Search Results - "OHKURA, Naoki"

Paclitaxel and Vinblastine Increase Plasminogen Activator Inhibitor-1 Production in Human Breast Cancer MCF-7 Cells but Not MDA-MB-231 Cells by Morimoto-Kamata, Riyo, Ohkura, Naoki

“…Cancer chemotherapy increases the risk of thrombosis; however, the mechanisms underlying this thrombosis are not completely understood. Plasminogen activator…”
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Potential applications of Chinese herbal medicines with hemostatic properties by Ohkura, Naoki

“…Various herbal medicines with hemostatic properties have been applied for centuries to accelerate hemostasis and control bleeding. However, the mechanisms of…”
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Cathepsin G-Induced Cell Aggregation of Breast Cancer MCF-7 Decreases Doxorubicin Sensitivity in a Hypoxia-Inducible Factor-Independent Mechanism by Morimoto-Kamata, Riyo, Matsuki, Shun, Ohkura, Naoki, Yui, Satoru

“…Solid tumors habitually harbor regions with insufficient oxygen away from vasculature. Hypoxia is an important factor that confers malignant phenotypes like…”
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Nobiletin and 3′-Demethyl Nobiletin Activate Brown Adipocytes upon β-Adrenergic Stimulation by Kihara-Negishi, Fumiko, Ohkura, Naoki, Takahashi, Yuka, Fujita, Toshiyuki, Nakamura, Yasuhiro, Maruyama, Keiji, Oshitari, Tetsuta, Yamaguchi, Shinji

“…Brown adipose tissue (BAT) specifically regulates energy expenditure via heat production. Nobiletin (NOB), a natural polymethoxylated flavone present in citrus…”
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Extracellular Vesicles Derived from 3T3-L1 Adipocytes Enhance Procoagulant Activity by Nakatani, Eriko, Naito, Yasuo, Ishibashi, Kenichi, Ohkura, Naoki, Atsumi, Gen-ichi

“…Obesity is associated with the risk of venous thromboembolism. Thrombi are constantly formed via the coagulation cascade and degraded by the fibrinolytic…”
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A ketogenic diet containing medium-chain triglycerides reduces REM sleep duration without significant influence on mouse circadian phenotypes by Zhuang, Haotong, Fujikura, Yuri, Ohkura, Naoki, Higo-Yamamoto, Sayaka, Mishima, Taiga, Oishi, Katsutaka

“…[Display omitted] •MCT-KD induced ketogenesis without carbohydrate starvation in mice.•MCT-KD minimally affected clock gene expression and core body…”
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Up-regulation of the expression of leucine-rich α2-glycoprotein in hepatocytes by the mediators of acute-phase response by Shirai, Ryoichi, Hirano, Fumiyasu, Ohkura, Naoki, Ikeda, Kiyoshi, Inoue, Seiji

“…Leucine-rich α 2 -glycoprotein (LRG) is a plasma protein in which leucine-rich repeats (LRRs) were first discovered. Although the physiological function of LRG…”
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Associating Liver Partial Partition and Transileocecal Portal Vein Embolization for Staged Hepatectomy by Sakamoto, Yoshihiro, Inagaki, Fuyuki, Omichi, Kiyohiko, Ohkura, Naoki, Hasegawa, Kiyoshi, Kokudo, Norihiro

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Age-dependent sex difference of non-alcoholic fatty liver disease in TSOD and db/db mice by Dungubat, Erdenetsogt, Kusano, Hiroyuki, Mori, Ichiro, Tawara, Hirosuke, Sutoh, Mitsuko, Ohkura, Naoki, Takanashi, Masakatsu, Kuroda, Masahiko, Harada, Naoki, Udo, Emiko, Souda, Masakazu, Furusato, Bungo, Fukusato, Toshio, Takahashi, Yoshihisa

“…According to previous clinical studies, the prevalence of non-alcoholic fatty liver disease (NAFLD) is higher in men than women only during the reproductive…”
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The Association Between Deep Vein Thrombosis, Pulmonary Embolism, and Janus Kinase Inhibitors: Reporting Status and Signal Detection in the Japanese Adverse Drug Event Report Database by Maeshima, Tae, Aisu, Sayaka, Ohkura, Naoki, Watanabe, Machiko, Itagaki, Fumio

“…Background Although Janus kinase (JAK) inhibitors have expanding indications, deep vein thrombosis (DVT) and pulmonary embolism (PE) are serious adverse events…”
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Chemotactic activity of products of Elizabethkingia anophelis derived from Aedes albopictus against RAW264 murine macrophage cell line by Yui, Satoru, Fujii, Norihiko, Terauchi, Jo, Tanabe, Nana, Kanno, Marie, Umehara, Kouta, Iijima, Ryosuke, Kamata, Riyo, Ohkura, Naoki, Kishimoto, Seishi, Sasaki, Toshinori

“…Dengue viruses enter dermal macrophages which are derived from other tissues after mosquito bites. We examined chemotactic factors derived from the dengue…”
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Hypofibrinolytic phenotype in Tsumura Suzuki Obese Diabetes (TSOD) mice unrelated to hyperglycemia by Ohkura, Naoki, Morimoto-Kamata, Riyo, Kamikubo, Yuichi, Takahashi, Yoshihisa, Oishi, Katsutaka

“…Obesity and diabetes mellitus are associated with increased risk of arterial thrombosis and venous thromboembolism. Tsumura Suzuki Obese Diabetes (TSOD) mice…”
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Circadian fluctuations in circulating plasminogen activator inhibitor-1 are independent of feeding cycles in mice by Oishi, Katsutaka, Ohkura, Naoki, Yasumoto, Yuki, Yamamoto, Saori

“…To evaluate the involvement of the day-night feeding cycle in the circadian regulation of circulating plasminogen activator inhibitor-1 (PAI-1) concentrations,…”
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Acidic Sialidase Activity Is Aberrant in Obese and Diabetic Mice by Natori, Yujin, Ohkura, Naoki, Nasui, Miwako, Atsumi, Gen-ichi, Kihara-Negishi, Fumiko

“…Mammalian sialidases (NEU1, NEU2, NEU3 and NEU4) that remove sialic acids from glycoconjugates have been implicated in diverse cellular functions. Human…”
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Chronic circadian clock disruption induces expression of the cardiovascular risk factor plasminogen activator inhibitor-1 in mice by Oishi, Katsutaka, Ohkura, Naoki

“…Links between shift work and increases in metabolic risk factors for cardiovascular diseases have been documented in detail, although the underlying causes…”
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Activation of PPARγ at an Early Stage of Differentiation Enhances Adipocyte Differentiation of MEFs Derived from Type II Diabetic TSOD Mice and Alters Lipid Droplet Morphology by Ishibashi, Kenichi, Takeda, Yoshihiro, Nakatani, Eriko, Sugawara, Kana, Imai, Ryo, Sekiguchi, Mayu, Takahama, Risa, Ohkura, Naoki, Atsumi, Gen-ichi

“…Type 2 diabetic Tsumura, Suzuki, obese, diabetes (TSOD) mice gradually gain weight as compared to corresponding Tsumura, Suzuki, non-obesity (TSNO) control…”
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Ashitaba (Angelica Keiskei) Exudate Prevents Increases in Plasminogen Activator Inhibitor-1 Induced by Obesity in Tsumura Suzuki Obese Diabetic Mice by Ohta, Mitsuhiro, Fujinami, Aya, Oishi, Katsutaka, Kobayashi, Norihiro, Ohnishi, Katsunori, Ohkura, Naoki

“…Angelica keiskei koidzumi (ashitaba) is consumed as a traditional folk medicine and health food in Japan. Ashitaba extract contains abundant flavonoids…”
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Ketogenic Diet Disrupts the Circadian Clock and Increases Hypofibrinolytic Risk by Inducing Expression of Plasminogen Activator Inhibitor-1 by Oishi, Katsutaka, Uchida, Daisuke, Ohkura, Naoki, Doi, Ryosuke, Ishida, Norio, Kadota, Koji, Horie, Shuichi

“…OBJECTIVES—Metabolic disorders such as diabetes and obesity are considered risk factors for cardiovascular diseases by increasing levels of blood plasminogen…”
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Circadian mRNA expression of coagulation and fibrinolytic factors is organ-dependently disrupted in aged mice by Oishi, Katsutaka, Koyanagi, Satoru, Ohkura, Naoki

“…To evaluate the effects of aging on the circadian gene expression of coagulation and fibrinolytic factors in the mouse tissues, we examined temporal mRNA…”
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Cinnamic acid shortens the period of the circadian clock in mice by Oishi, Katsutaka, Yamamoto, Saori, Oike, Hideaki, Ohkura, Naoki, Taniguchi, Masahiko

“…Cinnamic acid (CA) derivatives have recently received focus due to their anticancer, antioxidant, and antidiabetic properties. The present study aimed to…”
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