Search Results - "OHKAWA, Kiyoshi"

Proteasome inhibitor-resistant cells cause EMT-induction via suppression of E-cadherin by miR-200 and ZEB1 by ASAKURA, TADASHI, YAMAGUCHI, NORIKO, OHKAWA, KIYOSHI, YOSHIDA, KIYOTSUGU

“…Downregulation of E-cadherin (gene: CDH1) plays an important role in epithelial-mesenchymal transition (EMT), which is critical for normal development and…”
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Bio-artificial bone formation model with a radial-flow bioreactor for implant therapy—comparison between two cell culture carriers: porous hydroxyapatite and β-tricalcium phosphate beads by Nomoto, Hideki, Maehashi, Haruka, Shirai, Misako, Nakamura, Mariko, Masaki, Takahiro, Mezaki, Yoshihiro, Park, Jonghyuk, Aizawa, Mamoru, Ohkawa, Kiyoshi, Yoshida, Kiyotsugu, Matsuura, Tomokazu

“…Bone grafting is necessary before dental implant treatment in patients with jaw bone defects. Currently, autologous bone grafting is a major burden on the…”
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An efficient system for secretory production of fibrinogen using a hepatocellular carcinoma cell line by Matsumoto, Michinori, Matsuura, Tomokazu, Aoki, Katsuhiko, Maehashi, Haruka, Iwamoto, Takeo, Ohkawa, Kiyoshi, Yoshida, Kiyotsugu, Yanaga, Katsuhiko, Takada, Koji

“…Aim Despite an increasing demand, blood products are not always safe because most are derived from blood donations. One possible solution is the development…”
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Survivin expression in early hepatocellular carcinoma and post-treatment with anti-cancer drug under hypoxic culture condition by Mamori, Satoshi, Asakura, Tadashi, Ohkawa, Kiyoshi, Tajiri, Hisao

“…To investigate the expression of survivin during the early stages of hepatocellular carcinoma (HCC). Immunohistochemical expression of survivin in liver tumor…”
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CD147 and matrix metalloproteinase‐2 protein expression as significant prognostic factors in esophageal squamous cell carcinoma by Ishibashi, Yoshio, Matsumoto, Tomoe, Niwa, Mikio, Suzuki, Yutaka, Omura, Nobuo, Hanyu, Nobuyoshi, Nakada, Koji, Yanaga, Katsuhiko, Yamada, Kyosuke, Ohkawa, Kiyoshi, Kawakami, Makio, Urashima, Mitsuyoshi

“…BACKGROUND The authors investigated whether the presence of matrix metalloproteinase‐2 (MMP‐2) and its inducer, CD147, in cancerous esophageal lesions and…”
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ENU-induced missense mutation in the C-propeptide coding region of Col2a1 creates a mouse model of platyspondylic lethal skeletal dysplasia, Torrance type by Furuichi, Tatsuya, Masuya, Hiroshi, Murakami, Tomohiko, Nishida, Keiichiro, Nishimura, Gen, Suzuki, Tomohiro, Imaizumi, Kazunori, Kudo, Takashi, Ohkawa, Kiyoshi, Wakana, Shigeharu, Ikegawa, Shiro

“…The COL2A1 gene encodes the α1(II) chain of the homotrimeric type II collagen, the most abundant protein in cartilage. In humans, COL2A1 mutations create many…”
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FGF-2 signaling induces downregulation of TAZ protein in osteoblastic MC3T3-E1 cells by Eda, Homare, Aoki, Katsuhiko, Marumo, Keishi, Fujii, Katsuyuki, Ohkawa, Kiyoshi

“…Transcriptional coactivator with PDZ-binding motif (TAZ) protein is a coactivator of Runx2 and corepressor of PPARγ. It also induces differentiation of…”
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Transplantation of Liver Organoids in the Omentum and Kidney by Saito, Ryota, Ishii, Yuji, Ito, Ryusuke, Nagatsuma, Keisuke, Tanaka, Ken, Saito, Masaya, Maehashi, Haruka, Nomoto, Hideki, Ohkawa, Kiyoshi, Mano, Hiroshi, Aizawa, Mamoru, Hano, Hiroshi, Yanaga, Katsuhiko, Matsuura, Tomokazu

“…Liver organoids were reconstructed by mouse‐immortalized hepatocytes and nonparenchymal cells (sinusoidal endothelial cells and hepatic stellate cells) in a…”
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The proteasome inhibitor bortezomib inhibits FGF-2-induced reduction of TAZ levels in osteoblast-like cells by Eda, Homare, Aoki, Katsuhiko, Kato, Soki, Okawa, Yutaka, Takada, Koji, Tanaka, Takaaki, Marumo, Keishi, Ohkawa, Kiyoshi

“…Objectives: Bortezomib (PS‐341; Velcade™), a proteasome inhibitor, is used as a therapeutic agent for multiple myeloma. Bortezomib has been shown to strongly…”
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Chemotherapeutic agents that induce mitochondrial apoptosis by Asakura, Tadashi, Ohkawa, Kiyoshi

“…In cancer chemotherapy, it is necessary to design an agent that suppresses or inhibits the targets that influence cell growth and apoptosis. We focus on the…”
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Pilot study of CD147 protein expression in epithelial ovarian cancer using monoclonal antibody 12C3 by Ueda, Kazu, Yamada, Kyosuke, Kiyokawa, Takako, Iida, Yasushi, Nagata, Chie, Hamada, Tomomi, Saito, Misato, Aoki, Katsuhiko, Yanaihara, Nozomu, Takakura, Satoshi, Okamoto, Aikou, Ochiai, Kazunori, Ohkawa, Kiyoshi, Tanaka, Tadao

“…Aim:  CD147 is a membrane glycoprotein that is expressed in various cancer cells and is involved in tumor invasion and metastasis by inducing stromal…”
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Conformational change in the active center region of GST P1-1, due to binding of a synthetic conjugate of DXR with GSH, enhanced JNK-mediated apoptosis by Asakura, Tadashi, Sasagawa, Atsuko, Takeuchi, Hitoshi, Shibata, Shun-ichi, Marushima, Hideki, Mamori, Satoshi, Ohkawa, Kiyoshi

“…Treatment of cells with a synthetic conjugate of DXR with GSH via glutaraldehyde (GSH-DXR) caused cytochrome c to be released from the mitochondria to the…”
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Useful detection of CD147 (EMMPRIN) for pathological diagnosis of early hepatocellular carcinoma in needle biopsy samples by Mamori, Satoshi, Nagatsuma, Keisuke, Matsuura, Tomokazu, Ohkawa, Kiyoshi, Hano, Hiroshi, Fukunaga, Masaharu, Matsushima, Masato, Masui, Yoshifumi, Fushiya, Nao, Onoda, Hiroshi, Searashi, Yasuyuki, Takagi, Ichiro, Tagiri, Hisao

“…To make clear whether CD147 (EMMPRIN) expression in pathological tumor samples with a fine-needle aspiration biopsy is useful for pathological diagnosis of…”
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Purification and identification of SDS-solubilized ubiquitin-conjugates accumulated in brains of Niemann-Pick C disease mouse by Shimada, Yohta, Fukuda, Takahiro, Ohashi, Toya, Sunahara, Koichi, Ohkawa, Kiyoshi, Takada, Koji

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3B-11 Sequencing of the attractin gene in the black coat color mutant of Phodopus campbelli by WADA Adumi, OHKAWA Kiyoshi, TSUDZUKI Masaoki

“…Phodopus hamsters, which inhabit the northeast and central areas of Eurasian Continent, are thought to be a good candidate for a laboratory animal, and we have…”
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Extracorporeal Bioartificial Liver Using the Radial-flow Bioreactor in Treatment of Fatal Experimental Hepatic Encephalopathy by Kanai, Hideki, Marushima, Hideki, Kimura, Naofumi, Iwaki, Takamasa, Saito, Masaya, Maehashi, Haruka, Shimizu, Keiko, Muto, Makiko, Masaki, Takahiro, Ohkawa, Kiyoshi, Yokoyama, Keitaro, Nakayama, Masaaki, Harada, Tohru, Hano, Hiroshi, Hataba, Yoshiaki, Fukuda, Takahiro, Nakamura, Masahiko, Totsuka, Naoto, Ishikawa, Shutaro, Unemura, Yasuki, Ishii, Yuji, Yanaga, Katsuhiko, Matsuura, Tomokazu

“…:  An extracorporeal bioartificial liver (BAL) that could prevent death from hepatic encephalopathy in acute hepatic insufficiency was aimed to develop. A…”
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General sessions3C-06 Sequencing of the tyrosinase-related protein 1 gene in the black-eyed yellow coated mutant Phodopus campbelli by WADA Adumi, OHKAWA Kiyoshi, TSUDZUKI Masaoki

“…The Phodopus campbelli is a small hamster that inhabits the northeast and central areas of the Eurasian Continent, and domesticated as a fancy animal. In…”
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Purification and identification of monoubiquitin‐phosphoglycerate mutase B complex from human colorectal cancer tissues by Usuba, Teruyuki, Ishibashi, Yoshio, Okawa, Yutaka, Hirakawa, Tae, Takada, Koji, Ohkawa, Kiyoshi

“…Ubiquitin‐conjugated proteins in human colorectal cancer tissues were analyzed by the immunoprecipitation with the antibody FK2 against conjugated ubiquitin…”
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Chemotherapeutic Effect of CD147 Antibody-labeled Micelles Encapsulating Doxorubicin Conjugate Targeting CD147-Expressing Carcinoma Cells by Asakura, Tadashi, Yokoyama, Masayuki, Shiraishi, Koichi, Aoki, Katsuhiko, Ohkawa, Kiyoshi

“…CD147 (basigin/emmprin) is expressed on the surface of carcinoma cells. For studying the efficacy of CD147-targeting medicine on CD147-expressing cells, we…”
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Antibody to human α-fetoprotein inhibits cell growth of human hepatocellular carcinoma cells by resuscitating the PTEN molecule: in vitro experiments by Ohkawa, Kiyoshi, Asakura, Tadashi, Tsukada, Yutaka, Matsuura, Tomokazu

“…It has been proposed that α-fetoprotein (AFP) is a new member of the intracellular signaling molecule family of the phosphoinositide 3-kinase (PI3K)/AKT…”
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