon, Seong Gyu, Ma, Ji Su, Okumura, Ryu, Kubo, Atsuko, Ishii, Masaru, Okazaki, Taku, Murakami, Masaaki, Yamamoto, Masahiro, Yagita, Hideo, Takeda, Kiyoshi

“…Adequate activation of CD4+ T lymphocytes is essential for host defense against invading pathogens; however, exaggerated activity of effector CD4+ T cells…”
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PD-1 Immunoreceptor Inhibits B Cell Receptor-Mediated Signaling by Recruiting Src Homology 2-Domain-Containing Tyrosine Phosphatase 2 to Phosphotyrosine by Okazaki, Taku, Maeda, Akito, Nishimura, Hiroyuki, Kurosaki, Tomohiro, Honjo, Tasuku

“…PD-1 is an immunoreceptor that belongs to the immunoglobulin (Ig) superfamily and contains two tyrosine residues in the cytoplasmic region. Studies on…”
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Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice by Honjo, Tasuku, Okazaki, Taku, Tanaka, Yoshimasa, Nishio, Ryosuke, Mitsuiye, Tamotsu, Mizoguchi, Akira, Wang, Jian, Ishida, Masayoshi, Hiai, Hiroshi, Matsumori, Akira, Minato, Nagahiro

“…We recently reported that mice deficient in the programmed cell death-1 (PD-1) immunoinhibitory coreceptor develop autoimmune dilated cardiomyopathy (DCM),…”
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PD-1 inhibits antiviral immunity at the effector phase in the liver by Iwai, Yoshiko, Terawaki, Seigo, Ikegawa, Masaya, Okazaki, Taku, Honjo, Tasuku

“…Unlike naive T cells, effector T cells can be activated by either T cell receptor signal or costimulatory signal alone and therefore the absence of…”
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New regulatory co-receptors: inducible co-stimulator and PD-1 by Okazaki, Taku, Iwai, Yoshiko, Honjo, Tasuku

“…Autoreactive lymphocytes are suppressed in healthy individuals by so-called peripheral tolerance. Accumulating evidence indicates that co-receptor signaling…”
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