Search Results - "OHSHIMA, Etsuo"

Intranasal administration of polysulfide prevents neurodegeneration in spinal cord and rescues mice from delayed paraplegia after spinal cord ischemia by Kanemaru, Eiki, Miyazaki, Yusuke, Marutani, Eizo, Ezaka, Mariko, Goto, Shunsaku, Ohshima, Etsuo, Bloch, Donald B., Ichinose, Fumito

“…Delayed paraplegia is a devastating complication of thoracoabdominal aortic surgery. Hydrogen sulfide (H2S) was reported to be protective in a mouse model of…”
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Oral Administration of Glutathione Trisulfide Increases Reactive Sulfur Levels in Dorsal Root Ganglion and Ameliorates Paclitaxel-Induced Peripheral Neuropathy in Mice by Ezaka, Mariko, Marutani, Eizo, Miyazaki, Yusuke, Kanemaru, Eiki, Selig, Martin K., Boerboom, Sophie L., Ostrom, Katrina F., Stemmer-Rachamimov, Anat, Bloch, Donald B., Brenner, Gary J., Ohshima, Etsuo, Ichinose, Fumito

“…Peripheral neuropathy is a dose-limiting side effect of chemotherapy with paclitaxel. Paclitaxel-induced peripheral neuropathy (PIPN) is typically…”
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Differential Effects of PDE4 Inhibitors on Cortical Neurons and T-Lymphocytes by Hirose, Ryo, Manabe, Haruhiko, Yanagawa, Koji, Ohshima, Etsuo, Ichimura, Michio

“…Inhibitors of PDE4 (cAMP-specific phosphodiesterase) induce side effects, including nausea and emesis, that limit their therapeutic potential. We investigated…”
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Inhibitory effect of the 4-aminotetrahydroquinoline derivatives, selective chemoattractant receptor-homologous molecule expressed on T helper 2 cell antagonists, on eosinophil migration induced by prostaglandin D2 by Mimura, Hideki, Ikemura, Toshihide, Kotera, Osamu, Sawada, Masatsugu, Tashiro, Satoshi, Fuse, Eiichi, Ueno, Kimihisa, Manabe, Haruhiko, Ohshima, Etsuo, Karasawa, Akira, Miyaji, Hiromasa

“…Prostaglandin (PG) D2, a major cyclooxygenase metabolite generated from immunologically stimulated mast cells, is known to induce activation and chemotaxis in…”
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Solubilization and stabilization of lipoic acid trisulfide by creation of various β-cyclodextrin clathrates by Tomonaga, Shoichiro, Ishimaru, Hiroaki, Isobe, Takahiro, Ohshima, Etsuo, Kitagaki, Shinji

“…Lipoic acid trisulfide, a sulfane sulfur-containing trisulfide of α-lipoic acid, holds promise in pharmaceuticals, yet knowledge gaps persist regarding its…”
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One-Pot Synthesis of Glutathione Trisulfide from Oxidized Glutathione by Tomonaga, Shoichiro, Shimokawa, Ikumi, Nuno, Takahiro, Ishimaru, Hiroaki, Isobe, Takahiro, Ohshima, Etsuo, Kitagaki, Shinji

“…The excellent medicinal efficacy of glutathione trisulfide, an endogenous compound consisting of sulfane sulfur and two molecules of reduced glutathione, has…”
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Unique binding pocket for KW-4679 in the histamine H1 receptor by NONAKA, H, OTAKI, S, OHSHIMA, E, KONO, M, KASE, H, OHTA, K, FUKUI, H, ICHIMURA, M

“…The histamine H1 receptor has an aspartate (Asp) residue in transmembrane helix 3 (TM3), which is well-conserved among biogenic amine receptors. The Asp…”
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Endogenously released DOPA is a causal factor for glutamate release and resultant delayed neuronal cell death by transient ischemia in rat striata by Furukawa, Nobuya, Arai, Nobutaka, Goshima, Yoshio, Miyamae, Takeaki, Ohshima, Etsuo, Suzuki, Fumio, Fujita, Kiyohide, Misu, Yoshimi

“…Glutamate is implicated in neuronal cell death. Exogenously applied DOPA by itself releases neuronal glutamate and causes neuronal cell death in in vitro…”
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DOPA cyclohexyl ester, a competitive DOPA antagonist, protects glutamate release and resultant delayed neuron death by transient ischemia in hippocampus CA1 of conscious rats by Arai, Nobutaka, Furukawa, Nobuya, Miyamae, Takeaki, Goshima, Yoshio, Sasaki, Yukio, Ohshima, Etsuo, Suzuki, Fumio, Fujita, Kiyohide, Misu, Yoshimi

“…In rat striata, DOPA released is a causal factor for glutamate release and resultant delayed neuron death by four-vessel occlusion. Nanomolar DOPA cyclohexyl…”
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Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11-dihydrodibenz[b,e]oxepin derivatives by Ohshima, Etsuo, Otaki, Shizuo, Sato, Hideyuki, Kumazawa, Toshiaki, Obase, Hiroyuki, Ishii, Akio, Ishii, Hidee, Ohmori, Kenji, Hirayama, Noriaki

“…A new series of 11-substituted 6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid derivatives was synthesized and demonstrated to be orally active antiallergic…”
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Recent development of new drugs for the treatment of allergic diseases by Ohmori, Kenji, Adachi, Kei, Manabe, Haruhiko, Harada, Daisuke, Ohshima, Etsuo

“…Due to the prevalence of allergic diseases such as bronchial asthma, allergic rhinoconjunctivitis and dermallergosis, efforts at the discovery of novel and…”
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Pharmacological, Pharmacokinetic and Clinical Properties of Olopatadine Hydrochloride, a New Antiallergic Drug by Ohmori, Kenji, Hayashi, Ken-ichi, Kaise, Toshihiko, Ohshima, Etsuo, Kobayashi, Satoshi, Yamazaki, Takashi, Mukouyama, Akimichi

“…Olopatadine hydrochloride (olopatadine, 11-[(Z)-3-(dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid monohydrochloride) is a novel…”
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Internalization of CCR4 and inhibition of chemotaxis by K777, a potent and selective CCR4 antagonist by Sato, Takashi, Iwase, Miho, Miyama, Motoki, Komai, Masato, Ohshima, Etsuo, Asai, Akira, Yano, Hiroshi, Miki, Ichiro

“…CC chemokine receptor 4 (CCR4) is a G protein-coupled receptor that regulates the chemotaxis of Th2 lymphocytes, which are key players in allergic diseases…”
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Inhibitory effect of the new orally active CCR4 antagonist K327 on CCR4+CD4+ T cell migration into the lung of mice with ovalbumin-induced lung allergic inflammation by Sato, Takashi, Komai, Masato, Iwase, Miho, Kobayashi, Katsuya, Tahara, Harunobu, Ohshima, Etsuo, Arai, Hitoshi, Miki, Ichiro

“…CC chemokine receptor 4 (CCR4) is expressed on Th2 cells, found in inflamed tissues of allergic diseases, and is therefore suspected to be involved in the…”
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Correlation between emetic effect of phosphodiesterase 4 inhibitors and their occupation of the high-affinity rolipram binding site in Suncus murinus brain by Hirose, Ryo, Manabe, Haruhiko, Nonaka, Hiromi, Yanagawa, Koji, Akuta, Kaori, Sato, Soichiro, Ohshima, Etsuo, Ichimura, Michio

“…We employed an ex vivo [ 3H]rolipram binding experiment to elucidate the mechanism of emetic activity of phosphodiesterase 4 inhibitors. In Suncus murinus (an…”
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Probes for Narcotic Receptor Mediated Phenomena. 37. Synthesis and Opioid Binding Affinity of the Final Pair of Oxide-Bridged Phenylmorphans, the Ortho- and Para-b-Isomers and Their N-Phenethyl Analogues, and the Synthesis of the N-Phenethyl Analogues of the Ortho- and Para-d-Isomers by Kurimura, Muneaki, Liu, Hehua, Sulima, Agnieszka, Hashimoto, Akihiro, Przybyl, Anna K, Ohshima, Etsuo, Kodato, Shinichi, Deschamps, Jeffrey R, Dersch, Christina M, Rothman, Richard B, Lee, Yong Sok, Jacobson, Arthur E, Rice, Kenner C

“…In the isomeric series of 12 racemic topologically rigid N-methyl analogues of oxide-bridged phenylmorphans, all but two of the racemates, the ortho- and…”
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Synthesis of a Dibenz(b,e)oxepin-Bovine Serum Albumin Conjugate for Radioimmunoassay of KW-4679((Z)-11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenz(b,e)oxepin-2-acetic Acid Hydrochloride) by OHSHIMA, Etsuo, SATO, Hideyuki, OBASE, Hiroyuki, UCHIMURA, Tatsuo, KUWABARA, Takashi, KOBAYASHI, Satoshi

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l-DOPA Cyclohexyl Ester Is a Novel Potent and Relatively Stable Competitive Antagonist Against l-DOPA Among Several l-DOPA Ester Compounds by Furukawa, Nobuya, Goshima, Yoshio, Miyamae, Takeaki, Sugiyama, Yoshinobu, Shimizu, Minako, Ohshima, Etsuo, Suzuki, Fumio, Arai, Nobutaka, Fujita, Kiyohide, Misu, Yoshimi

“…We explored l-DOPA esters with chemically bulky structures to find a potent stable competitive antagonist against l-DOPA, compared to DOPA methyl ester (DOPA…”
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Probes for Narcotic Receptor Mediated Phenomena. 37. Synthesis and Opioid Binding Affinity of the Final Pair of Oxide-Bridged Phenylmorphans, the Ortho- and Para-b-Isomers and Their N-Phenethyl Analogues, and the Synthesis of the N-Phenethyl Analogues of the Ortho- and Para-d-Isomers by Kurimura, Muneaki, Liu, Hehua, Sulima, Agnieszka, Hashimoto, Akihiro, Przybyl, Anna K, Ohshima, Etsuo, Kodato, Shinichi, Deschamps, Jeffrey R, Dersch, Christina M, Rothman, Richard B, Lee, Yong Sok, Jacobson, Arthur E, Rice, Kenner C

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Probes for Narcotic Receptor Mediated Phenomena. 37.1 Synthesis and Opioid Binding Affinity of the Final Pair of Oxide-Bridged Phenylmorphans, the Ortho-and Para-b-Isomers and Their N-Phenethyl Analogues, and the Synthesis of the N-Phenethyl Analogues of the Ortho-and Para-d-Isomers by KURIMURA, Muneaki, HEHUA LIU, YONG SOK LEE, JACOBSON, Arthur E, RICE, Kenner C, SULIMA, Agnieszka, HASHIMOTO, Akihiro, PRZYBYL, Anna K, OHSHIMA, Etsuo, KODATO, Shinichi, DESCHAMPS, Jeffrey R, DERSCH, Christina M, ROTHMAN, Richard B

“…In the isomeric series of 12 racemic topologically rigid N -methyl analogues of oxide-bridged phenylmorphans, all but two of the racemates, the ortho - and…”
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