Search Results - "OHTSUKA, EIKO"

Structural basis for recruitment of human flap endonuclease 1 to PCNA by Sakurai, Shigeru, Kitano, Ken, Yamaguchi, Hiroto, Hamada, Keisuke, Okada, Kengo, Fukuda, Kotaro, Uchida, Makiyo, Ohtsuka, Eiko, Morioka, Hiroshi, Hakoshima, Toshio

“…Flap endonuclease‐1 (FEN1) is a key enzyme for maintaining genomic stability and replication. Proliferating cell nuclear antigen (PCNA) binds FEN1 and…”
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Efficient synthesis of oligonucleotide conjugates on solid-support using an (aminoethoxycarbonyl)aminohexyl group for 5′-terminal modification by Kojima, Naoshi, Takebayashi, Toshie, Mikami, Akiko, Ohtsuka, Eiko, Komatsu, Yasuo

“…Solid-support conjugation at the 5′-terminal primary amine of oligonucleotides is a convenient and powerful method for introducing various functional groups…”
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Autonomic dysfunction in cases of spinal muscular atrophy type 1 with long survival by Hachiya, Yasuo, Arai, Hidee, Hayashi, Masaharu, Kumada, Satoko, Furushima, Wakana, Ohtsuka, Eiko, Ito, Yasushi, Uchiyama, Akira, Kurata, Kiyoko

“…In Japan, quite a few patients with spinal muscular atrophy type 1 (SMA type 1) survive with mechanical ventilation. Since a patient with SMA type 1 and…”
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Osteopontin small interfering RNA protects mice from fulminant hepatitis by Saito, Yoshinari, Kon, Shigeyuki, Fujiwara, Yukio, Nakayama, Yosuke, Kurotaki, Daisuke, Fukuda, Naoki, Kimura, Chiemi, Kanayama, Masashi, Ito, Koyu, Diao, Hongyan, Matsui, Yutaka, Komatsu, Yasuo, Ohtsuka, Eiko, Uede, Toshimitsu

“…Osteopontin (OPN) has been implicated in various helper T cell type 1 immunity-mediated diseases including rheumatoid arthritis (RA), multiple sclerosis (MS),…”
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Structure-Function Relationship of the Eukaryotic DNA Replication Factor, Proliferating Cell Nuclear Antigen (∗) by Fukuda, Kotaro, Morioka, Hiroshi, Imajou, Sayuri, Ikeda, Soichiro, Ohtsuka, Eiko, Tsurimoto, Toshiki

“…Proliferating cell nuclear antigen (PCNA) is essential for eukaryotic DNA replication and functions as a processivity factor of DNA polymerase δ (pol δ). Due…”
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Non-canonical hydrogen bonds in genetic information flow by OHTSUKA, Eiko

“…Non-Watson-Crick-type hydrogen bonds involving minor nucleosides such as inosine in anticodon loops of transfer RNA are found in nucleic acids. Inosine…”
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Enhanced reactivity of amino-modified oligonucleotides by insertion of aromatic residue by Kojima, Naoshi, Sugino, Maiko, Mikami, Akiko, Nonaka, Ken, Fujinawa, Yumi, Muto, Isamu, Matsubara, Kenichi, Ohtsuka, Eiko, Komatsu, Yasuo

“…We developed novel amino-modifying reagents, of which an amino group was connected with an aromatic residue by aliphatic linker. It was proved that the…”
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Human MMH (OGG1) Type 1a Protein Is a Major Enzyme for Repair of 8-Hydroxyguanine Lesions in Human Cells by Monden, Yoshiaki, Arai, Tsuyoshi, Asano, Midori, Ohtsuka, Eiko, Aburatani, Hiroyuki, Nishimura, Susumu

“…8-Hydroxyguanine (8-OH-G) is the site of a frequent mutagenic lesion of DNA, produced by oxidative damage. MutM ofE. coliand OGG1 ofSaccharomyces cervisiaeare…”
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Construction of new ribozymes requiring short regulator oligonucleotides as a cofactor by Komatsu, Yasuo, Yamashita, Shigeko, Kazama, Nobuhiro, Nobuoka, Kaoru, Ohtsuka, Eiko

“…A hairpin loop and an oligonucleotide bound to the loop form one-half of the pseudoknot structure. We have designed an allosteric hammerhead ribozyme, which is…”
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Pathological study of bronchospasms/tracheomalasia in patients with severe motor and intellectual disabilities by Ohtsuka, Eiko, Hayashi, Masaharu, Hamano, Kimiko, Kumada, Satoko, Uchiyama, Akira, Kurata, Kiyoko, Osawa, Makiko

“…This report concerns two autopsy cases of severe motor and intellectual disabilities (SMID) who died of bronchospasms or tracheomalasia. One case had no…”
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NMR studies of a DNA containing 8-hydroxydeoxyguanosine by ODA, Y, UESUGI, S, IKEHARA, M, NISHIMURA, S, KAWASE, Y, ISHIKAWA, H, INOUE, H, OHTSUKA, E

“…The effects of hydroxylation at the C8 of a deoxyguanosine residue in DNA were studied by NMR analysis of a self-complementary dodecanucleotide,…”
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Synthesis and hybridization studies on two complementary nona(2'-O-methyl)ribonucleotides by INOUE, H, HAYASE, Y, IMURA, A, IWAI, S, MIURA, K, OHTSUKA, E

“…2'-O-Methyl derivatives of the common ribonucleosides except for guanosine were synthesized via the 2'-O-methylation of appropriately-protected nucleosides…”
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How Does RNase H Recognize a DNA·RNA Hybrid? by NAKAMURA, H, ODA, Y, MIYASHIRO, H, IKEHARA, M, IWAI, S, INOUE, H, OHTSUKA, E, KANAYA, S, KIMURA, S, KATSUDA, C, KATAYANAGI, K, MORIKAWA, K

“…The mechanism of RNase H substrate recognition is proposed from a model of a chemically modified DNA-RNA hybrid Escherichia coli RNase H complex. Sitedirected…”
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Sequence-dependent hydrolysis of RNA using modified oligonucleotide splints and RNase H by Inoue, Hideo, Hayase, Yoji, Iwai, Shigenori, Ohtsuka, Eiko

“…We found that, in the presence of chimeric oligonucleotides containing complementary deoxyribo- and 2′- O-methylnucleosides, a nonaribonucleotide, [5′- 32…”
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Loop-Size Variation To Probe a Bent Structure of a Hairpin Ribozyme by Komatsu, Yasuo, Koizumi, Makoto, Nakamura, Haruki, Ohtsuka, Eiko

“…A two-stranded hairpin ribozyme, derived from the catalytic center of the negative strand of the tobacco ring spot virus satellite RNA, catalyzes the cleavage…”
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Oligo(2′- O-methyl)ribonucleotides Effective probes for duplex DNA by Shimizu, Miho, Konishi, Aritomo, Shimada, Yasuaki, Inoue, Hideo, Ohtsuka, Eiko

“…To find novel probes for duplex DNA, we prepared four types of triplexes containing a homopurine-homopyrimidine 15-mer duplex DNA, and examined their thermal…”
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Synthesis and characterization of a substrate for T4 endonuclease V containing a phosphorodithioate linkage at the thymine dimer site by MURATA, T, IWAI, S, OHTSUKA, E

“…A dodecadeoxyribonucleotide containing a cis-syn thymine dimer with a phosphorodithioate linkage was synthesized on a solid support using a dinucleotide…”
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Cleavage of specific sites of RNA by designed ribozymes by Koizumi, Makoto, Iwai, Shigenori, Ohtsuka, Eiko

“…Two ribozymes were designed for site-specific cleavage of RNA. A UA site in an undecaribonucleotide was cleaved by a ribozyme consisting of two partially…”
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Modification of Primary Structures of Hairpin Ribozymes for Probing Active Conformations by Komatsu, Yasuo, Kanzaki, Ikuyo, Koizumi, Makoto, Ohtsuka, Eiko

“…Hairpin ribozymes consist of two stem-loop domains, and these domains are assumed to interact with each other to produce the self-cleavage activity. We have…”
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Probing the Interaction between a High-Affinity Single-Chain Fv and a Pyrimidine (6-4) Pyrimidone Photodimer by Site-Directed Mutagenesis by Kobayashi, Hiroyuki, Morioka, Hiroshi, Tobisawa, Kunihiro, Torizawa, Takuya, Kato, Koichi, Shimada, Ichio, Nikaido, Osamu, Stewart, Jon D, Ohtsuka, Eiko

“…We have used site-directed mutagenesis to uncover the origin of the binding affinity differences exhibited by a series of monoclonal antibodies that recognize…”
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