Search Results - "OJEDA, Sergio R"

Preclinical Differences of Intravascular AAV9 Delivery to Neurons and Glia: A Comparative Study of Adult Mice and Nonhuman Primates by Gray, Steven J, Matagne, Valerie, Bachaboina, Lavanya, Yadav, Swati, Ojeda, Sergio R, Samulski, R Jude

“…Other labs have previously reported the ability of adeno-associated virus serotype 9 (AAV9) to cross the blood-brain barrier (BBB). In this report, we…”
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Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty by Toro, Carlos A., Wright, Hollis, Aylwin, Carlos F., Ojeda, Sergio R., Lomniczi, Alejandro

“…Polycomb group (PcG) proteins control the timing of puberty by repressing the Kiss1 gene in hypothalamic arcuate nucleus (ARC) neurons. Here we identify two…”
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Polycomb represses a gene network controlling puberty via modulation of histone demethylase Kdm6b expression by Wright, Hollis, Aylwin, Carlos F., Toro, Carlos A., Ojeda, Sergio R., Lomniczi, Alejandro

“…Female puberty is subject to Polycomb Group (PcG)-dependent transcriptional repression. Kiss1 , a puberty-activating gene, is a key target of this silencing…”
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Kisspeptin Receptor Haplo-insufficiency Causes Premature Ovarian Failure Despite Preserved Gonadotropin Secretion by Gaytan, Francisco, Garcia-Galiano, David, Dorfman, Mauricio D, Manfredi-Lozano, Maria, Castellano, Juan M, Dissen, Gregory A, Ojeda, Sergio R, Tena-Sempere, Manuel

“…Premature ovarian failure (POF) affects 1% of women in reproductive age, but its etiology remains uncertain. Whereas kisspeptins, the products of Kiss1 that…”
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Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression by Lomniczi, Alejandro, Wright, Hollis, Castellano, Juan Manuel, Matagne, Valerie, Toro, Carlos A., Ramaswamy, Suresh, Plant, Tony M., Ojeda, Sergio R.

“…In primates, puberty is unleashed by increased GnRH release from the hypothalamus following an interval of juvenile quiescence. GWAS implicates Zinc finger (…”
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Increased Hypothalamic GPR54 Signaling: A Potential Mechanism for Initiation of Puberty in Primates by Shahab, Muhammad, Mastronardi, Claudio, Seminara, Stephanie B., Crowley, William F., Ojeda, Sergio R., Plant, Tony M., Grumbach, Melvin M.

“…To further study the role of GPR54 signaling in the onset of primate puberty, we used the monkey to examine the ability of kisspeptin-10 to elicit the release…”
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Elucidating the genetic architecture of reproductive ageing in the Japanese population by Horikoshi, Momoko, Day, Felix R., Akiyama, Masato, Hirata, Makoto, Kamatani, Yoichiro, Matsuda, Koichi, Ishigaki, Kazuyoshi, Kanai, Masahiro, Wright, Hollis, Toro, Carlos A., Ojeda, Sergio R., Lomniczi, Alejandro, Kubo, Michiaki, Ong, Ken K., Perry, John. R. B.

“…Population studies elucidating the genetic architecture of reproductive ageing have been largely limited to European ancestries, restricting the…”
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Loss of Ntrk2/Kiss1r Signaling in Oocytes Causes Premature Ovarian Failure by Dorfman, Mauricio D, Garcia-Rudaz, Cecilia, Alderman, Zefora, Kerr, Bredford, Lomniczi, Alejandro, Dissen, Gregory A, Castellano, Juan Manuel, Garcia-Galiano, David, Gaytan, Francisco, Xu, Baoji, Tena-Sempere, Manuel, Ojeda, Sergio R

“…Neurotrophins (NTs), once believed to be neural-specific trophic factors, are now known to also provide developmental cues to non-neural cells. In the ovary,…”
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Contribution of glial-neuronal interactions to the neuroendocrine control of female puberty by Ojeda, Sergio R., Lomniczi, Alejandro, Sandau, Ursula

“…Mammalian puberty is initiated by an increased pulsatile release of the neuropeptide gonadotropin‐releasing hormone (GnRH) from hypothalamic neuroendocrine…”
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Environmental Factors and Puberty Timing: Expert Panel Research Needs by Buck Louis, Germaine M, Gray, L. Earl, Jr, Marcus, Michele, Ojeda, Sergio R, Pescovitz, Ora H, Witchel, Selma Feldman, Sippell, Wolfgang, Abbott, David H, Soto, Ana, Tyl, Rochelle W, Bourguignon, Jean-Pierre, Skakkebaek, Niels E, Swan, Shanna H, Golub, Mari S, Wabitsch, Martin, Toppari, Jorma, Euling, Susan Y

“…Serono Symposia International convened an expert panel to review the impact of environmental influences on the regulation of pubertal onset and progression…”
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Transcriptional Regulatory Role of NELL2 in Preproenkephalin Gene Expression by Ha, Chang Man, Kim, Dong Hee, Lee, Tae Hwan, Kim, Han Rae, Choi, Jungil, Kim, Yoonju, Kang, Dasol, Park, Jeong Woo, Ojeda, Sergio R, Jeong, Jin Kwon, Lee, Byung Ju

“…Preproenkephalin (PPE) is a precursor molecule for multiple endogenous opioid peptides Leu-enkephalin (ENK) and Met-ENK, which are involved in a wide variety…”
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Astrocyte-specific disruption of SynCAM1 signaling results in ADHD-like behavioral manifestations by Sandau, Ursula S, Alderman, Zefora, Corfas, Gabriel, Ojeda, Sergio R, Raber, Jacob

“…SynCAM1 is an adhesion molecule involved in synaptic differentiation and organization. SynCAM1 is also expressed in astroglial cells where it mediates…”
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NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary by Kerr, Bredford, Garcia-Rudaz, Cecilia, Dorfman, Mauricio, Paredes, Alfonso, Ojeda, Sergio R

“…Recent studies have demonstrated that neurotrophins (NTs) and their NTRK tyrosine kinase receptors, thought to be exclusively required for the development of…”
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Hypothalamic EAP1 (Enhanced at Puberty 1) Is Required for Menstrual Cyclicity in Nonhuman Primates by Dissen, Gregory A, Lomniczi, Alejandro, Heger, Sabine, Neff, Tanaya L, Ojeda, Sergio R

“…Mammalian reproductive cyclicity requires the periodic discharge of GnRH from hypothalamic neurons into the portal vessels connecting the neuroendocrine brain…”
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A Novel Transcription Complex That Selectively Modulates Apoptosis of Breast Cancer Cells through Regulation of FASTKD2 by Yeung, Kay T., Das, Sharmistha, Zhang, Jin, Lomniczi, Alejandro, Ojeda, Sergio R., Xu, Chong-Feng, Neubert, Thomas A., Samuels, Herbert H.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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FXYD1 is an MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice by Deng, Vivianne, Matagne, Valerie, Banine, Fatima, Frerking, Matthew, Ohliger, Patricia, Budden, Sarojini, Pevsner, Jonathan, Dissen, Gregory A., Sherman, Larry S., Ojeda, Sergio R.

“…Rett syndrome (RTT) is an X-linked neurodevelopmental disorder linked to heterozygous de novo mutations in the MECP2 gene. MECP2 encodes methyl-CpG-binding…”
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Role of Estradiol in the Dynamic Control of Tanycyte Plasticity Mediated by Vascular Endothelial Cells in the Median Eminence by de Seranno, Sandrine, d'Anglemont de Tassigny, Xavier, Estrella, Cecilia, Loyens, Anne, Kasparov, Sergey, Leroy, Danièle, Ojeda, Sergio R, Beauvillain, Jean-Claude, Prevot, Vincent

“…In the ever-changing physiological context of the neuroendocrine brain, the mechanisms by which cellular events involving neurons, astroglia, and vascular…”
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Methylome profiling of healthy and central precocious puberty girls by Bessa, Danielle S, Maschietto, Mariana, Aylwin, Carlos Francisco, Canton, Ana P M, Brito, Vinicius N, Macedo, Delanie B, Cunha-Silva, Marina, Palhares, Heloísa M C, de Resende, Elisabete A M R, Borges, Maria de Fátima, Mendonca, Berenice B, Netchine, Irene, Krepischi, Ana C V, Lomniczi, Alejandro, Ojeda, Sergio R, Latronico, Ana Claudia

“…Recent studies demonstrated that changes in DNA methylation (DNAm) and inactivation of two imprinted genes (MKRN3 and DLK1) alter the onset of female puberty…”
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Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis by Heger, Sabine, Mastronardi, Claudio, Dissen, Gregory A, Lomniczi, Alejandro, Cabrera, Ricardo, Roth, Christian L, Jung, Heike, Galimi, Francesco, Sippell, Wolfgang, Ojeda, Sergio R

“…The initiation of mammalian puberty and the maintenance of female reproductive cycles are events controlled by hypothalamic neurons that secrete the…”
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Epigenetic regulation of female puberty by Lomniczi, Alejandro, Wright, Hollis, Ojeda, Sergio R

“…Highlights • Female puberty is regulated by epigenetic cues acting at a hypothalamic level. • Epigenetic information influences puberty by modulating gene…”
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