β-tricalcium phosphate and basic fibroblast growth factor combination enhances periodontal regeneration in intrabony defects in dogs

β-tricalcium phosphate and basic fibroblast growth factor combination enhances periodontal regeneration in intrabony defects in dogs

The combined effect of β-tricalcium phosphate and basic fibroblast growth factor was observed in the regeneration of periodontal tissue in dogs. For this purpose, either β-TCP and FGF-2 (β-TCP/FGF-2 group) or FGF-2 alone (FGF-2 group) was applied in intrabony defects. The control group received β-TC...

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Bibliographic Details
Published in:Dental Materials Journal Vol. 28; no. 2; pp. 162 - 169
Main Authors: OI, Yosei, OTA, Mikio, YAMAMOTO, Shigeki, SHIBUKAWA, Yoshihiro, YAMADA, Satoru
Format: Journal Article
Language:English
Published: Japan The Japanese Society for Dental Materials and Devices 2009
Subjects:
Acid Phosphatase - analysis
Alveolar Bone Loss - pathology
Alveolar Bone Loss - surgery
Alveolar Process - pathology
Animals
Basic fibroblast growth factor (FGF-2)
Biomarkers - analysis
Bone Regeneration - physiology
Bone Substitutes - therapeutic use
Calcium Phosphates - therapeutic use
Cementogenesis - physiology
Connective Tissue - pathology
Dental Cementum - pathology
Dentistry
Dog
Dogs
Fibroblast Growth Factor 2 - therapeutic use
Isoenzymes - analysis
Male
Microscopy, Electron, Scanning
Neovascularization, Physiologic - physiology
Osteogenesis - physiology
Porosity
Random Allocation
Surgical Flaps
Tartrate-Resistant Acid Phosphatase
Time Factors
Tissue Scaffolds
Tooth Cervix - pathology
β-tricalcium phosphate (β-TCP)
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Summary:The combined effect of β-tricalcium phosphate and basic fibroblast growth factor was observed in the regeneration of periodontal tissue in dogs. For this purpose, either β-TCP and FGF-2 (β-TCP/FGF-2 group) or FGF-2 alone (FGF-2 group) was applied in intrabony defects. The control group received β-TCP alone. The tissues were histologically examined at 2, 4, or 8 weeks following treatment. The control group was characterized by incomplete, newly formed bone around β-TCP particles. The β-TCP/FGF-2 group showed a statistically significant increase in both new bone and cementum formation compared to the FGF-2-alone group (76.3% vs. 65.3%, p<0.01; 81.0% vs. 68.3%, p<0.01, respectively). These findings suggested that β-TCP may be a suitable scaffold for FGF-2 and that the combination of β-TCP and FGF-2 can enhance bone and cementum formation.
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ISSN:0287-4547
1881-1361
DOI:10.4012/dmj.28.162