A Patient with Primary Biliary Cirrhosis Complicated with Slowly Progressive Insulin-dependent Diabetes Mellitus

We report a case of primary biliary cirrhosis (PBC) complicated by slowly progressive insulin-dependent diabetes mellitus (SPIDDM). A 67-year-old woman was diagnosed as having PBC based on clinical manifestations and a positive result of anti-mitochondrial antibody. Furthermore, SPIDDM was diagnosed...

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Published in:	Internal Medicine Vol. 42; no. 6; pp. 496 - 499
Main Authors:	NAKASONE, Hiroki, KINJO, Kazushi, YAMASHIRO, Masaaki, KAMIYAMA, Tsukasa, KAMIYAMA, Sakiko, MlYAZATO, Hitoshi, MATSUSHITA, Tatsuhiko, ARAKAWA, Yukihiro, OHSHIRO, Takeharu, TOMA, Shiyu, CHINEN, Kiyoharu, YAMASHIRO, Masato, MIYAGI, Masatake, MAKISHI, Tomoko, HOKAMA, Akira, SAKUGAWA, Hiroshi, KINJO, Fukunori, SAITO, Atsushi
Format:	Journal Article
Language:	English
Published:	Tokyo The Japanese Society of Internal Medicine 01-06-2003 Japanese Society of Internal Medicine
Subjects:	Aged Biological and medical sciences Blood Chemical Analysis Blood Glucose - analysis cirrhosis Combined Modality Therapy diabetes mellitus Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - therapy diagnosis Diet Disease Progression Female Gastroenterology. Liver. Pancreas. Abdomen Humans Insulin - therapeutic use Japan Liver Cirrhosis, Biliary - complications Liver Cirrhosis, Biliary - diagnosis Liver Cirrhosis, Biliary - therapy Liver Function Tests Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Other diseases. Semiology Prognosis Risk Assessment Severity of Illness Index Tomography, X-Ray Computed Treatment Outcome Japan Endocrinopathy Case study Human Diabetes mellitus Digestive diseases Hepatic disease Complication Biliary cirrhosis Diagnosis Biliary tract disease cirrhosis
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Summary:	We report a case of primary biliary cirrhosis (PBC) complicated by slowly progressive insulin-dependent diabetes mellitus (SPIDDM). A 67-year-old woman was diagnosed as having PBC based on clinical manifestations and a positive result of anti-mitochondrial antibody. Furthermore, SPIDDM was diagnosed by her clinical course and a positive result of anti-glutamic acid decarboxylase antibody. Both PBC and SPIDDM are considered to be autoimmune diseases. However, the coexistence of PBC and SPIDDM is extremely rare. Liver cirrhosis sometimes accompanies hyperglycemia. When the etiology of liver cirrhosis is an autoimmune disorder such as PBC, SPIDDM should be considered as a cause of hyperglycemia. (Internal Medicine 42: 496-499, 2003)
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0918-2918 1349-7235
DOI:	10.2169/internalmedicine.42.496