Search Results - "OKABE, Takafumi"

B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity by Yonesaka, Kimio, Haratani, Koji, Takamura, Shiki, Sakai, Hitomi, Kato, Ryoji, Takegawa, Naoki, Takahama, Takayuki, Tanaka, Kaoru, Hayashi, Hidetoshi, Takeda, Masayuki, Kato, Sigeki, Maenishi, Osamu, Sakai, Kazuko, Chiba, Yasutaka, Okabe, Takafumi, Kudo, Keita, Hasegawa, Yoshikazu, Kaneda, Hiroyasu, Yamato, Michiko, Hirotani, Kenji, Miyazawa, Masaaki, Nishio, Kazuto, Nakagawa, Kazuhiko

“…Anti-programmed-death-1 (PD-1) immunotherapy improves survival in non-small cell lung cancer (NSCLC), but some cases are refractory to treatment, thereby…”
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Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab by Yonesaka, Kimio, Zejnullahu, Kreshnik, Okamoto, Isamu, Satoh, Taroh, Cappuzzo, Federico, Souglakos, John, Ercan, Dalia, Rogers, Andrew, Roncalli, Massimo, Takeda, Masayuki, Fujisaka, Yasuhito, Philips, Juliet, Shimizu, Toshio, Maenishi, Osamu, Cho, Yonggon, Sun, Jason, Destro, Annarita, Taira, Koichi, Takeda, Koji, Okabe, Takafumi, Swanson, Jeffrey, Itoh, Hiroyuki, Takada, Minoru, Lifshits, Eugene, Okuno, Kiyotaka, Engelman, Jeffrey A, Shivdasani, Ramesh A, Nishio, Kazuto, Fukuoka, Masahiro, Varella-Garcia, Marileila, Nakagawa, Kazuhiko, Jänne, Pasi A

“…Cetuximab, an antibody directed against the epidermal growth factor receptor, is an effective clinical therapy for patients with colorectal, head and neck, and…”
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Activation of HER Family Signaling as a Mechanism of Acquired Resistance to ALK Inhibitors in EML4-ALK―Positive Non―Small Cell Lung Cancer by TANIZAKI, Junko, OKAMOTO, Isamu, HATASHITA, Erina, NISHIO, Kazuto, NAKAGAWA, Kazuhiko, OKABE, Takafumi, SAKAI, Kazuko, TANAKA, Kaoru, HAYASHI, Hidetoshi, KANEDA, Hiroyasu, TAKEZAWA, Ken, KUWATA, Kiyoko, YAMAGUCHI, Haruka

“…Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKI) such as crizotinib show marked efficacy in patients with non-small cell lung cancer positive…”
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Tyrosine Phosphoproteomics Identifies Both Codrivers and Cotargeting Strategies for T790M-Related EGFR-TKI Resistance in Non-Small Cell Lung Cancer by YOSHIDA, Takeshi, GUOLIN ZHANG, CHEN, Ann Y, KITANO, Michiko, MORITA, Yume, YAMAGUCHI, Haruka, SHIBATA, Kiyoko, OKABE, Takafumi, OKAMOTO, Isamu, NAKAGAWA, Kazuhiko, HAURA, Eric B, SMITH, Matthew A, LOPEZ, Alex S, YUN BAI, JIANNONG LI, BIN FANG, KOOMEN, John, RAWAL, Bhupendra, FISHER, Kate J

“…Irreversible EGFR-tyrosine kinase inhibitors (TKI) are thought to be one strategy to overcome EGFR-TKI resistance induced by T790M gatekeeper mutations in…”
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Production of functional eggs and sperm from in vitro-expanded type A spermatogonia in rainbow trout by Iwasaki-Takahashi, Yoshiko, Shikina, Shinya, Watanabe, Masaya, Banba, Akira, Yagisawa, Masaru, Takahashi, Kasumi, Fujihara, Ryo, Okabe, Takafumi, Valdez Jr, Delgado M., Yamauchi, Akihiro, Yoshizaki, Goro

“…Combining cryopreservation of germline stem cells (GSCs) with their subsequent transplantation into recipient fish is a powerful tool for long-term…”
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In vivo and in vitro anti-obesity activities of dihydropyranocoumarins derivatives from Peucedanum japonicum Thunb by Taira, Naoyuki, Nugara, Ruwani N., Inafuku, Masashi, Takara, Kensaku, Ogi, Takayuki, Ichiba, Toshio, Iwasaki, Hironori, Okabe, Takafumi, Oku, Hirosuke

“…•We identified two varieties of Peucedanum japonicum Thunb (PJT).•Dietary coumarin concentrates from two varieties of PJT inhibited obesity.•Several coumarins…”
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Peucedanum japonicum Thunb Inhibits High-fat Diet Induced Obesity in Mice by Okabe, Takafumi, Toda, Takayoshi, Nukitrangsan, Natthanan, Inafuku, Masashi, Iwasaki, Hironori, Oku, Hirosuke

“…This study examined the antiobese activity of Peucedanum japonicum Thunb (PJT) in mice. In the first experiment, 4-week-old C57BL/6 mice were fed seven…”
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Matuzumab and cetuximab activate the epidermal growth factor receptor but fail to trigger downstream signaling by Akt or Erk by Yoshida, Takeshi, Okamoto, Isamu, Okabe, Takafumi, Iwasa, Tsutomu, Satoh, Taroh, Nishio, Kazuto, Fukuoka, Masahiro, Nakagawa, Kazuhiko

“…Molecular inhibition of the epidermal growth factor receptor (EGFR) is a promising anticancer strategy, and monoclonal antibodies (mAbs) to EGFR are undergoing…”
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Phase I trial of OTS11101, an anti‐angiogenic vaccine targeting vascular endothelial growth factor receptor 1 in solid tumor by Hayashi, Hidetoshi, Kurata, Takayasu, Fujisaka, Yasuhito, Kawakami, Hisato, Tanaka, Kaoru, Okabe, Takafumi, Takeda, Masayuki, Satoh, Taroh, Yoshida, Koji, Tsunoda, Takuya, Arao, Tokuzo, Nishio, Kazuto, Nakagawa, Kazuhiko

“…OTS11101 is a novel peptide vaccine that acts as an angiogenesis inhibitor by inducing cytotoxic T lymphocyte (CTL) cells that specifically target vascular…”
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Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: role of gefitinib-induced down-regulation of thymidylate synthase by Okabe, Takafumi, Okamoto, Isamu, Tsukioka, Sayaka, Uchida, Junji, Iwasa, Tsutomu, Yoshida, Takeshi, Hatashita, Erina, Yamada, Yuki, Satoh, Taroh, Tamura, Kenji, Fukuoka, Masahiro, Nakagawa, Kazuhiko

“…Somatic mutations in the epidermal growth factor receptor ( EGFR ) gene are associated with the therapeutic response to EGFR tyrosine kinase inhibitors (TKI)…”
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Effect of Peucedanum japonicum Thunb Extract on High-fat Diet-induced Obesity and Gene Expression in Mice by Nukitrangsan, Natthanan, Okabe, Takafumi, Toda, Takayoshi, Inafuku, Masashi, Iwasaki, Hironori, Oku, Hirosuke

“…Supplementation of the diet with Peucedanum japonicum Thunb (PJT) powder inhibits high-fat diet-induced obesity in mice. Either the fiber component or other…”
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Addition of S-1 to the Epidermal Growth Factor Receptor Inhibitor Gefitinib Overcomes Gefitinib Resistance in Non–small cell Lung Cancer Cell Lines with MET Amplification by Okabe, Takafumi, Okamoto, Isamu, Tsukioka, Sayaka, Uchida, Junji, Hatashita, Erina, Yamada, Yuki, Yoshida, Takeshi, Nishio, Kazuto, Fukuoka, Masahiro, Jänne, Pasi A, Nakagawa, Kazuhiko

“…Purpose: Most non–small cell lung cancer (NSCLC) tumors with activating mutations in the epidermal growth factor receptor (EGFR) are initially responsive to…”
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Tumor-selective cytotoxicity of benzo[c]phenanthridine derivatives from Toddalia asiatica Lam by Iwasaki, Hironori, Okabe, Takafumi, Takara, Kensaku, Toda, Takayoshi, Shimatani, Masayuki, Oku, Hirosuke

“…Purpose To develop a novel anti-cancer drug of low side effect against lung adenocarcinoma, the authors screened the bioresources of Okinawa Island, Japan. The…”
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Antiatherosclerotic Function of Kokuto, Okinawan Noncentrifugal Cane Sugar by Okabe, Takafumi, Toda, Takayoshi, Inafuku, Masashi, Wada, Koji, Iwasaki, Hironori, Oku, Hirosuke

“…In the present study, we investigated the effect of phenolic compounds (PCs) and policosanol of Kokuto, Okinawan noncentrifugal cane sugar, on the development…”
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Effect of Peucedanum japonicum Thunb on the Expression of Obesity-Related Genes in Mice on a High-Fat Diet by Nukitrangsan, Natthanan, Okabe, Takafumi, Toda, Takayoshi, Inafuku, Masashi, Iwasaki, Hironori, Yanagita, Teruyoshi, Oku, Hirosuke

“…The present study describes the effect of Peucedanum japonicum Thunb (PJT) intake on the expression of obesity-related genes in mice fed a high-fat diet. To…”
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Molecular cloning and functional expression of a multifunctional triterpene synthase cDNA from a mangrove species Kandelia candel (L.) Druce by Basyuni, Mohammad, Oku, Hirosuke, Inafuku, Masashi, Baba, Shigeyuki, Iwasaki, Hironori, Oshiro, Keichiro, Okabe, Takafumi, Shibuya, Masaaki, Ebizuka, Yutaka

“…An oxidosqualene cyclase homologue was cloned from Kandelia candel (L.) Druce, and identified as a multifunctional triterpene synthase able to produce lupeol,…”
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Association of tumour burden with the efficacy of programmed cell death-1/programmed cell death ligand-1 inhibitors for treatment-naïve advanced non-small-cell lung cancer by Suzuki, Shinichiro, Haratani, Koji, Hayashi, Hidetoshi, Chiba, Yasutaka, Tanizaki, Junko, Kato, Ryoji, Mitani, Seiichiro, Kawanaka, Yusuke, Kurosaki, Takashi, Hasegawa, Yoshikazu, Okabe, Takafumi, Tanaka, Kaoru, Akashi, Yusaku, Ozaki, Tomohiro, Nishio, Kazuto, Ito, Akihiko, Nakagawa, Kazuhiko

“…Tumour burden (TB) is implicated in resistance to programmed cell death-1/PD-L1 inhibitor (immune checkpoint inhibitor [ICI]) therapy. However, whether TB…”
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MO28-4 Multi-disciplinary collaboration on gene panel testing and review of factors in cases of unsuitable for gene profiling by Takahama, Takayuki, Ichimura, Noriko, Okabe, Takafumi, Akashi, Yusaku, Tamura, Takao, Shimoyoshi, Miyako, Kameda, Keisuke, Wakasa, Tomoko, Ohta, Yoshio, Yamada, Hidekazu, Yukawa, Masao

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Impact of First-Line Osimertinib and Other EGFR-Tyrosine Kinase Inhibitors on Overall Survival in Untreated Advanced EGFR-Mutated Non-small Cell Lung Cancer in Japan: Updated Data from TREAD Project 01 by Hibino, Makoto, Imamura, Yoshinori, Shimoyama, Rai, Fukui, Tomoya, Fukai, Ryuta, Iwase, Akihiko, Tamura, Yukihiro, Chihara, Yusuke, Okabe, Takafumi, Uryu, Kiyoaki, Okuda, Tadahisa, Taguri, Masataka, Minami, Hironobu

“…Background Osimertinib shows higher effectiveness than first-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) in the…”
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Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification by OKABE, Takafumi, OKAMOTO, Isamu, TAMURA, Kenji, TERASHIMA, Masaaki, YOSHIDA, Takeshi, SATOH, Taroh, TAKADA, Minoru, FUKUOKA, Masahiro, NAKAGAWA, Kazuhiko

“…The identification of somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) in patients with non-small cell lung…”
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