Search Results - "OHTAKE, Toshiyuki"

Causes and countermeasure for blank absorbance increase in the ROS assay by Ohtake, Toshiyuki, Hirota, Morihiko

“…A reactive oxygen species (ROS) assay is an in chemico photoreactivity test listed in ICH S10 guideline and OECD Test Guideline No. 495. We currently utilize…”
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Metabolomics-driven approach to solving a CoA imbalance for improved 1-butanol production in Escherichia coli by Ohtake, Toshiyuki, Pontrelli, Sammy, Laviña, Walter A., Liao, James C., Putri, Sastia P., Fukusaki, Eiichiro

“…High titer 1-butanol production in Escherichia coli has previously been achieved by overexpression of a modified clostridial 1-butanol production pathway and…”
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A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia by Morino, Hiroyuki, Matsuda, Yukiko, Muguruma, Keiko, Miyamoto, Ryosuke, Ohsawa, Ryosuke, Ohtake, Toshiyuki, Otobe, Reiko, Watanabe, Masahiko, Maruyama, Hirofumi, Hashimoto, Kouichi, Kawakami, Hideshi

“…Spinocerebellar ataxia (SCA) is a genetically heterogeneous disease. To date, 36 dominantly inherited loci have been reported, and 31 causative genes have been…”
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Metabolomics-Driven Identification of the Rate-Limiting Steps in 1-Propanol Production by Ohtake, Toshiyuki, Kawase, Naoki, Pontrelli, Sammy, Nitta, Katsuaki, Laviña, Walter A, Shen, Claire R, Putri, Sastia P, Liao, James C, Fukusaki, Eiichiro

“…The concerted effort for bioproduction of higher alcohols and other commodity chemicals has yielded a consortium of metabolic engineering techniques to…”
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Reactive oxygen species (ROS) assay-based photosafety screening for complex ingredients: Modification of the ROS assay protocol by Ohtake, Hiroto, Tokuyoshi, Yasuharu, Iyama, Yosuke, Nukaga, Takumi, Nishida, Hayato, Ohtake, Toshiyuki, Hirota, Morihiko, Yamada, Kohei, Seto, Yoshiki, Sato, Hideyuki, Kouzuki, Hirokazu, Onoue, Satomi

“…A reactive oxygen species (ROS) assay has been widely used for photosafety assessment; however, the phototoxic potential of complex materials, including plant…”
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Recurrence of Acute Disseminated Encephalomyelitis after a 12-year Symptom-free Interval by OHTAKE, Toshiyuki, HIRAI, Shunsaku

“…We report a patient with recurrent acute meningoencephalitis who had three episodes of headache, fever and unconsciousness; the first episode was at age 6 and…”
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In chemico sequential testing strategy for assessing the photoallegic potential by Nishida, Hayato, Ohtake, Toshiyuki, Ashikaga, Takao, Hirota, Morihiko, Onoue, Satomi, Seto, Yoshiki, Tokura, Yoshiki, Kouzuki, Hirokazu

“…Several non-animal testing methods to assess photoallergic potential have been developed so far, while none of them have yet to be validated and regulatory…”
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A Patient with Myotonic Dystrophy Type 1 (DM1) Accompanied by Laryngeal and Renal Cell Carcinomas Had a Small CTG Triplet Repeat Expansion But No Somatic Instability in Normal Tissues by KINOSHITA, Masanobu, OSANAI, Ryuichi, KIKKAWA, Masaru, ADACHI, Akiko, OHTAKE, Toshiyuki, KOMORI, Tetsuo, HASHIMOTO, Kohzo, ITOYAMA, Shinnji, MITARAI, Tetsuya, HIROSE, Kazuhiko

“…We examined (CTG)n lengths in various tissues from a 70-year-old man with myotonic dystrophy type 1 (DM1) who had a small 60-70 (CTG)n expansion in his…”
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Applicability of an Integrated Testing Strategy consisting of in silico, in chemico and in vitro assays for evaluating the skin sensitization potencies of isocyanates by Ohtake, Toshiyuki, Maeda, Yosuke, Hayashi, Tae, Yamanaka, Hidenori, Nakai, Makoto, Takeyoshi, Masahiro

“…The skin sensitization potential of chemicals has been traditionally assessed using regulatory accepted in vivo methods, such as guinea pig maximization test…”
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Distinguishable effects of Presenilin-1 and APP717 mutations on amyloid plaque deposition by ISHII, Kazuhiro, LIPPA, Carol, POLLEN, Dan A, ST. GEORGE-HYSLOP, Peter H, II, Kunio, OHTAKE, Toshiyuki, KALARIA, Rajesh N, ROSSOR, Martin N, LANTOS, Peter L, CAIRNS, Nigel J, FARRER, Lindsay A, MORI, Hiroshi, TOMIYAMA, Takami, MIYATAKE, Fumiko, OZAWA, Kazuharu, TAMAOKA, Akira, HASEGAWA, Takashi, FRASER, Paul E, SHOJI, Shinichi, NEE, Linda E

“…Both APP and PS-1 are causal genes for early-onset familial Alzheimer's disease (AD) and their mutation effects on cerebral Abeta deposition in the senile…”
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Dementia of the frontal lobe type with clinicopathological features of corticobasal degeneration except for lack of glial cytoskeletal abnormalities by Yamaguchi, Shin‐ichi, Kojima, Hideaki, Ohtake, Toshiyuki, Oda, Masaya

“…A 60‐year‐old left‐handed lawyer presented with a pro‐gressive dementing, aphasic, and akinetic–rigid syndrome. He later developed stimulus‐sensitive…”
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Characteristic magnetic resonance imaging findings in Machado-Joseph disease by Murata, Y, Yamaguchi, S, Kawakami, H, Imon, Y, Maruyama, H, Sakai, T, Kazuta, T, Ohtake, T, Nishimura, M, Saida, T, Chiba, S, Oh-i, T, Nakamura, S

“…To clarify the characteristic magnetic resonance imaging (MRI) findings in patients with Machado-Joseph disease (MJD) diagnosed by genetic analysis. Using MRI,…”
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Acute limbic encephalitis: A new entity? by Mochizuki, Yoko, Mizutani, Toshio, Isozaki, Eiji, Ohtake, Toshiyuki, Takahashi, Yukitoshi

“…Clinical cases similar to herpes simplex virus (HSV) encephalitis have accumulated in Japan. Detailed examinations have failed to demonstrate HSV infection…”
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Nanonecklaces of Platinum and Gold with High Aspect Ratios Synthesized in Mesoporous Organosilica Templates by Wet Hydrogen Reduction by Fukuoka, Atsushi, Higuchi, Takanori, Ohtake, Toshiyuki, Oshio, Tadashi, Kimura, Jun-ichi, Sakamoto, Yuzuru, Shimomura, Noriyuki, Inagaki, Shinji, Ichikawa, Masaru

“…Nanowires of platinum and gold with high aspect ratios are synthesized in one-dimensional channels of ordered mesoporous organosilica HMM. Water-saturated…”
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Nickel-Catalyzed Cross-Coupling Reaction of Niobium(III)−Alkyne Complexes with Aryl Iodides by Obora, Yasushi, Kimura, Masahiro, Ohtake, Toshiyuki, Tokunaga, Makoto, Tsuji, Yasushi

“…Nickel−catalyzed cross-coupling reactions of Nb(III)−alkyne complexes with aryl iodides are reported, in which addition of lithium alkoxide is indispensable…”
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Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor by Heckers, S, Ohtake, T, Wiley, RG, Lappi, DA, Geula, C, Mesulam, MM

“…The immunotoxin 192 IgG-saporin, produced by coupling the ribosome-inactivating protein saporin to the monoclonal 192 IgG antibody against the low-affinity p75…”
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Molecular features of the CAG repeats and clinical manifestation of Machado-Joseph disease by Maruyama, H, Nakamura, S, Matsuyama, Z, Sakai, T, Doyu, M, Sobue, G, Seto, M, Tsujihata, M, Oh-i, T, Nishio, T

“…Machado--Joseph disease (MJD) is an autosomal dominant spinocerebellar degeneration mapped to chromosome 14q32.1. The CAG expansions of the MJD1 gene was…”
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A β1–40 but not A β1–42 levels in cortex correlate with apolipoprotein E ϵ4 allele dosage in sporadic Alzheimer's disease by Ishii, Kazuhiro, Tamaoka, Akira, Mizusawa, Hidehiro, Shoji, Shin-ichi, Ohtake, Toshiyuki, Fraser, Peter E, Takahashi, Hitoshi, Tsuji, Shoji, Gearing, Marla, Mizutani, Toshio, Yamada, Shigeo, Kato, Masanori, St.George-Hyslop, Peter H, Mirra, Suzanne S, Mori, Hiroshi

“…Apolipoprotein E (ApoE) ϵ4 allele is established to be a risk factor for the development of late-onset Alzheimer's disease (AD) which is associated with…”
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Ascending projections from the gigantocellular reticular and dorsal paragigantocellular nuclei of the medulla oblongata in the rat: an anterograde PHA-L tracing study by Ohtake, T

“…Ascending projections from the gigantocellular reticular (NGc) and dorsal paragigantocellular (DPG) nuclei of the medulla oblongata were examined in the rat by…”
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Multifocal polyradiculoneuropathy and carcinoma of the thymus by Ohtake, Toshiyuki, Nishimura, Masaki, Oda, Masaya

“…We studied a patient with polyradiculoneuropathy with anaplastic carcinoma of the thymus. Motor manifestations dominated. Postmortem examinations indicated…”
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