Search Results - "OKAJIMA, F"

Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions by Murata, N, Sato, K, Kon, J, Tomura, H, Yanagita, M, Kuwabara, A, Ui, M, Okajima, F

“…The concentration of sphingosine 1-phosphate (S1P) in plasma or serum is much higher than the half-maximal concentration of the sphingolipid needed to…”
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Clinical implication of apolipoprotein m: apolipoprotein m may be a biomarker of coagulation and fibrinolysis by Aoki, T, Kimura, T, Simizu, T, Sumino, H, Miyazaki, O, Fukamachi, I, Nakajima, K, Okajima, F, Murakami, M

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Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells by Tamama, K, Kon, J, Sato, K, Tomura, H, Kuwabara, A, Kimura, T, Kanda, T, Ohta, H, Ui, M, Kobayashi, I, Okajima, F

“…Exogenous sphingosine 1-phosphate (S1P) increased cytosolic Ca(2+) concentration, stimulated thymidine incorporation (DNA synthesis) and inhibited cell…”
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Sensitized Mast Cells Migrate Toward the Agen: A Response Regulated by p38 Mitogen-Activated Protein Kinase and Rho-Associated Coiled-Coil-Forming Protein Kinase by Ishizuka, Tamotsu, Okajima, Fumikazu, Ishiwara, Mitsuteru, Iizuka, Kunihiko, Ichimonji, Isao, Kawata, Tadayoshi, Tsukagoshi, Hideo, Dobashi, Kunio, Nakazawa, Tsugio, Mori, Masatomo

“…Although mast cells accumulate within the mucosal epithelial layer of patients with allergic rhinitis and bronchial asthma, the responsible chemotactic factors…”
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Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator? by Okajima, Fumikazu

“…Sphingosine 1-phosphate (S1P) concentration in plasma and serum has been estimated to be within 200–900 nM. Among plasma and serum components, S1P is…”
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A non-acromegalic case of multiple endocrine neoplasia type 1 accompanied by a growth hormone-releasing hormone-producing pancreatic tumor by Sugihara, H, Shibasaki, T, Tatsuguchi, A, Okajima, F, Wakita, S, Nakajima, Y, Tanimura, K, Tamura, H, Ishii, S, Kamegai, J, Akasu, H, Kitagawa, W, Shimizu, K, Nakamura, Y, Uchida, E, Tajiri, T, Naito, Z, Katakami, H, Oikawa, S

“…Cases of acromegaly due to GHRHproducing pancreatic endocrine tumors have been reported. Here we present a case of a 31-yr-old nonacromegalic man with…”
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Enkephalin activates the phospholipase C/Ca2+ system through cross-talk between opioid receptors and P2-purinergic or bradykinin receptors in NG 108-15 cells : a permissive role for pertussis toxin-sensitive G-proteins by OKAJIMA, F, TOMURA, H, KONDO, Y

“…In an NG 108-15 neuroblastoma x glioma hybrid cell suspension, extracellular ATP (via P2-purinergic receptors) and bradykinin stimulated Ins(1,4,5)P3…”
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Inhibition by islet-activating protein, pertussis toxin, of P2-purinergic receptor-mediated iodide efflux and phosphoinositide turnover in FRTL-5 cells by Okajima, F, Sho, K, Kondo, Y

“…Exposure of FRTL-5 thyroid cells to ATP (1 microM to 1 mM) resulted in the stimulation of I- efflux in association with the induction of inositol trisphosphate…”
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Mutation of alanine 623 in the third cytoplasmic loop of the rat thyrotropin (TSH) receptor results in a loss in the phosphoinositide but not cAMP signal induced by TSH and receptor autoantibodies by KOSUGI, S, OKAJIMA, F, BAN, T, HIDAKA, A, SHENKER, A, KOHN, L. D

“…Thyrotropin (TSH) and IgG preparations from patients with Graves' disease increase inositol phosphate as well as cAMP formation in Cos-7 cells transfected with…”
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P2-purinergic receptors are coupled to two signal transduction systems leading to inhibition of cAMP generation and to production of inositol trisphosphate in rat hepatocytes by Okajima, F, Tokumitsu, Y, Kondo, Y, Ui, M

“…Stimulation of P2-purinergic receptors by ATP resulted in activation of phosphorylase, which was associated with marked production of inositol trisphosphate…”
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Growth inhibition of human pancreatic cancer cells by sphingosylphosphorylcholine and influence of culture conditions by Yamada, T, Okajima, F, Ohwada, S, Kondo, Y

“…Sphingosylphosphorylcholine (SPC) has been shown to be a potent mitogen for Swiss 3T3 fibroblasts and also to be an inhibitor of cell growth of some cancer…”
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Reciprocal modulation of thyrotropin actions by P1-purinergic agonists in FRTL-5 thyroid cells. Inhibition of cAMP pathway and stimulation of phospholipase C-Ca2+ pathway by SHO, K, OKAJIMA, F, MOHAMMED ABDUL MAJID, KONDO, Y

“…In FRTL-5 thyroid cells, thyrotropin (TSH) stimulates I- efflux in association with phospholipase C activation and Ca2+ mobilization. TSH also stimulates DNA…”
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PTHrP increases pancreatic β-cell-specific functions in well-differentiated cells by Sawada, Yoshie, Zhang, Bin, Okajima, Fumikazu, Izumi, Tetsuro, Takeuchi, Toshiyuki

“…Parathyroid hormone-related protein (PTHrP) is reportedly produced in normal islets and insulinomas. PTHrP induces differentiation in some cell-types and…”
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A permissive role of pertussis toxin substrate G-protein in P2-purinergic stimulation of phosphoinositide turnover and arachidonate release in FRTL-5 thyroid cells. Cooperative mechanism of signal transduction systems by OKAJIMA, F, SATO, K, NAZAREA, M, SHO, K, KONDO, Y

“…Extracellular ATP and other purinergic agonists were found to inhibit cAMP accumulation by depressing adenylate cyclase as an "inhibitory action" and/or to…”
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Establishment of the method for the measurement of sphingosine-1-phosphate in biological samples and its application for S1P research by Okajima, F

“…Sphingosine 1-phosphate (S1P), one of the sphingolipid metabolites, has been shown to participate in a variety of cellular responses including proliferation,…”
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Extracellular ATP stimulates three different receptor-signal transduction systems in FRTL-5 thyroid cells : activation of phospholipase C, and inhibition and activation of adenylate cyclase by SATO, K, OKAJIMA, F, KONDO, Y

“…In FRTL-5 thyroid cells, extracellular ATP, a P2-agonist, not only stimulates phospholipase C but also inhibits forskolin- or thyrotropin (TSH)-induced…”
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A single species of A1 adenosine receptor expressed in Chinese hamster ovary cells not only inhibits cAMP accumulation but also stimulates phospholipase C and arachidonate release by Akbar, M, Okajima, F, Tomura, H, Shimegi, S, Kondo, Y

“…Chinese hamster ovary cells were transfected with both A1 adenosine receptor and muscarinic type 3 acetylcholine receptor cDNAs. The muscarinic receptor…”
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Transfected human somatostatin receptor type 2, SSTR2, not only inhibits adenylate cyclase but also stimulates phospholipase C and Ca2+ mobilization by Tomura, H, Okajima, F, Akbar, M, Abdul Majid, M, Sho, K, Kondo, Y

“…COS-7 cells were transfected with human somatostatin (SRIF) receptor type 1 and 2 (human SSTR1 and SSTR2, respectively) cDNAs. In human SSTR2-expressing cells,…”
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Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: A novel type of multi-functional receptors by Tomura, Hideaki, Mogi, Chihiro, Sato, Koichi, Okajima, Fumikazu

“…OGR1, GPR4, G2A, and TDAG8 share 40% to 50% homology with each other and seem to form a family of GPCRs. They have been described as receptors for lipid…”
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Frequency of achilles tendon xanthoma in patients with acute coronary syndrome by Oikawa, S., Harada, T., Inagaki-Tanimura, K., Nagao, M., Sato, Y., Sudo, M., Okajima, F., Sugihara, H.

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