Search Results - "OHUCHI, Atsushi"

Autophagy Declines with Premature Skin Aging resulting in Dynamic Alterations in Skin Pigmentation and Epidermal Differentiation by Murase, Daiki, Kusaka-Kikushima, Ayumi, Hachiya, Akira, Fullenkamp, Rachel, Stepp, Anita, Imai, Asuka, Ueno, Mizuki, Kawabata, Keigo, Takahashi, Yoshito, Hase, Tadashi, Ohuchi, Atsushi, Nakamura, Shuhei, Yoshimori, Tamotsu

“…Autophagy is a membrane traffic system that provides sustainable degradation of cellular components for homeostasis, and is thus considered to promote health…”
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The Essential Role of p53 in Hyperpigmentation of the Skin via Regulation of Paracrine Melanogenic Cytokine Receptor Signaling by Murase, Daiki, Hachiya, Akira, Amano, Yasuko, Ohuchi, Atsushi, Kitahara, Takashi, Takema, Yoshinori

“…Hyperpigmentation of the skin is characterized by increases in melanin synthesis and deposition. Although considered a significant psychosocial distress,…”
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The Surprising Effect of Phenformin on Cutaneous Darkening and Characterization of Its Underlying Mechanism by a Forward Chemical Genetics Approach by Takano, Kei, Hachiya, Akira, Murase, Daiki, Kawasaki, Akiko, Uda, Hirokazu, Kasamatsu, Shinya, Sugai, Yoshiya, Takahashi, Yoshito, Hase, Tadashi, Ohuchi, Atsushi, Suzuki, Tamio

“…Melanin in the epidermis is known to ultimately regulate human skin pigmentation. Recently, we exploited a phenotypic-based screening system composed of ex…”
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Alteration of amiloride-sensitive salt taste nerve responses in aldosterone/NaCl-induced hypertensive rats by Sakamoto, Takashi, Fujii, Akihiko, Saito, Naoko, Kondo, Hidehiko, Ohuchi, Atsushi

“…•We studied the mechanism of changes of salt taste sensitivity in hypertensive rats.•Daily sodium intake was high in hypertensive rats.•Amiloride-sensitive…”
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The role of neprilysin in regulating the hair cycle by Morisaki, Naoko, Ohuchi, Atsushi, Moriwaki, Shigeru

“…In most mammals, each hair follicle undergoes a cyclic process of growing, regressing and resting phases (anagen, catagen, telogen, respectively) called the…”
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Comparison of age-related changes in facial wrinkles and sagging in the skin of Japanese, Chinese and Thai women by Tsukahara, Kazue, Sugata, Keiichi, Osanai, Osamu, Ohuchi, Atsushi, Miyauchi, Yuki, Takizawa, Minoru, Hotta, Mitsuyuki, Kitahara, Takashi

“…Summary Background Differences in skin aging features between Asians and Caucasians are commonly known, whereas little is known about such differences in…”
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Essential role of RAB27A in determining constitutive human skin color by Yoshida-Amano, Yasuko, Hachiya, Akira, Ohuchi, Atsushi, Kobinger, Gary P, Kitahara, Takashi, Takema, Yoshinori, Fukuda, Mitsunori

“…Human skin color is predominantly determined by melanin produced in melanosomes within melanocytes and subsequently distributed to keratinocytes. There are…”
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Perilla extract improves frequent urination in spontaneously hypertensive rats with enhancement of the urothelial presence and anti‐inflammatory effects by Kitamura, Naoya, Nishino, Machiko, Fujii, Akihiko, Hashizume, Kohjiro, Nakamura, Junji, Kondo, Hidehiko, Ohuchi, Atsushi, Hase, Tadashi, Murase, Takatoshi

“…Objective To investigate the effects of perilla extract on urinary symptoms in spontaneously hypertensive rats as a model of spontaneous overactive bladder…”
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Ethnic differences in the structural properties of facial skin by Sugiyama-Nakagiri, Yoriko, Sugata, Keiichi, Hachiya, Akira, Osanai, Osamu, Ohuchi, Atsushi, Kitahara, Takashi

“…Summary Background Conspicuous facial pores are one type of serious aesthetic defects for many women. However, the mechanism(s) that underlie the…”
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The Paracrine Role of Stem Cell Factor/c-kit Signaling in the Activation of Human Melanocytes in Ultraviolet-B-Induced Pigmentation by Hachiya, Akira, Kobayashi, Akemi, Ohuchi, Atsushi, Takema, Yoshinori, Imokawa, Genji

“…The interaction of stem cell factor with its receptor, c-kit, is well known to be critical to the survival of melanocytes. Little is known about the role(s) of…”
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Mechanistic Effects of Long-Term Ultraviolet B Irradiation Induce Epidermal and Dermal Changes in Human Skin Xenografts by Hachiya, Akira, Sriwiriyanont, Penkanok, Fujimura, Tsutomu, Ohuchi, Atsushi, Kitahara, Takashi, Takema, Yoshinori, Kitzmiller, William J, Visscher, Marty O, Tsuboi, Ryoji, Boissy, Raymond E

“…UVB irradiation has been reported to induce photoaging and suppress systemic immune function that could lead to photocarcinogenesis. However, because of the…”
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Functional analysis of keratinocytes in skin color using a human skin substitute model composed of cells derived from different skin pigmentation types by Yoshida, Yasuko, Hachiya, Akira, Sriwiriyanont, Penkanok, Ohuchi, Atsushi, Kitahara, Takashi, Takema, Yoshinori, Visscher, Marty O, Boissy, Raymond E

“…Skin color is one of the most distinct features in the human race. To assess the mechanisms of skin color variation, human skin substitutes (HSS) were…”
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Cooperation of endothelin-1 signaling with melanosomes plays a role in developing and/or maintaining human skin hyperpigmentation by Murase, Daiki, Hachiya, Akira, Kikuchi-Onoe, Mamiko, Fullenkamp, Rachel, Ohuchi, Atsushi, Kitahara, Takashi, Moriwaki, Shigeru, Hase, Tadashi, Takema, Yoshinori

“…Skin hyperpigmentation is characterized by increased melanin synthesis and deposition that can cause significant psychosocial and psychological distress…”
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Age-related changes in the epidermal architecture around facial pores by Sugiyama-Nakagiri, Yoriko, Sugata, Keiichi, Iwamura, Maeko, Ohuchi, Atsushi, Kitahara, Takashi

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inhibitory effect of a Platycodon root extract on ultraviolet B-induced pigmentation due to a decrease in Kit expression by Kasamatsu, Shinya, Hachiya, Akira, Shimotoyodome, Yoshie, Kameyama, Akiyo, Miyauchi, Yuki, Higuchi, Kazuhiko, Fujimori, Taketoshi, Ohuchi, Atsushi, Shibuya, Yusuke, Kitahara, Takashi

“…The signaling of stem cell factor (SCF) through its receptor Kit is known to play an important role in regulating cutaneous melanogenesis. In the course of…”
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Interaction between stem cell factor and endothelin-1: effects on melanogenesis in human skin xenografts by Sriwiriyanont, Penkanok, Ohuchi, Atsushi, Hachiya, Akira, Visscher, Marty O, Boissy, Raymond E

“…The two paracrine melanogenic cytokines, stem cell factor (SCF) and endothelin-1 (ET-1), have been demonstrated to play pivotal roles in skin pigmentation…”
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Lentiviral Vector-Mediated Gene Transfer to Human Hair Follicles by Sriwiriyanont, Penkanok, Hachiya, Akira, Pickens, William L., Moriwaki, Shigeru, Ohuchi, Atsushi, Kitahara, Takashi, Takema, Yoshinori, Kitzmiller, William J., Visscher, Marty O., Bello, Alexander, Tsuboi, Ryoji, Kobinger, Gary P.

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Inhibitory Mechanism of an Extract of Althaea officinalis L. on Endothelin-1-Induced Melanocyte Activation by Kobayashi, Akemi, Hachiya, Akira, Ohuchi, Atsushi, Kitahara, Takashi, Takema, Yoshinori

“…It is known that expression of endothelin-1 (ET-1) increases in the epidermis after UVB irradiation, and that this plays an important role during the induction…”
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The Inhibitory Effect of an Extract of Sanguisorba officinalis L. on Ultraviolet B-Induced Pigmentation via the Suppression of Endothelin-Converting Enzyme-1α by HACHIYA, Akira, KOBAYASHI, Akemi, OHUCHI, Atsushi, KITAHARA, Takashi, TAKEMA, Yoshinori

“…Endothelin-1 (ET-1) has been reported to be expressed in human epidermis at both the gene and protein levels. ET-1 plays a pivotal role in ultraviolet B…”
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Identification of a Novel TRPM8 Agonist from Nutmeg: A Promising Cooling Compound by Shirai, Tomohiro, Kumihashi, Kentaro, Sakasai, Mitsuyoshi, Kusuoku, Hiroshi, Shibuya, Yusuke, Ohuchi, Atsushi

“…The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary receptor for innocuous cold stimuli (<28 °C) in humans. TRPM8 agonists such as…”
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