Search Results - "OHRT, Colin"

A randomized, double-blind, active-control trial to evaluate the efficacy and safety of a three day course of tafenoquine monotherapy for the treatment of Plasmodium vivax malaria by Fukuda, Mark M, Krudsood, Srivicha, Mohamed, Khadeeja, Green, Justin A, Warrasak, Sukhuma, Noedl, Harald, Euswas, Ataya, Ittiverakul, Mali, Buathong, Nillawan, Sriwichai, Sabaithip, Miller, R Scott, Ohrt, Colin

“…Tafenoquine is an investigational 8-aminoquinoline for the prevention of Plasmodium vivax relapse. Tafenoquine has a long half-life and the potential for more…”
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The metabolism of primaquine to its active metabolite is dependent on CYP 2D6 by Pybus, Brandon S, Marcsisin, Sean R, Jin, Xiannu, Deye, Gregory, Sousa, Jason C, Li, Qigui, Caridha, Diana, Zeng, Qiang, Reichard, Gregory A, Ockenhouse, Christian, Bennett, Jason, Walker, Larry A, Ohrt, Colin, Melendez, Victor

“…The efficacy of the 8-aminoquinoline (8AQ) drug primaquine (PQ) has been historically linked to CYP-mediated metabolism. Although to date no clear evidence…”
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CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine by Pybus, Brandon S, Sousa, Jason C, Jin, Xiannu, Ferguson, James A, Christian, Robert E, Barnhart, Rebecca, Vuong, Chau, Sciotti, Richard J, Reichard, Gregory A, Kozar, Michael P, Walker, Larry A, Ohrt, Colin, Melendez, Victor

“…The 8-aminoquinoline (8AQ) drug primaquine (PQ) is currently the only approved drug effective against the persistent liver stage of the hypnozoite forming…”
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Risk factor assessment for clinical malaria among forest-goers in a pre-elimination setting in Phu Yen Province, Vietnam by Canavati, Sara E, Kelly, Gerard C, Quintero, Cesia E, Vo, Thuan Huu, Tran, Long Khanh, Ohrt, Colin, Ngo, Thang Duc, Tran, Duong Thanh, Martin, Nicholas J

“…The transition from malaria control to elimination requires understanding and targeting interventions among high-risk populations. In Vietnam, forest-goers are…”
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Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity by Rochford, Rosemary, Ohrt, Colin, Baresel, Paul C., Campo, Brice, Sampath, Aruna, Magill, Alan J., Tekwani, Babu L., Walker, Larry A.

“…Individuals with glucose 6-phosphate dehydrogenase (G6PD) deficiency are at risk for the development of hemolytic anemia when given 8-aminoquinolines (8-AQs),…”
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The use of Fionet technology for external quality control of malaria rapid diagnostic tests and monitoring health workers' performance in rural military health facilities in Tanzania by Kalinga, Akili K, Ishengoma, Deus S, Kavishe, Reginald, Temu, Lucky, Mswanya, Christopher, Mwanziva, Charles, Mgina, Erick J, Chiduo, Sarah, Mahikwano, Lucas, Mgata, Saidi, Anova, Lalaine, Amoo, George, Wurapa, Eyako, Vesely, Brian, Kamau, Edwin, Hickman, Mark, Waters, Norman, Kreishman-Deitrick, Mara, Paris, Robert, Ohrt, Colin

“…Internal and external quality control (QC) of rapid diagnostic tests (RDTs) is important to increase reliability of RDTs currently used to diagnose malaria…”
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Randomized, Double-Blind Study of the Safety, Tolerability, and Efficacy of Tafenoquine versus Mefloquine for Malaria Prophylaxis in Nonimmune Subjects by NASVELD, Peter E, EDSTEIN, Michael D, PRESCOTT, William, REID, Mark, BRENNAN, Leonard, HARRIS, Ivor E, KITCHENER, Scott J, LEGGAT, Peter A, PICKFORD, Philip, KERR, Caron, OHRT, Colin

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Pharmacokinetics and pharmacodynamics of (+)-primaquine and (-)-primaquine enantiomers in rhesus macaques (Macaca mulatta) by Saunders, David, Vanachayangkul, Pattaraporn, Imerbsin, Rawiwan, Khemawoot, Phisit, Siripokasupkul, Raveewan, Tekwani, Babu L, Sampath, Aruna, Nanayakkara, N P Dhammika, Ohrt, Colin, Lanteri, Charlotte, Gettyacamin, Montip, Teja-Isavadharm, Paktiya, Walker, Larry

“…Primaquine (PQ) remains the sole available drug to prevent relapse of Plasmodium vivax malaria more than 60 years after licensure. While this drug was…”
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Use of a Rhesus Plasmodium cynomolgi Model to Screen for Anti-Hypnozoite Activity of Pharmaceutical Substances by DEYE, Gregory A, GETTAYACAMIN, Montip, OHRT, Colin, HANSUKJARIYA, Pranee, IM-ERBSIN, Rawiwan, SATTABONGKOT, Jetsumon, ROTHSTEIN, Yarrow, MACAREO, Louis, FRACISCO, Susan, BENNETT, Kent, MAGILL, Alan J

“…There remains a need for new drugs to prevent relapse of Plasmodium vivax or P. ovale infection. The relapsing primate malaria P. cynomolgi has been used for…”
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Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta) by Dow, Geoffrey S, Gettayacamin, Montip, Hansukjariya, Pranee, Imerbsin, Rawiwan, Komcharoen, Srawuth, Sattabongkot, Jetsumon, Kyle, Dennis, Milhous, Wilbur, Cozens, Simon, Kenworthy, David, Miller, Anne, Veazey, Jim, Ohrt, Colin

“…Tafenoquine is an 8-aminoquinoline being developed for radical cure (blood and liver stage elimination) of Plasmodium vivax. During monotherapy treatment, the…”
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Comparison of visual and automated Deki Reader interpretation of malaria rapid diagnostic tests in rural Tanzanian military health facilities by Kalinga, Akili K, Mwanziva, Charles, Chiduo, Sarah, Mswanya, Christopher, Ishengoma, Deus I, Francis, Filbert, Temu, Lucky, Mahikwano, Lucas, Mgata, Saidi, Amoo, George, Anova, Lalaine, Wurrapa, Eyako, Zwingerman, Nora, Ferro, Santiago, Bhat, Geeta, Fine, Ian, Vesely, Brian, Waters, Norman, Kreishman-Deitrick, Mara, Hickman, Mark, Paris, Robert, Kamau, Edwin, Ohrt, Colin, Kavishe, Reginald A

“…Although microscopy is a standard diagnostic tool for malaria and the gold standard, it is infrequently used because of unavailability of laboratory facilities…”
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Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers by DHAMMIKA NANAYAKKARA, N. P, TEKWANI, Babu L, FRONCZEK, Frank R, MELENDEZ, Victor, OHRT, Colin, REICHARD, Gregory A, MCCHESNEY, James D, ROCHFORD, Rosemary, WALKER, Larry A, BANDARA HERATH, H. M. T, SAHU, Rajnish, GETTAYACAMIN, Montip, TUNGTAENG, Anchalee, VAN GESSEL, Yvonne, BARESEL, Paul, WICKHAM, Kristina S, BARTLETT, Marilyn S

“…Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only…”
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Assessment of Azithromycin in Combination with Other Antimalarial Drugs against Plasmodium falciparum In Vitro by OHRT, Colin, WILLINGMYRE, George D, LEE, Patricia, KNIRSCH, Charles, MILHOUS, Wilbur

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In Vitro Antimalarial Activity of Azithromycin, Artesunate, and Quinine in Combination and Correlation with Clinical Outcome by NOEDL, Harald, KRUDSOOD, Srivicha, SRIWICHAI, Sabaithip, OHRT, Colin, KNIRSCH, Charles, LEOWATTANA, Wattana, TANGPUKDEE, Noppadon, THANACHARTWET, Wipa, LOOAREESUWAN, Sornchai, MILLER, Robert Scott, FUKUDA, Mark, JONGSAKUL, Krisada, YINGYUEN, Kritsanai

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Absolute Bioavailability of cis-Mirincamycin and trans-Mirincamycin in Healthy Rhesus Monkeys and Ex Vivo Antimalarial Activity against Plasmodium falciparum by KHEMAWOOT, Phisit, SAUNDERS, David, RASAMEESORAJ, Maneerat, MELENDEZ, Victor, IMERBSIN, Rawiwan, OHRT, Colin, FRACISCO, Susan, TEJA-ISAVADHARM, Paktiya

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Azithromycin Combination Therapy with Artesunate or Quinine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Adults: A Randomized, Phase 2 Clinical Trial in Thailand by Noedl, Harald, Krudsood, Srivicha, Chalermratana, Kobsiri, Silachamroon, Udomsak, Leowattana, Wattana, Tangpukdee, Noppadon, Looareesuwan, Sornchai, Miller, Robert Scott, Fukuda, Mark, Jongsakul, Krisada, Sriwichai, Sabaithip, Rowan, Jacqueline, Bhattacharyya, Helen, Ohrt, Colin, Knirsch, Charles

“…Background. Because antimalarial drug resistance is spreading, there is an urgent need for new combination treatments for malaria, which kills >1 million…”
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A New Primaquine Analogue, Tafenoquine (WR 238605), for Prophylaxis against Plasmodium falciparum Malaria by Shanks, G. Dennis, Oloo, Aggrey J., Aleman, Gladys M., Ohrt, Colin, Klotz, Francis W., Braitman, David, Horton, John, Brueckner, Ralf

“…We tested tafenoquine (WR 238605), a new long-acting 8-aminoquinoline, for its ability to prevent malaria in an area that is holoendemic for Plasmodium…”
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Establishing a malaria diagnostics centre of excellence in Kisumu, Kenya by Ohrt, Colin, Obare, Peter, Nanakorn, Ampon, Adhiambo, Christine, Awuondo, Ken, O'Meara, Wendy Prudhomme, Remich, Shon, Martin, Kurt, Cook, Earnest, Chretien, Jean-Paul, Lucas, Carmen, Osoga, Joseph, McEvoy, Peter, Owaga, Martin Lucas, Odera, James Sande, Ogutu, Bernhards

“…Malaria microscopy, while the gold standard for malaria diagnosis, has limitations. Efficacy estimates in drug and vaccine malaria trials are very sensitive to…”
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Changes in the total leukocyte and platelet counts in Papuan and non Papuan adults from northeast Papua infected with acute Plasmodium vivax or uncomplicated Plasmodium falciparum malaria by Taylor, Walter R J, Widjaja, Hendra, Basri, Hasan, Ohrt, Colin, Taufik, Taufik, Tjitra, Emiliana, Baso, Samuel, Fryauff, David, Hoffman, Stephen L, Richie, Thomas L

“…There are limited data on the evolution of the leukocyte and platelet counts in malaria patients. In a clinical trial of chloroquine vs. chloroquine plus…”
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Pilot assessment of the sensitivity of the malaria thin film by Ohrt, Colin, O'Meara, Wendy Prudhomme, Remich, Shon, McEvoy, Peter, Ogutu, Bernhards, Mtalib, Ramadan, Odera, James Sande

“…Malaria microscopy remains the reference standard for malaria diagnosis in clinical trials (drug and vaccine), new diagnostic evaluation, as well as in…”
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